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Table 3 Summary estimates of sensitivity, specificity, positive likelihood ratio (LR) and negative LR for the Centor score, calculated using a bivariate random effects model

From: Predicting streptococcal pharyngitis in adults in primary care: a systematic review of the diagnostic accuracy of symptoms and signs and validation of the Centor score

Centor score No. of studies Sensitivity (95% CI) Specificity (95% CI) + LR (95% CI) - LR (95% CI)
≥ 1 11 0.95 (0.91 to 0.97) 0.18 (0.12 to 0.26) 1.16 (1.08 to 1.25) 0.27 (0.16 to 0.46)
≥ 2 12 0.79 (0.71 to 0.86) 0.55 (0.45 to 0.65) 1.76 (1.51 to 2.07) 0.37 (0.29 to 0.48)
≥ 3 11 0.49 (0.38 to 0.60) 0.82 (0.72 to 0.88) 2.68 (1.92 to 3.75) 0.62 (0.52 to 0.74)
4 11 0.18 (0.12 to 0.27) 0.95 (0.92 to 0.97) 3.85 (2.05 to 7.24) 0.86 (0.78 to 0.93)