Candidate gene-environment interactions in breast cancer

Table 2 Details of GxE interaction studies comprising at least 5,000 cases and 5,000 controls

Reference	Study	SNPs	ERFs	Cases	Controls	Strongest interaction	Interaction effect size	UnadjustedP
Travis et al. [3]	Million women	12	10	7,610	10,196	CASP8-rs1045485; alcohol consumption^a	1.24	0.003
Milne et al. [4]	BCAC (1)	12	4	26,349	32,208	LSP1- rs3817198; parity	1.05	0.002
Campa et al. [6]	BPC3 (1)	17	9	8,576	11,892	5p12-rs10941679; use of estrogen only HRT	1.22	0.0072
Nickels et al. [5]	BCAC (2)	23	10	34,793	41,099	LSP1- rs3817198; parity	1.06	2.4 × 10^-6
						1p11.2-rs11249433; ever parous	1.16	5.3 × 10^-5
						CASP8-rs17468277; alcohol consumption^a	1.59	3.1 × 10^-4
Barrdahl et al. [7]	BPC3 (2)	39	10	16,285	19,376	6q25-rs2046210; alcohol consumption^a	1.11	0.002
Schoeps et al. [12]	BCAC	71,527	10	34,475	34,786	21q22.12-rs10483028 and rs2242714; postmenopausal BMI	0.84	3.2 × 10^-5

^aAlcohol consumption was defined as per additional 10 g in Travis et al. and Barrdahl et al. and as < or ≥20 g/per day by Nickels et al. BCAC, Breast Cancer Association Consortium; BMI, body mass index; BPC3, Breast and Prostate Cancer Cohort Consortium; ERFs, established risk factors for breast cancer; HRT, hormone replacement therapy.

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