Skip to main content

Table 2 Genotypic distributions and ORs for the association between five polymorphisms and obesity

From: FTO gene polymorphisms and obesity risk: a meta-analysis

Study N (case/control) OR [95% CI], P-value
  Subtotal MAF PHWE 11a 12 22 Additive model Allelic comparison
rs9939609
Caucasian:         
Frayling_a 5,380 (353/5,027) 0.48/0.39 0.513 107/1,879 157/2,407 89/741 1.43 (1.23 to 1.67) 1.43 (1.23 to 1.67)
Frayling_b 3,072 (415/2,657) 0.45/0.37 0.185 132/1,060 193/1,211 90/386 1.36 (1.18 to 1.57) 1.37 (1.18 to 1.59)
Frayling_c 487 (126/361) 0.42/0.38 0.575 45/138 56/175 25/48 1.21 (0.90 to 1.62) 1.21 (0.91 to 1.61)
Frayling_d 623 (200/423) 0.41/0.34 0.447 67/189 101/182 32/52 1.37 (1.07 to 1.75) 1.37 (1.08 to 1.76)
Frayling_e 2,511 (1,588/923) 0.43/0.38 0.625 485/351 847/443 256/129 1.24 (1.10 to 1.40) 1.22 (1.09 to 1.37)
Frayling_f 1,875 (840/1,035) 0.42/0.37 0.547 274/421 427/471 139/143 1.26 (1.10 to 1.44) 1.25 (1.10 to 1.43)
Frayling_g 461 (212/249) 0.47/0.42 0.514 66/82 92/127 54/40 1.25 (0.97 to 1.61) 1.26 (0.97 to 1.63)
Andreasen_a 3,724 (1,045/2,679) 0.45/0.39 0.103 313/993 517/1,309 215/377 1.33 (1.20 to 1.48) 1.32 (1.19 to 1.47)
Andreasen_b 4,671 (2,819/1,852) 0.43/0.39 0.221 911/684 1,385/904 523/264 1.21 (1.11 to 1.31) 1.20 (1.11 to 1.31)
Andreasen_c 377 (104/273) 0.45/0.39 0.076 30/93 55/145 19/35 1.27(0.91 to 1.80) 1.25 (0.90 to 1.72)
Muler 697 (519/178) 0.50/0.44 0.763 140/56 238/86 141/36 1.24 (0.98 to 1.57) 1.26 (0.99 to 1.60)
Price 1,047 (527/520) 0.48/0.36 0.084 152/207 242/257 133/56 1.69 (1.41 to 2.02) 1.69 (1.42 to 2.02)
Peeters 1,367 (1,099/268) 0.46/0.40 0.703 316/94 553/133 230/41 1.28 (1.05 to 1.56) 1.28 (1.05 to 1.55)
Jacobsson_2008 960 (450/510) 0.48/0.42 0.716 133/174 206/244 111/92 1.24 (1.04 to 1.48) 1.25 (1.05 to 1.50)
Legry 3,367 (598/2,769) 0.46/0.41 0.050 171/924 307/1,395 120/450 1.20 (1.05 to 1.36) 1.19 (1.05 to 1.35)
Jacobsson_2009 1,115 (54/1,061) 0.44/0.39 0.218 16/411 29/483 9/167 1.22 (0.83 to 1.80) 1.23 (0.83 to 1.82)
Hinney 926 (484/442) 0.50/0.39 0.690 123/164 241/214 120/64 1.57 (1.30 to 1.90) 1.57 (1.30 to 1.88)
Asian:         
Song_AP 240 (77/163) 0.20/0.17 0.409 50/114 23/43 4/6 1.23 (0.76 to 1.97) 1.24 (0.76 to 2.03)
Chang 2,135 (610/1,525) 0.17/0.13 0.355 425/1,158 167/347 18/20 1.38 (1.15 to 1.66) 1.37 (1.14 to 1.5)
Hotta 2,423 (919/1,504) 0.24/0.19 0.393 534/1,005 334/443 51/56 1.37 (1.19 to 1.58) 1.66 (1.31 to 2.11)
Tabara 1,718 (214/1,504) 0.22/0.16 0.438 128/1,063 77/408 9/33 1.54 (1.20 to 1.99) 1.53 (1.19 to 1.95)
Karasawa 2,639 (794/1,845) 0.23/0.20 0.373 477/1,203 271/566 46/76 1.22 (1.06 to 1.41) 1.23 (1.06 to 1.42)
Liu 1,167 (276/891) 0.14/0.11 0.396 201/701 70/181 5/8 1.38 (1.04 to 1.83) 1.36 (1.03 to 1.80)
Li 3,210 (398/2,812) NA/0.12 NA NA NA NA 0.90 (0.70 to 1.15) NA
Hispanic:         
Song_H 415 (139/276) 0.27/0.31 0.157 75/138 53/107 11/31 0.85 (0.62 to 1.16) 0.84 (0.61 to 1.15
Gonzalez 725 (207/518) 0.45/0.37 0.925 62/203 104/244 41/71 1.38 (1.09 to 1.74) 1.37 (1.09 to 1.73)
Zabena 255 (75/180) 0.52/0.34 1.0 19/78 34/81 22/21 2.04 (1.38 to 3.02) 2.09 (1.42 to 3.07)
African:         
Song_B 1,114 (365/749) 0.47/0.45 0.160 113/239 161/351 91/159 1.09 (0.92 to 1.30) 1.10 (0.92 to 1.31)
South American:         
Villalobos 788 (364/424) 0.25/0.17 0.598 209/297 127/114 28/13 1.66 (1.31 to 2.11) 1.7 (1.33 to 2.17)
Mixed:         
Willer 19,367 (5,261/14,106) NA NA NA NA NA NA 1.25 (1.19 to 1.31)
Total N (rs9939609) 68,856 (21,132/47,724)      Pooled ORs 1.31 (1.25 to 1.37) 1.31 (1.26 to 1.36)
rs1421085
Causian:         
Dina_a 3,557 (867/2,690) 0.52/0.41 0.218 200/944 425/1,273 242/473 1.55 (1.39 to 1.73) 1.57 (1.41 to 1.75)
Dina_b 1,678 (699/979) 0.51/0.42 0.896 173/323 334/481 192/175 1.42 (1.24 to 1.63) 1.43 (1.25 to 1.64)
Dina_c 1,001 (482/519) 0.51/0.41 0.205 119/187 233/237 130/95 1.47 (1.24 to 1.75) 1.50 (1.26 to 1.79)
Dina_d 1,018 (504/514) 0.52/0.46 0.051 123/161 235/233 146/120 1.26 (1.07 to 1.49) 1.29 (1.08 to 1.53)
Dina_e 551 (283/268) 0.53/0.40 0.637 62/246 142/343 79/110 1.69 (1.38 to 2.06) 1.67 (1.37 to 2.04)
Peeters 1,367 (1,099/268) 0.48/0.41 0.900 300/93 544/129 255/46 1.31 (1.08 to 1.59) 1.31 (1.09 to 1.59)
Attaoua 248 (119/129) 0.55/0.41 0.585 24/47 58/59 37/23 1.78 (1.24 to 2.54) 1.81 (1.27 to 2.59)
Meyre_FC 1,036 (491/545) 0.49/0.41 0.077 137/197 231/244 123/104 1.31 (1.11 to 1.55) 1.33 (1.12 to 1.59)
Meyre_FA 859 (132/727) 0.51/0.43 0.820 31/238 67/359 34/130 1.42 (1.09 to 1.85) 1.41 (1.09 to 1.84)
Meyre_SA 1,346 (1,028/318) 0.50/0.46 0.055 286/100 460/141 282/77 1.13 (0.96 to 1.34) 1.15 (0.96 to 1.37)
Meyre_GC 1,080 (370/710) 0.55/0.45 0.081 76/227 181/328 113/155 1.47 (1.23 to 1.75) 1.50 (1.25 to 1.79)
Total N (rs1421085) 13,741 (6,074/7,667)      Pooled ORs 1.41 (1.31 to 1.51) 1.43 (1.33 to 1.53)
rs8050136
Caucasian:         
Hinney 928 (486/442) 0.50/0.39 0.842 123/165 240/212 123/65 1.58 (1.31 to 1.91) 1.59 (1.32 to 1.91)
Grant_C 2,688 (418/2,270) 0.45/0.39 NA NA NA NA NA 1.27 (1.09 to 1.47)
Asian:         
Song_AP 240 (77/163) 0.20/0.18 0.425 52/111 20/45 5/7 1.09 (0.68 to 1.73) 1.10 (0.67 to 1.78)
Cheung 1,159 (468/691) 0.16/0.12 0.463 326/535 131/149 11/7 1.48 (1.16 to 1.89) 1.46 (1.15 to 1.85)
Liu 1,180 (278/902) 0.15/0.11 0.489 201/716 73/178 4/8 1.43 (1.08 to 1.91) 1.42 (1.07 to 1.87)
Li 3,210 (398/2,812) NA/0.12 NA NA NA NA 0.91 (0.71 to 1.16) NA
African:         
Song_B 1,114 (365/749) 0.42/0.42 0.454 133/257 161/355 71/137 0.98 (0.82 to 1.17) 0.98 (0.82 to 1.17)
Grant_AA 2,002 (578/1,424) 0.45/0.44 NA NA NA NA NA 1.05 (0.91 to 1.21)
Mixed:         
Thorleifsson 22,277 (13,785/8,492) NA NA NA NA NA NA 1.27 (1.21 to 1.32)
Total N (rs8050136) 34,798 (16,853/17,945)      Pooled ORs 1.22 (0.99 to 1.51) 1.25 (1.13 to 1.38)
rs17817449
Caucasian:         
Dina_a [6] 3,548 (873/2,675) 0.49/0.60 0.968 212/948 426/1,288 235/439 1.55 (1.39 to 1.72) 1.55 (1.39 to 1.73)
Dina_b 1,589 (689/900) 0.47/0.59 0.600 164/337 320/489 205/164 1.59 (1.38 to 1.83) 1.60 (1.40 to 1.84)
Dina_c 1,010 (485/525) 0.49/0.60 0.173 120/196 236/237 129/92 1.52 (1.28 to 1.81) 1.55 (1.30 to 1.85)
Dina_d 1,035 (516/519) 0.50/0.55 0.374 138/164 243/246 135/109 1.21 (1.02 to 1.43) 1.22 (1.03 to 1.45)
Dina_e 972 (281/691) 0.46/0.58 0.755 58/231 142/341 81/119 1.65 (1.35 to 2.01) 1.63 (1.34 to 1.99)
Price 1,049 (527/522) 0.49/0.36 0.087 145/205 247/259 135/58 1.72 (1.44 to 2.06) 1.72 (1.44 to 2.05)
Total N (rs17817449) 9,203 (3,371/5,832)      Pooled ORs 1.53 (1.40 to 1.67) 1.54 (1.41 to 1.68)
rs1121980
Caucasian:         
Hinney 926 (484/442) 0.53/0.41 0.694 104/153 247/218 133/71 1.66 (1.37 to 2.01) 1.64 (1.37 to 1.97)
Renstrom 1,723 (353/1,370) NA NA NA NA NA NA 1.15 (1.05 to 1.25)
Asian:         
Hotta 2,451 (927/1,524) 0.26/0.21 0.593 499/947 367/504 61/73 1.32 (1.15 to 1.51) 1.32 (1.16 to 1.51)
Total N (rs1121980) 5,100 (1,764/3,336)      Pooled ORs 1.46 (1.17 to 1.83) 1.34 (1.10 to 1.62)
Total Subjects (duplicated subjects were excluded) 112,327 (42,616/69,711)
  1. a: 11, 12, and 22 denote TT, TA, and AA for rs9939609; TT, TC, and CC for rs1421085; CC, CA, and AA for rs8050136; TT, TG, and GG for rs17817449; and GG, GA, and AA for rs1121980.