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Table 3 Multiple logistic regression to assess the associations of types of intervention, time before and after CONSORT and impact of journal with aspects of trial design, conduct and analysis

From: High prevalence of potential biases threatens the interpretation of trials in patients with chronic disease

  Drug versus non-drug From 2001 versus before 2001 Per increase of 1 unit in impact factor
Reporting of between-group comparisons 2.39 (0.46 to 12.50) (0.30) 2.73 (0.63 to 11.90) (0.18) 1.19 (0.95 to 1.49) (0.14)
Primary outcome reported 8.15 (3.16 to 21.03) (< 0.001) 8.46 (3.18 to 22.49) (< 0.001) 1.06 (1.01 to 1.11) (0.010)
Primary outcome is only one measure 4.19 (1.68 to 10.46) (0.002) 5.81 (2.17 to 15.59) (< 0.001) 1.04 (1.01 to 1.08) (0.018)
No statistical comparison of baseline characteristics 2.48 (1.11 to 5.56) (0.027) 0.97 (0.46 to 2.03) (0.93) 1.0 2 (0.98 to 1.06) (0.30)
Reporting of handling of missing data 1.79 (0.74 to 4.32) (0.20) 2.47 (1.00 to 6.10) (0.049) 1.03 (1.00 to 1.06) (0.07)
Intention-to-treat analysis reported 2.88 (1.39 to 5.99) (0.005) 2.02 (0.99 to 4.15) (0.055) 1.03 (0.99 to 1.06) (0.11)
Reporting of P values and 95% CI (n) 1.85 (0.81 to 4.24) (0.15) 1.83 (0.79 to 4.22) (0.16) 1.07 (1.03 to 1.12) (< 0.001)
  1. Data are odds ratios (95% CI) (P value)