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Table 4 Outputs of all three models using standardized set of input parameters for hypothetical countries in the subA-Saharan African (SSA) region, Southeast Asian (SEA) region and Latin America and the Caribbean (LAC) region

From: Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools

  Hypothetical country, SSA region Hypothetical country, SEA region Hypothetical country, LAC region
Results ADIP Pan-American Health Organization (PAHO) TriVac SUPR ADIP PAHO TriVac SUPR ADIP PAHO TriVac SUPR
  D S D/S D S D S D/S D S D S D/S D S
Outcomes:                
Life years gained 5,657 1,228 18,500a 1,511 1,781 109,405 22,584 295,344a 1,511 2,228 17,568 7,648 99,204a 1,511 3,847
Death averted - - 567a 18 30 - - 8,786a 18 32 - - 2,924a 18 53
QALYs gained - -   2,438 3,523 - - - 2,438 4,123 - - - 2,438 5,474
DALYs averted 5,681 1,254 18,950a - - 109,839 23,084 301,953a - - 17,640 7,761 100,736a - -
Costs (US$):                
Incremental cost per live birth population -74,020 4,863,640 72,796,429 61,454,589 -36,736,421 84,234,567 83,385,318 1,025,138,030 61,454,589 40,278,151 -540,048 10,300,512 160,611,146 61,454,589 -28,181,083
Incremental cost per person -1.23 80 60 84 -607 90 89 55 84 43 -3.85 73 57 84 -201
Incremental cost-effectiveness ratio (US$):                
Incremental cost per DALYs averted - 3,878 3,842 - - 767 3,612 3,395 - - - 1,327 1,594 - -
Incremental cost per life year gained - 3,961 3,935 40,683 - 770 3,692 3,471 40,683 18,081 - 1,347 1,619 40,683 -
Incremental cost per death averted - 127,290 - - - 25,763 123,289 - - - - 45,206 - - -
Incremental cost per case averted - - 1,348 -   - - 1,311 - - - - 1,324 - -
Incremental cost per hospitalization averted - - 9,278 - - - - 10,706 - - - - 9,047 - -
Incremental cost per death averted - - 128,397 3,336,028 - - - 116,673 3,336,028 1,276,894 - - 54,935 3,336,028 -
Incremental cost per QALYs - - - 25,210 - - - - 25,210 9,770 - - - 25,210 -
  1. Default means the outputs using the predefined model inputs. Standardized means the outputs using the standardized model input.
  2. aPer 20 cohorts.
  3. ADIP = Pneumo ADIP; SUPR = Supremes; D = default; S = standardized