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Table 2 Results of main analysis and subgroup or sensitivity analyses

From: Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

Main analysis

LVMi g/m2

EDVi ml/m2

IVS Mm

VTD mm

Cardiac index L/min/m2

EF%

E/A ratio

NTpro-BNP pg/ml

HR bpm

MAP mmHg

SBP mmHg

DBP mmHg

SVRi dynes m2/sec cm-5

FMD%

WMD

-4.022

0.433

-0.966

-2.666

0.304

3.561

0.053

-161.9

-0.848

-0.413

0.616

-0.763

-88.34

3.306

Lower 95% CI

-10.137

-6.49

-2.230

-7.145

0.202

1.786

-0.275

-351.5

-2.398

-3.023

-1.113

-2.174

-255.75

0.530

Upper 95% CI

2.093

7.357

0.298

1.814

0.406

5.335

0.380

27.6

0.702

2.196

2.345

0.648

79.08

6.082

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----

----

----

----

----

----

----

----

----

----

----

---

Number

306

262

98

99

520

286

116

407

977

355

828

791

232

168

P value

0.197

0.902

0.134

0.243

<0.001

<0.001

0.753

0.094

0.283

0.756

0.490

0.289

0.301

0.020

I-square

96%

94%

95%

90%

0.0%

84%

93%

82%

56%

71%

49%

52%

89%

99%

References

[10]-[12],[14],[25]

[10]-[12],[14]

[11],[25]

[11],[12]

[2],[10],[11],[25],[30],[32],[40]

[10]-[12],[24],[25],[31],[35]

[12],[25],[37]

[10]-[14],[40]

[2],[10],[11],[20],[24],[26],[28],[30],[31],[35],[37],[39]

[10],[23],[25],[30],[31],[38],[39]

[10]-[12],[14],[20],[24],[25],[28],[35],[36],[38]

[10]-[12],[20],[24]-[26],[28],[35],[36],[38]

[10],[25],[30],[31],[39]

[11],[24],[33],[34]

Subgroup/ Sensitivity a

LVMi g/m 2

EDVi ml/m 2

IVS Mm

VTD mm

Cardiac index L/min/m 2

EF %

E/A ratio

NTpro-BNP Pg/ml

HR bpm

MAP mmHg

SBP mmHg

DBP mmHg

SVRi dynes m 2 /sec cm -5

FMD%

LVH

-12.207

   

0.082

4.382

0.053

-486.7

0.829

1.156

0.135

-1.936

55.63

/

Lower 95% CI

-18.846

/

/

/

-0.176

2.059

-0.275

-712,8

-4.526

-2.398

-2.598

-5.309 1.438

-277.86

 

Upper 95% CI

-5.568

   

0.341

6.705

0.380

-260,7

6.185

4.710

2.867

----

389.12

 

---

----

   

----

----

----

----

----

----

----

 

----

 

Number

89

   

62

119

116

97

57

74

72

116

74

 

P value

<0.001

/

/

/

0.534

<0.001

0.753

<0.001

0.761

0.524

0.923

0.261

0.744

/

I-square

88%

/

/

/

0.0%

79%

93%

0.0%

0.0%

0.0%

0.0%

66%

88%

/

Non-LVH

1.404

4.999a

  

0.354

0.973

 

-11.20

0.691

 

0.613

-0.635

/

/

Lower 95% CI

-1.908

3.286

/

/

0.165

-1.329

/

-160.8

-2.330

/

-5.161

-9.278 8.008

  

Upper 95% CI

4.717

6.711

  

0.544

3.274

 

138.4

3.713

 

6.388

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----

  

----

----

 

----

----

 

----

   

Number

217

217

  

121

121

 

310

121

 

224

121

  

P value

0.406

<0.001

/

/

<0.001

0.408

/

0.883

0.654

/

0.835

0.886

/

/

I-square

80%

0.0%

/

/

0.0%

0.0%

/

75%

0.0%

/

79%

91%

/

/

Left heart disease

-4.022

0.433

-0.966

-2.666

0.298

3.561

0.053

-149.7a

0.651

-0.951

0.079a

-1.352

-70.97

2.686

Lower 95% CI

-10.137 2.093

-6.49 7.357

-2.230 0.298

-7.145 1.814

0.134

1.786 5.335

-0.275

-352.4

-2.781 4.084

-4.377 2.474

-2.610 2.768

-3.932 1.227

-273.90

-2.635 8.008

Upper 95% CI

    

0.461

 

0.380

53.0

    

131.95

 

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----

----

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----

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----

----

----

----

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Number

306

262

98

99

165

286

116

389

229

252

419

360

173

100

P value

0.197

0.902

0.134

0.243

<0.001

<0.001

0.753

0.148

0.710

0.586

0.954

0.304

0.493

0.322

I-square

96%

94%

95%

90%

0.0%

84%

93%

84%

81%

75%

66%

75%

91%

99%

Subgroup/ Sensitivity a

LVMi g/m 2

EDVi ml/m 2

IVS Mm

VTD mm

Cardiac index L/min/m 2

EF%

E/A ratio

NTpro-BNP Pg/ml

HR bpm

MAP mmHg

SBP mmHg

DBP mmHg

SVRi dynes m 2 /sec cm -5

FMD%

Right heart disease

    

0.309

   

-2.700

  

0.867

  

Lower 95% CI

/

/

/

/

0.178

/

/

/

-4.554

/

/

-2.637 4.372

/

/

Upper 95% CI

    

0.439

   

-0.847

     

----

    

----

   

----

  

----

  

Number

    

355

   

347

  

30

  

P value

/

/

/

/

<0.001

/

/

/

0.004

/

/

0.628

/

/

I-square

/

/

/

/

0.0%

/

/

/

0.0%

/

/

0.0%

/

/

Non-cardiac disease

        

-0.109

 

0.107

0.073

 

3.953

Lower 95% CI

/

/

/

/

/

/

/

/

-2.723

/

-2.287

-1.515 1.660

/

1.240

Upper 95% CI

        

2.504

 

2.502

  

6.667

----

        

----

 

----

----

 

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Number

        

374

 

374

374

 

68

P value

/

/

/

/

/

/

/

/

0.935

/

0.930

0.928

/

0.004

I-square

/

/

/

/

/

/

/

/

0.0%

/

0.0%

0.0%

/

96%

Age <60 yrs

    

0.284

3.187

0.173a

  

1.940

-0.008

-0.292

-130.44

 

Lower 95% CI

    

0.163

-0.716

-0.150

  

-0.824

-2.023

-1.631 1.047

-234.44

/

Upper 95% CI

/

/

/

/

0.405

7.089

0.496

/

/

4.704

2.006

----

-26.43

 

----

    

----

----

----

  

----

----

513

----

 

Number

    

399

74

71

  

212

513

 

89

 

P value

/

/

/

/

0.000

0.110

0.295

/

/

0.196

0.993

0.669

0.014

/

I-square

/

/

/

/

0.0%

80%

90%

/

/

0.0%

0.0%

0.0%

0.0%

/

Age - 60 yrs

-2.683a

0.433

 

-2.666

0.354

2.582

 

-40.199a

-0.491

-2.349

0.663

-2.048

-57.48

3.558a

Lower 95% CI

-9.169

-6.49

/

-7.145 1.814

0.165

-1.074

/

-196.023

-3.826

-5.851

-2.067

-4.741 0.646

-349.32

0.306

Upper 95% CI

3.804

7.357

 

----

0.544

6.237

 

115.624

2.844

1.153

3.392

 

234.36

6.809

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Nymber

262

262

 

99

121

167

 

355

221

143

315

234

143

132

P value

0.418

0.902

/

0.243

<0.001

0.166

/

0.613

0.773

0.189

0.634

0.136

0.699

0.032

I-square

95%

94%

/

90%

0.0%

90%

/

72%

79%

83%

72.%

71%

94%

99%

Subgroup/ Sensitivity a

LVMi g/m 2

EDVi ml/m 2

IVS Mm

VTD mm

Cardiac index L/min/m 2

EF%

E/A ratio

NTpro-BNP Pg/ml

HR bpm

MAP mmHg

SBP mmHg

DBP mmHg

SVRi dynes m 2 /sec cm -5

FMD%

Sildenafil

-4.022

0.433

-0.966

-2.666

0.289a

3.561

0.053

-161.9

-0.943

-0.880a

0.248

-0.995

-70.9

2.7

Lower 95% CI

-10.137

-6.49

-2.230

-7.145 1.814

0.179

1.786

-0.275

-351.5

-2.959

-3.642

-2.138

-2.852 0.863

-273.9

-2.6

Upper 95% CI

2.093

7.357

0.298

 

0.399

5.335

0.380

27.6

1.073

1.882

2.634

 

131.9

8.0

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----

----

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Number

306

262

98

99

461

286

116

407

536

296

446

409

173

100

P value

0.197

0.902

0.134

0.243

<0.001

<0.001

0.753

0.094

0.359

0.532

0.839

0.294

0.493

0.322

I-square

96%

94%

95%

90%

0.0%

84%

93%

82%

0.0%

72%

60%

63%

91%

/

Tadalafil

        

-1.033

 

4.659

1.101

 

3.953

Lower 95% CI

        

-7.141

 

-2.529

 

/

1.240

Upper 95% CI

/

/

/

/

/

/

/

/

5.075

/

11.846

-4.717 6.920

 

6.667

---

        

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----

----

 

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Number

        

32

 

32

32

 

68

P value

/

/

/

/

/

/

/

/

0.740

/

0.204

0.711

/

0.004

I-square

/

/

/

/

/

/

/

/

0.0%

/

0.0%

0.0%

/

/

Vardenafil

        

-0.408

     

Lower 95% CI

        

-3.746

     

Upper 95% CI

/

/

/

/

/

/

/

/

2.931

/

/

/

/

/

---

        

----

     

Number

        

409

     

P value

/

/

/

/

/

/

/

/

0.811

/

/

/

/

/

I-square

/

/

/

/

/

/

/

/

0.0%

/

/

/

/

/

  1. aSensitivity analysis. CI: confidence interval; DBP: diastolic blood pressure; EDVi: end-diastolic volume index; EF: ejection fraction; E/A ratio: the ratio of the early (E) to late (A) ventricular filling velocities; FMD: flow mediated dilation; HR: heart rate; IVS: interventricular septum; LVH: left ventricular hypertrophy; LVMi: left ventricular mass index; MAP: mean arterial blood pressure; NTpro-BNP: N-terminal-pro brain natriuretic peptide; SBP: systolic blood pressure; SVRi: systemic vascular resistance index; VTD: ventricular transverse diameter; WMD: weighted mean difference. Bold indicates when “p” are statistically significant. Italics indicates non significant resluts.
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