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Table 3 Influencing parameters for outcome, incremental cost and incremental cost effectiveness ratio (ICER) in the models

From: Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools

Parameters Outcomes Incremental costs ICER
  DALY averted QALY gained      Per DALY averted Per QALY gained
  TriVac (default) TriVac (± 20%) ADIP (± 20%) SUPR (± 20%) TriVac (default) TriVac (± 20%) ADIP (± 20%) SUPR (± 20%) TriVac (default) TriVac (± 20%) ADIP (± 20%) SUPR (± 20%)
Population:             
Total number of births per year + + ++ 0 + + +++ ++++ + +   ++
Life expectancy at birth 0 + ++ ++ 0 0 + 0 0 +   ++
Under 5 years mortality per 1,000 live births 0 ++ - - 0 + - - 0 ++   -
Burden of disease:             
Incidence of pneumococcal pneumonia (per 100,000 per year) ++ ++ ++ - + + ++++ - ++ ++   -
Incidence of meningitis (per 100,000 per year) ++ + + - + + + - ++ +   -
Incidence of invasive NPNM (per 100,000 per year) ++ ++ + - + + + - ++ ++   -
Prevalence of bacteremia sp < 10 years (cases per year) - - - ++ - - - + - -   ++
Case fatality rate of pneumococcal pneumonia 0 ++ ++ + 0 0 + 0 0 ++   +
Case fatality rate of invasive NPNM 0 ++ + ++ 0 0 + 0 0 ++   ++
Vaccine information:             
Vaccine efficacy of pneumococcal pneumonia ++ ++ ++ ++ + + + + ++ ++   ++
Vaccine efficacy of pneumococcal invasive NPNM + ++ + ++ + + + + + ++   ++
Vaccine efficacy adjusted NTHi - - - ++ - - - + - -   ++
Vaccine coverage + + ++ ++ + ++ ++++ +++ + +   ++
Serotype coverage of pneumococcal pneumonia +++ ++ ++ + + + ++++ + +++ ++   ++
Number of doses - - - + - - - +++ - -   +++
Dose cost 0 0 0 0 0 +++ ++ +++ 0 ++   ++
Other parameters:             
Coverage 20 years after vaccine introduced (dose 1) + ++ - - + ++ - - + ++   -
Coverage 20 years after vaccine introduced (dose 3) + ++ - - + ++ - - + ++   -
GP visits < 10 years (AOM) - - - ++ - - - + - -   ++
Proportion sp of AOM        -   - -   ++
Probability of death - - - ++ - - - 0 - -   ++
  1. 0 = no change; - = not available; + = percentage change < 5%; ++ = percentage change 5% to 30%; +++ = percentage change 30% to 50%; ++++ = percentage change > 50%.
  2. AOM = acute otitis media; NPNM = non-pneumonia non-meningitis; NTHi = non-typeable Haemophilus influenza.
  3. ADIP = Pneumo ADIP; SUPR = Supremes