Figure 2

Forest plots of adjusted mortality in smokers vs. non-smokers. Odds ratios (OR)/hazard ratios (HR) with 95% confidence intervals for death during follow-up for smokers compared with non-smokers in the studies included. Circles indicate data derived from randomised trials. Squares indicate data derived from observational studies or registries. Open symbols indicate contemporary studies enrolling patients mainly after 2000. Closed symbols indicate older studies enrolling patients in the pre-thrombolytic and thrombolytic era. Symbol size reflects the sample size of the studies and registries. *Inverted OR from original paper. ^§The adjusted HR is for the conservative treatment cohort (2003) only. For the invasive cohort (2006) there was no difference in mortality for smokers and non-smokers (data not published).