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Table 4 Outputs of all three models using standardized set of input parameters for hypothetical countries in the subA-Saharan African (SSA) region, Southeast Asian (SEA) region and Latin America and the Caribbean (LAC) region

From: Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools

 

Hypothetical country, SSA region

Hypothetical country, SEA region

Hypothetical country, LAC region

Results

ADIP

Pan-American Health Organization (PAHO) TriVac

SUPR

ADIP

PAHO TriVac

SUPR

ADIP

PAHO TriVac

SUPR

 

D

S

D/S

D

S

D

S

D/S

D

S

D

S

D/S

D

S

Outcomes:

               

Life years gained

5,657

1,228

18,500a

1,511

1,781

109,405

22,584

295,344a

1,511

2,228

17,568

7,648

99,204a

1,511

3,847

Death averted

-

-

567a

18

30

-

-

8,786a

18

32

-

-

2,924a

18

53

QALYs gained

-

-

 

2,438

3,523

-

-

-

2,438

4,123

-

-

-

2,438

5,474

DALYs averted

5,681

1,254

18,950a

-

-

109,839

23,084

301,953a

-

-

17,640

7,761

100,736a

-

-

Costs (US$):

               

Incremental cost per live birth population

-74,020

4,863,640

72,796,429

61,454,589

-36,736,421

84,234,567

83,385,318

1,025,138,030

61,454,589

40,278,151

-540,048

10,300,512

160,611,146

61,454,589

-28,181,083

Incremental cost per person

-1.23

80

60

84

-607

90

89

55

84

43

-3.85

73

57

84

-201

Incremental cost-effectiveness ratio (US$):

               

Incremental cost per DALYs averted

-

3,878

3,842

-

-

767

3,612

3,395

-

-

-

1,327

1,594

-

-

Incremental cost per life year gained

-

3,961

3,935

40,683

-

770

3,692

3,471

40,683

18,081

-

1,347

1,619

40,683

-

Incremental cost per death averted

-

127,290

-

-

-

25,763

123,289

-

-

-

-

45,206

-

-

-

Incremental cost per case averted

-

-

1,348

-

 

-

-

1,311

-

-

-

-

1,324

-

-

Incremental cost per hospitalization averted

-

-

9,278

-

-

-

-

10,706

-

-

-

-

9,047

-

-

Incremental cost per death averted

-

-

128,397

3,336,028

-

-

-

116,673

3,336,028

1,276,894

-

-

54,935

3,336,028

-

Incremental cost per QALYs

-

-

-

25,210

-

-

-

-

25,210

9,770

-

-

-

25,210

-

  1. Default means the outputs using the predefined model inputs. Standardized means the outputs using the standardized model input.
  2. aPer 20 cohorts.
  3. ADIP = Pneumo ADIP; SUPR = Supremes; D = default; S = standardized