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Table 4 Table for judging the strength of a recommendation[8]

From: Pain care for patients with epidermolysis bullosa: best care practice guidelines

Dimension

Definition

Grade of the body of evidence

High, Moderate, Low, Not Assignable

Safety/harm (side effects and risks)

Minimal, Moderate, Serious

Health benefit to patient

Significant, Moderate, Minimal

Burden on patient to adhere to recommendation

Low, Unable to determine, High

Cost-effectiveness to healthcare system

Cost-effective, Inconclusive, Not cost-effective

Directness of the evidence for this target population

Directly relates, Some concern of directness, Indirectly relates

Impact on morbidity/mortality or quality of life

High, Medium, Low