Skip to main content

Table 2 Details of GxE interaction studies comprising at least 5,000 cases and 5,000 controls

From: Candidate gene-environment interactions in breast cancer

Reference Study SNPs ERFs Cases Controls Strongest interaction Interaction effect size UnadjustedP
Travis et al. [3] Million women 12 10 7,610 10,196 CASP8-rs1045485; alcohol consumptiona 1.24 0.003
Milne et al. [4] BCAC (1) 12 4 26,349 32,208 LSP1- rs3817198; parity 1.05 0.002
Campa et al. [6] BPC3 (1) 17 9 8,576 11,892 5p12-rs10941679; use of estrogen only HRT 1.22 0.0072
Nickels et al. [5] BCAC (2) 23 10 34,793 41,099 LSP1- rs3817198; parity 1.06 2.4 × 10-6
1p11.2-rs11249433; ever parous 1.16 5.3 × 10-5
CASP8-rs17468277; alcohol consumptiona 1.59 3.1 × 10-4
Barrdahl et al. [7] BPC3 (2) 39 10 16,285 19,376 6q25-rs2046210; alcohol consumptiona 1.11 0.002
Schoeps et al. [12] BCAC 71,527 10 34,475 34,786 21q22.12-rs10483028 and rs2242714; postmenopausal BMI 0.84 3.2 × 10-5
  1. aAlcohol consumption was defined as per additional 10 g in Travis et al. and Barrdahl et al. and as < or ≥20 g/per day by Nickels et al. BCAC, Breast Cancer Association Consortium; BMI, body mass index; BPC3, Breast and Prostate Cancer Cohort Consortium; ERFs, established risk factors for breast cancer; HRT, hormone replacement therapy.