Table 1 Clinical studies evaluating outcome of lifestyle interventions for obese adults and children with NAFLD
From: The role of lifestyle changes in the management of chronic liver disease
Author | Patients (n) | Study type | Therapy | Duration | Outcome |
|---|---|---|---|---|---|
Franzese et al. [38] | 58 | Case series | Diet and exercise | Six months | 85% of patients with NAFLD (19/33) with normalization or improvement in US findings of NAFLD |
Huang et al. [11] | 23 | Pilot study | Diet | one year | NASH improved In 60% of patients |
Johnson, NA [10] | 19 | Randomized, controlled trial | Exercise | four weeks | Reduction of hepatic triglyceride concentration, visceral adipose tissue volume and hepatic free fatty acids |
Nobili V et al. [16] | 53 | Randomized, controlled trial | Diet and exercise | 24 months | Children experienced weight loss and improved liver histology after lifestyle intervention |
Oza et al. [39] | 22 | Pilot study | Diet | six months | BMI and steatosis reduced in 86% of patients who completed the study (only 32% of patients completed the study) |
Palmer et al. [40] | 39 | Case series | Diet and exercise | 2 to 111 months | Liver enzymes improved in patients with weight loss |
Promrat et al. [37] | 31 | Randomized, controlled trial | Diet and exercise | 48 weeks | More patients with lifestyle intervention had reduction in NAS score in comparison with control group |
St. George et al. [9] | 152 | Randomized trial | Diet and exercise | three months | Reduction of liver enzymes in both the low-intensity and moderate-intensity groups |
Ueno et al. [8] | 25 | Non-randomized, controlled trial | Diet and exercise | three months | Steatosis improved in the intervention group |
Viljanen et al. [12] | 34 | Case Series | Diet | six weeks | Decreased liver volume and liver fat content, improved hepatic insulin resistance |