The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life

Table 1 Sensitivity analysis: the association between baseline ML ratio and TB outcomes holds across TB outcome grouping

Endpoint	Number (cases/at risk)	Multivariable regression adjusted hazard ratio (95% CI)^a	Pvalue
Primary endpoint: TB disease^b or death in HIV + infants; and TB disease^b, death or latent MTB infection in HEU infants	187/1336	1.17 (1.01 to 1.34)	0.03
TB disease^b or death	166^c/1336	1.18 (1.02 to 1.37)	0.02
TB disease^b or latent MTB infection	152/1336	1.21 (1.04 to 1.41)	0.02
TB disease^b	126/1336	1.23 (1.04 to 1.45)	0.02
Probable and definite TB only	49/1336	1.50 (1.19 to 1.89)	0.006
Death	50/1336	1.25 (0.99 to 1.57)	0.06
Latent MTB infection^d	33/725	1.00 (0.66 to 1.5)	0.99

^aEstimated from Cox Proportional Hazard regression models stratified by infant HIV status, modeling ML as linear variable following fractional polynomial exploration, adjusted for weight-for-age z-score, cART receipt at baseline, maternal history of TB, ever breastfed and randomized INH prophylaxis/placebo group. Hazard ratios are per unit increase in the ML ratio. ^bPossible, probable or definite TB. ^cParticipants who had TB disease (possible, probable or definite TB) and subsequently died were only counted once, hence this number is not the sum of the TB disease and death numerators below. ^dLatent MTB infection was only assessed in HEU infants. Text in bold highlights statistically significant findings. cART, combination antiretroviral therapy; CI, confidence interval; HEU, HIV-exposed uninfected; INH, isoniazid; MTB, Mycobacterium tuberculosis; TB, tuberculosis.

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