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Table 4 Table for judging the strength of a recommendation[8]

From: Pain care for patients with epidermolysis bullosa: best care practice guidelines

Dimension Definition
Grade of the body of evidence High, Moderate, Low, Not Assignable
Safety/harm (side effects and risks) Minimal, Moderate, Serious
Health benefit to patient Significant, Moderate, Minimal
Burden on patient to adhere to recommendation Low, Unable to determine, High
Cost-effectiveness to healthcare system Cost-effective, Inconclusive, Not cost-effective
Directness of the evidence for this target population Directly relates, Some concern of directness, Indirectly relates
Impact on morbidity/mortality or quality of life High, Medium, Low