Class | Generic name, formulation and brand name | Daily dosage | Duration | Mechanism of action | Common Side-effects |
---|---|---|---|---|---|
 |  | STIMULANTS |  |  |  |
Methylphenidate | Immediate-release/short-acting (Ritalin, Methylin, Desoxyn) | Initial 5-18 mg; increase as needed until beneficial effects peak or unacceptable side effects develop Two to three times daily; can titrate as needed as long as beneficial effects are greater than side effects | 3 to 6 hours | Blocks reuptake of D, N Release of D from storage vesicles | Appetite suppression, delay of sleep onset, abdominal pain, headache, rebound irritability, tics (motor, vocal), jitteriness |
 | Intermediate-acting (Metadate ER, Metadate CD, Methyllin ER, Ritalin LA, Ritalin SR) | One to two times daily | 3 to 8 hours | Same | Same |
 | Extended release/long-acting (Concerta, Daytrana Patch) | Once daily (Patch left on for 9 hrs) | 8 to 12 hours | Same | Same |
Dexmethylphenidate | Short-acting (Focalin) | Two to three times daily; initial half that of IR MPH | 4 to 5 hours | Same | Same |
 | Extended-release/long-acting (Focalin XR) | Once daily | 8 to 12 hours | Same | Same |
Amphetamines | Immediate-release/short-acting (Dexedrine, DextroStat, Adderall) | Initial dose half IR MPH; two to three times daily | 4 to 6 hours | Release of D newly synthesized D; blocks reuptake of D, N | Same |
 | Intermediate-acting (Dexedrine spansule) | One to two times daily | 6 to 10 hours | Same | Same |
 | Extended-release/long-acting (Adderall-XR) | Once daily | 8 to 12 hours | Same | Same |
Prodrug Amphetamines | Lisdexamfetamine (Vyvanse) | Initial 4 × IR MPH once daily | 8 to 12 hours | Same | Same |
 |  | NON - STIMULANTS |  |  |  |
NRI | Atomoxetine (Strattera) | Initial 0.5 mg/Kg; Increase to 1.2-1.8 mg/Kg one to 2 times a day | 18 to 24 hours | Blocks N reuptake at synapse | Sedation, GI irritability, palpitations, sweating, increased suicidal thoughts |
 |  | ALPHA2 AGONISTS |  |  |  |
Clonidine | IR Clonidine (Catapres) | Initial dose 0.05-0.1 mg at night; titrate to max 0.4 mg/per day | 3 to 6 hours | Arousal at locus ceruleus by N inhibition | Sedation, Low blood pressure, rebound hypertension |
 | ER Clonidine (Kapvay) | Initial 0.1 mg qhs; titrate to max 0.4 mg qhs; once daily | 12 to 24 hours | Same | Same |
 | Clonidine patch (catapres TDS) | Initial TTS-1 up to TTS-3 | 1 to 5 days | Same | Same |
Guanfacine | IR Guanfacine (Tenex) | Initial 1 mg daily; titrate as needed up to 4 mg MDD; twice daily | 12 to 24 hours | Same | Same |
 | ER guanfacine (Intuniv) | Initial 1 mg; up to 4 mg; once daily | ~24 hours | Same | Same |
 |  | ANTIDEPRESSANTS |  |  |  |
NDRI | Buproprion | Initial: lesser of 3 mg/Kg/d or 150 mg; Maximum: Lesser of 6 mg/Kg/d or 450 mg; No singled does greater than 150 mg; 2 to 3 times a day | 8 to 12 hours | N and D reuptake inhibition | Insomnia, decreased appetite, irritability, anticholinergic (dry mouth, GI etc.), decreased seizure threshold |
 | IR (Wellbutrin) |  |  | Same | Same |
 | ER (Wellbutrin SR) | Twice daily | 12 to 24 hours | Same | Same |
 | (Wellbutrin XL) | Once daily | 24 hours | Same | Same |
SNRI's (Tricyclics) | Imipramine (Tofranil) | Initial: 1 mg/Kg/d; Maximum: Lesser of 4 mg/Kg/d or 200 mg; 1 to 2 times per day; obtain baseline EKG; Monitor serum levels | 12 to 24 hours | N and Serotonin reuptake blockade | Sedation, Cardiac increase heart rate, arrhythmias, anticholinergic (dry mouth, GI, etc.), blurry vision |