Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA

Table 3 Sensitivity and specificity of exclusion/inclusion cutoff points of LFS, FLI, and HSI in the cross-sectional NAFLD prediction cohort and literature

NAFLD definition	Non-invasive NAFLD score	Cutoff point		SP, %	95% CI, %	SN, %	95% CI, %	Reported SP, %	Reported SN, %	Ref
No to mild versus intermediate to severe steatosis)	LFS	Inclusion	1.257	96.43	95.82 to 96.98	26.34	23.71 to 29.09	95	51	[7]
	LFS	Exclusion	≤ −1.413	67.94	66.49 to 69.36	73.95	71.20 to 76.56	52	95	[7]
	FLI	Inclusion	60	73.60	72.22 to 74.94	67.48	64.58 to 70.29	86	61	[6]
	FLI	Exclusion	<30	48.77	47.24 to 50.31	84.44	82.13 to 86.57	64	87	[6]
	HSI	Inclusion	36	69.35	67.91 to 70.75	66.26	63.33 to 69.10	92	46	[9]
	HSI	Exclusion	<30	29.75	28.36 to 31.18	91.38	89.53 to 92.99	40	92.50	[9]

AUC, area under the curve; FLI, fatty liver index; HSI, hepatic steatosis index; LAP, lipid accumulation product; LFS, liver fat score; NAFLD, non-alcoholic fatty liver disease; SN, sensitivity; SP, specificity.

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