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Table 2 Probiotic protocols from trials included in the updated meta-analysis

From: Evidence-based guidelines for use of probiotics in preterm neonates

Study Probiotic agent/s Dose and duration
Kitajima 1997 [52] Bifidobacterium breve 0.5 × 109 cfua once daily from first feed for 28 days.
Dani 2002 [53] Lactobacillus rhamnosus GG 6 × 109 cfu once daily from first feed until discharge
Costalos 2003 [54] Saccharomyces boulardii 109/kg twice daily from first feed for 30 days
Bin Nun 2005 [55] Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidus 0.35 × 109 cfu B. infantis, 0.35 × 109 cfu S. thermophilus and 0.35 × 109 cfu B. bifidus once daily from first feed to 36 weeks corrected age
Lin 2005 [56] Lactobacillus acidophilus, B. infantis 1004356 L. acidophilus and 1015697 B. infantis organisms twice daily from day 7 until discharge
Manzoni 2006 [57] Lactobacillus casei 6 × 109 cfu once daily from 3 days to 6 weeks of age, or discharge from NICUb
Mohan 2006 [28] Bifidobacterium lactis 1.6 × 109 cfu once daily from day 1 to day 3; 4.8 × 109 cfu once daily from day 4 to day 21
Stratiki 2007 [59] B. lactis Preterm formula: 1 × 107 cfu/g started within 48 hours to 30 days
Lin 2008[60] B. bifidus, L. acidophilus 2 × 109 cfu daily for 6 weeks
Samanta 2009[61] B. bifidus, B. lactis, B. infantis, L.s acidophilus 2.5 × 109 cfu daily until discharge
Rouge 2009 [62] Bifidobacterium longum, Lactobacillus GG 1 × 108 cfu daily until discharge
  1. aColony-forming units.
  2. bNeonatal intensive-care unit.