Table 2 Probiotic protocols from trials included in the updated meta-analysis
From: Evidence-based guidelines for use of probiotics in preterm neonates
Study | Probiotic agent/s | Dose and duration |
|---|---|---|
Kitajima 1997 [52] | Bifidobacterium breve | 0.5 × 109 cfua once daily from first feed for 28 days. |
Dani 2002 [53] | Lactobacillus rhamnosus GG | 6 × 109 cfu once daily from first feed until discharge |
Costalos 2003 [54] | Saccharomyces boulardii | 109/kg twice daily from first feed for 30 days |
Bin Nun 2005 [55] | Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidus | 0.35 × 109 cfu B. infantis, 0.35 × 109 cfu S. thermophilus and 0.35 × 109 cfu B. bifidus once daily from first feed to 36 weeks corrected age |
Lin 2005 [56] | Lactobacillus acidophilus, B. infantis | 1004356 L. acidophilus and 1015697 B. infantis organisms twice daily from day 7 until discharge |
Manzoni 2006 [57] | Lactobacillus casei | 6 × 109 cfu once daily from 3 days to 6 weeks of age, or discharge from NICUb |
Mohan 2006 [28] | Bifidobacterium lactis | 1.6 × 109 cfu once daily from day 1 to day 3; 4.8 × 109 cfu once daily from day 4 to day 21 |
Stratiki 2007 [59] | B. lactis | Preterm formula: 1 × 107 cfu/g started within 48 hours to 30 days |
Lin 2008[60] | B. bifidus, L. acidophilus | 2 × 109 cfu daily for 6 weeks |
Samanta 2009[61] | B. bifidus, B. lactis, B. infantis, L.s acidophilus | 2.5 × 109 cfu daily until discharge |
Rouge 2009 [62] | Bifidobacterium longum, Lactobacillus GG | 1 × 108 cfu daily until discharge |