Candidate gene-environment interactions in breast cancer

Table 1 Established risk factors assessed in GxE interaction studies

Established risk factor	Traviset al. [[3]]	Milneet al. [[4]]	Campaet al. [[6]]	Nickelset al. [[5]]	Barrdahlet al. [[7]]	Schoepset al. [[12]]
Age at menarche (years)	X	X	X	X	X	X
Age at first birth (years)	X	X		X^a	X
Parous (% and/or number of live births)	X	X	X	X^a	X	X
Breast fed (% in parous women)	X			X
Menopausal status (% post-menopausal)	X
Age at natural menopause (years)	X		X		X
Use of oral contraceptives (yes/no or duration)				X	X	X
Use of HRT (yes/no or duration)	X		X	X		X^b
Body Mass Index (kg/m²)	X	X	X	X	X	X^c
Height (m)	X		X	X	X	X
Alcohol consumption (g per day)	X		X	X	X	X
Smoking (pack-years)			X	X	X
Family history of BC			X		X	X
Physical activity (hours per week)				X

^aThe ten established risk factors reported by Nickels et al. (Table 2) counts parity and age at first live birth as a single factor; ^bthe 10 established risk factors reported by Schoeps et al. (Table 2) counts combined estrogen-progesterone and estrogen only post-menopausal hormone therapy as two factors; ^cbody mass index in pre- and post-menopausal women as two factors. BC, breast cancer; HRT, hormone replacement therapy.

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