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Table 1 Clinical characteristics of the included studies

From: FTO gene polymorphisms and obesity risk: a meta-analysis

Study Publication year Country Ethnicity Case Control
     Mean age (SD)
(years)
Mean BMI (SD)
(kg/m 2)
Mean age (SD)
(years)
Mean BMI (SD) (kg/m 2)
Frayling_a [4]a 2007 UK Caucasian NAg NA 28.4 (4.7) 22.7
Frayling_b 2007 UK Caucasian NA NA 31.0 24.4
Frayling_c 2007 UK Caucasian NA NA 40.6 (6.1) 25.6
Frayling_d 2007 UK Caucasian NA NA 56.7 (4.5) 26.4
Frayling_e 2007 UK Caucasian 60.1 (8.8) 32.8 59.7 (9.0) 26.1
Frayling_f 2007 UK Caucasian NA NA 68.8 (5.5) 27.2
Frayling_g 2007 UK Caucasian NA NA 74.3 (6.9) 27.2
Hinney [43]b 2007 Germany Caucasian 14.4 (3.7) 33.4 (6.8) 26.1 (5.8) 18.3 (1.1)
Dina_a [6] 2007 France Caucasian 44 (12) 47 (7.6) 51 (10) 22.8 (2)
Dina_b 2007 France Caucasian 10.6 (3.5) NA 49 (5.5) 22.3 (2.3)
Dina_c 2007 France Caucasian 11.8 (3.1) 29.8 (5.8) 22.0 (3.7) 21.1 (2.0)
Dina_d 2007 Switzerland Caucasian NA 46.7 (5.5) NA NA
Dina_e 2007 Germany Caucasian 11.6 (2.7) NA 11.7 (1.7) NA
Song_H [31]c 2007 USA Hispanic NA NA 61.1 (6.71) 30.9 (7.1)
Song_AP 2007 USA Asian NA NA 60.2 (6.77) 29.0 (5.78)
Song_B 2007 USA African NA NA 63.8 (7.58) 24.7 (4.49)
Villalobos [40] 2008 Mexico South American 43.9 (13.1) 39.4 (8.6) NA NA
Chang [35] 2008 China-Taiwan Asian 37.0 (0.56) 38.9 (8.2) 61.1 (0.33) 24.0 (2.9)
Hotta [37] 2008 Japan Asian 49.1 (14.2) 34.5 (5.4) 48.2 (16.5) 21.7 (2.1)
Li [15] 2008 China Asian NA NA 58.6 (6.0) 24.2
Peeters [41] 2008 Belgium Caucasian NA 38.3 (0.3) NA NA
Jacobsson_2008 [42] 2008 Sweden Caucasian 12.6 (3.3) 35.4 (6.6) 17.1 (0.8) 21.1 (2.6)
Muler [44]d 2008 Germany Caucasian 10.7 (3.1) 28.9 (5.2) 24.6 (2.6) 21.8 (1.1)
Andreasen_a [45] 2008 Denmark Caucasian NA NA 46.2 (7.9) 26.3 (4.6)
Andreasen_be 2008 Denmark Caucasian NA NA 60.0 (6.8) 28.6 (4.9)
Andreasen_c 2008 Denmark Caucasian NA NA 58.5 (8.1) 26.5 (4.2)
Grant_C [51] 2008 USA Caucasian 2-18 BMI ≥95th percentile 2-18 BMI<95th percentile
Grant_AA 2008 USA African 2-18 BMI ≥95th percentile 2-18 BMI<95th percentile
Price [33] 2008 USA Caucasian 41.1 (9.4) 49.1 (8.8) 42.6 (8.8) 20.8 (1.8)
Legry [36] 2008 France Caucasian 52.9 (8.2) 33.8 (3.5) 48.9 (8.5) 22.5 (1.8)
Gonzalez [39] 2009 Spain Hispanic 58.0 (11.0) 33.0 (3.3) 54.0 (11.0) 25.8 (2.6)
Zabena [38] 2009 Spain Hispanic 44.8 (12.5) 45.5 (7.4) 45.5 (7.3) 24.3 (2.4)
Tabara [32]f 2009 Japan Asian NA NA 61.0 (14.0) 23.4 (3.2)
Attaoua [49] 2009 France Caucasian 39.1 (11.4) 39.4 (3.8) 39.6 (11.6) 23.8 (2.6)
Meyre_FC [50] 2009 France Caucasian 11.5 (3.1) 29.0 (9.8) 21.0 (4.5) 20.74 (2.2)
Meyre_FA 2009 France Caucasian 41.1 (10.9) 49.4 (7.8) 49.1 (5.5) 22.3 (2.3)
Meyre_SA 2009 Switzerland Caucasian 42.4 (11.5) 43.7 (7.2) NA NA
Meyre_GC 2009 Germany Caucasian 11.8 (2.9) 29.7 (9.2) 11.8 (2.9) 18.15 (8.1)
Thorleifsson [52] 2009 Mixed Mixed NA NA NA NA
Willer [34] 2009 Mixed Mixed NA NA NA NA
Renstrom [53] 2009 Sweden Caucasian 52.6 (9.5)h >30 52.6 (9.5) h 18.5-24.9
Jacobsson_2009 [47] 2009 Sweden Caucasian 50.0 (0) 32.1 (1.9) 50.0 (0) 24.8 (1.8)
Karasawa [48]f 2010 Japan Asian NA NA 63.0 (1.2) 23.5 (3.2)
Liu [46] 2010 China Asian NA NA 58.0 (9.0) 24.5 (3.2)
Cheung [30] 2010 China Asian 46.3 (11.9) 32.2 (4.9) 45.0 (12.5) 21.2 (1.2)
  1. a: The article by Frayling et al. contains seven studies, namely Frayling _a (ALSPAC), Frayling _b (NFBC1966), Frayling _c (Oxford Biobank), Frayling _d (Caerphilly), Frayling _e (EPIC-Norfolk), Frayling _f (BWHHS), and Frayling _g (InCHIANTI). Please refer to the original article [4] for details.
  2. b: Early-onset, extremely obese cases (mean BMI Z score 4.63 ± 2.27) and healthy, underweight controls (mean BMI Z score -1.38 ± 0.35; BMI <15thage percentile).
  3. c: The age and BMI values are reported as the mean value of all case and control subjects.
  4. d: Obese cases are reported as the 99.5th percentile of the median age and gender-specific BMI. Lean controls are reported as the 51.0st percentile of the median age and gender-specific BMI.
  5. e: The article by Andreasen et al. contains three studies, including Andreasen_a (Population-based, Inter99 study sample), Andreasen_b
  6. (ADDITION study cohort), and Andreasen_c (SDC control group). For details, please refer to the original article [45].
  7. f: In Japan, obesity is defined as a condition in which the individuals had a BMI ≥25 kg/m2 according to the guidelines of the Japanese Society for the Study of obesity [68].
  8. g: Not available.
  9. h: The mean age of all subjects (non-diabetic individuals).