Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools

Table 3 Influencing parameters for outcome, incremental cost and incremental cost effectiveness ratio (ICER) in the models

Parameters	Outcomes				Incremental costs				ICER
	DALY averted			QALY gained					Per DALY averted			Per QALY gained
	TriVac (default)	TriVac (± 20%)	ADIP (± 20%)	SUPR (± 20%)	TriVac (default)	TriVac (± 20%)	ADIP (± 20%)	SUPR (± 20%)	TriVac (default)	TriVac (± 20%)	ADIP (± 20%)	SUPR (± 20%)
Population:
Total number of births per year	+	+	++	0	+	+	+++	++++	+	+		++
Life expectancy at birth	0	+	++	++	0	0	+	0	0	+		++
Under 5 years mortality per 1,000 live births	0	++	-	-	0	+	-	-	0	++		-
Burden of disease:
Incidence of pneumococcal pneumonia (per 100,000 per year)	++	++	++	-	+	+	++++	-	++	++		-
Incidence of meningitis (per 100,000 per year)	++	+	+	-	+	+	+	-	++	+		-
Incidence of invasive NPNM (per 100,000 per year)	++	++	+	-	+	+	+	-	++	++		-
Prevalence of bacteremia sp < 10 years (cases per year)	-	-	-	++	-	-	-	+	-	-		++
Case fatality rate of pneumococcal pneumonia	0	++	++	+	0	0	+	0	0	++		+
Case fatality rate of invasive NPNM	0	++	+	++	0	0	+	0	0	++		++
Vaccine information:
Vaccine efficacy of pneumococcal pneumonia	++	++	++	++	+	+	+	+	++	++		++
Vaccine efficacy of pneumococcal invasive NPNM	+	++	+	++	+	+	+	+	+	++		++
Vaccine efficacy adjusted NTHi	-	-	-	++	-	-	-	+	-	-		++
Vaccine coverage	+	+	++	++	+	++	++++	+++	+	+		++
Serotype coverage of pneumococcal pneumonia	+++	++	++	+	+	+	++++	+	+++	++		++
Number of doses	-	-	-	+	-	-	-	+++	-	-		+++
Dose cost	0	0	0	0	0	+++	++	+++	0	++		++
Other parameters:
Coverage 20 years after vaccine introduced (dose 1)	+	++	-	-	+	++	-	-	+	++		-
Coverage 20 years after vaccine introduced (dose 3)	+	++	-	-	+	++	-	-	+	++		-
GP visits < 10 years (AOM)	-	-	-	++	-	-	-	+	-	-		++
Proportion sp of AOM							-		-	-		++
Probability of death	-	-	-	++	-	-	-	0	-	-		++

0 = no change; - = not available; + = percentage change < 5%; ++ = percentage change 5% to 30%; +++ = percentage change 30% to 50%; ++++ = percentage change > 50%.
AOM = acute otitis media; NPNM = non-pneumonia non-meningitis; NTHi = non-typeable Haemophilus influenza.
ADIP = Pneumo ADIP; SUPR = Supremes

ISSN: 1741-7015