Weight loss required by the severely obese to achieve clinically important differences in health-related quality of life: two-year prospective cohort study

Table 3 Predicted weight loss thresholds required to achieve MCID HRQL scores

Instrument	Established MCID^a	Relative weight loss required to achieve MCID (% weight loss (95%CI))	Improvement in HRQL achieved with 5%weight loss (points (95%CI))	Improvement in HRQL achieved with 10%weight loss (points (95% CI))
SF-12 PCS	3 to 5^b	23% (17.5, 32.5)	1.10 (0.77, 1.43)	2.20 (1.54, 2.86)
SF-12 MCS	3 to 5^b	25% (17.6, 40.2)	1.02 (0.62, 1.42)	2.04 (1.24, 2.84)
EQ-Index	0.03	9% (6.2, 15.0)	0.017 (0.010, 0.024)	0.034 (0.020, 0.048)
EQ-VAS	10	23% (17.3, 36.1)	2.14 (1.39, 2.89)	4.28 (2.77, 5.79)
IWQOL-Lite Total Score	7 to 12^b	17% (14.1, 20.4)	3.60 (2.94, 4.25)	7.19 (5.88, 8.50)

^aMinimum increase in score considered to be clinically important based upon available published literature; ^bupper value used to estimate minimum weight loss required to achieved MCID. CI, confidence interval; EQ-Index, EQ-5D questionnaire index score; EQ-VAS, EQ-5D questionnaire visual analog scale score; HRQL, health-related quality of life; IWQOL-Lite, Impact of Weight on Quality of Life - Lite questionnaire; MCID, minimal clinically important difference; MCS, mental component summary score; PCS, physical component summary score; SF-12, Short Form 12 questionnaire.

ISSN: 1741-7015