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Table 5 Association between LFS and mortality

From: Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA

Mortality from: Simple modela Full modelb Full model + NFS adjustmentb
HR 95% CI Pvalue HR 95% CI Pvalue HR 95% CI Pvalue
All causes          
Low (ref) versus high LFS 1.51 0.99 to 2.3 0.056 1.59 0.93 to 2.72 0.087 1.65 0.96 to 2.85 0.07
Int (ref) versus high LFS 1.52 1.03 to 2.23 0.034 1.60 1.01 to 2.54 0.048 1.61 1 to 2.58 0.049
LFS (continuous) 1.07 0.99 to 1.14 0.082 1.09 1.01 to 1.19 0.039 1.1 1.024 to 1.19 0.011
CVD          
Low (ref) versus high LFS 2.29 1.24 to 4.26 0.009 2.24 1.03 to 4.88 0.042 2.30 1.02 to 5.19 0.046
Int (ref) versus high LFS 2.20 1.18 to 4.12 0.015 2.30 1.19 to 4.48 0.015 2.32 1.18 to 4.55 0.015
LFS (continuous) 1.11 1.04 to 1.19 0.002 1.11 1.03 to 1.19 0.006 1.13 1.05 to 1.21 <0.001
Liver disease          
Low (ref) versus high LFS 9.80 2.01 to 47.62 0.006 31.25 3.13 to 333.33 0.004 46.45 5.13 to 420.51 <0.001
Int (ref) versus high LFS 17.24 2.6 to 111.11 0.004 30.30 4-250 0.001 32.99 4.57 to 237.95 <0.001
LFS (continuous) 1.25 1.14 to 1.36 <0.001 1.32 1.12 to 1.55 0.001 1.3 1.12 to 1.51 <0.001
Diabetes          
Low (ref) versus high LFS 15.87 6.02 to 41.67 <0.001 2.87 0.65 to 12.66 0.161 3.13 0.67 to 14.56 0.143
Int (ref) versus high LFS 5.24 2.24 to 12.2 <0.001 1.98 0.71 to 5.52 0.185 2.04 0.72 to 5.79 0.176
LFS (continuous) 1.37 1.27 to 1.48 <0.001 1.21 1.02 to 1.44 0.034 1.21 1.03 to 1.42 0.024
Malignancy          
Low (ref) versus high LFS 0.55 0.25 to 1.24 0.147 0.75 0.27 to 2.11 0.578 0.75 0.27 to 2.09 0.576
Int (ref) versus high LFS 0.65 0.29 to 1.44 0.281 0.76 0.32 to 1.79 0.519 0.76 0.32 to 1.79 0.518
LFS (continuous) 0.92 0.86 to 0.99 0.026 0.97 0.87 to 1.07 0.521 0.95 0.8 to 1.12 0.495
  1. CVD, cardiovascular disease; Int, intermediate; LFS, liver fat score.
  2. aSimple model: adjusted for age and sex.
  3. bFull model: further adjusted for race/ethnicity, education, income, diabetes, hypertension, history of CVD, lipid-lowering medication, smoking status, waist circumference, alcohol consumption, caffeine consumption, total cholesterol, high-density lipoprotein cholesterol, transferrin saturation, and C-reactive protein; Because of smaller numbers of liver- and diabetes-related deaths, we did not adjust for education, income, history of CVD, lipid-lowering medication, and C-reactive protein in the full model.