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Table 6 Proportion of reported symptoms in prevalent cases, according to study case definitionsa

From: Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care

Current symptoms All cases (n = 265) CDC-1994 (n = 258) Canadian (n = 142) ECD (n = 43)
Sleep dysfunction Unrefreshing sleep 97.4 97.3 100.0 97.7
  Sleep problems 84.9 85.3 94.4 73.0
Neurological/Cognitive manifestations Memory/concentration problems 94.3 95.3 98.0 95.3
  Difficulty thinking 81.5 82.0 93.0 74.4
  Unexplained muscle weakness 75.1 74.8 88.0 70.0
  Light/noise sensitivity 65.7 66.0 82.4 65.1
  Difficulty in understanding things 58.1 59.3 76.1 48.8
  Confusion or disorientation 54.7 55.0 78.2 44.2
Pain Pain in two or more joints 89.8 91.1 94.4 76.7
  Muscle pain 88.9 89.5 95.1 74.4
  Muscle discomfort 86.8 88.0 94.4 76.7
  Migratory joint pain 75.8 76.4 85.2 53.5
  Headaches 64.5 65.5 74.6 60.5
  Migraine 28.3 28.3 36.6 25.6
Fatigue/tiredness Fatigue after exercise (> 24 hours) 81.1 80.6 100.0 90.7
  Intolerance to exercise 71.7 71.7 85.2 81.4
  Malaise after exertion (> 24 hours) 69.1 69.4 85.9 86.0
Psychological Anxiety 70.9 72.5 83.1 39.5
  Depression 55.8 56.2 67.6 11.6
Autonomic Sweatiness/cold hands and feet 66.4 67.4 88.0 55.8
  Intolerance to be on your feet 61.1 60.8 79.6 55.8
Immunological Sore throat 57.0 56.7 71.8 60.5
  Tender glands in the neck/armpits 57.0 57.7 74.6 55.8
  Mild fever or chills 52.8 52.7 75.3 46.5
  1. aAll cases complying with each of the definitions are shown in the columns; therefore cases meeting more than one diagnostic criterion appear more than once.