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Figure 4 | BMC Medicine

Figure 4

From: Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis

Figure 4

Comparison of DHT levels after testosterone treatment with DHT levels that are associated with cardiovascular disease risk. Left panel. Testosterone-induced elevation of DHT in the eight RCTs of testosterone injection, twenty RCTs of transdermal administration and four RCTs of oral testosterone administration shown in Table 2. Transdermal administration causes a greater elevation of serum DHT. Center panel. Data from panel 1 is overlayed on observational data from Shores et al. showing the relationship between serum DHT and 10 year risk of incident ischemic stroke in older men. The solid line represents the estimated hazard ratio (HR) and the shaded area depicts the 95% confidence interval. All models are adjusted for age (reprinted with permission from Shores et al. Clin Endocrinol (Oxf) 2014. doi: 10.1111/cen.12452 [22]. Right panel. Data from panel 1 is overlayed on observational data from Shores et al. showing the relationship between serum DHT and incident cardiovascular disease risk. The solid line represents the estimated hazard ratio (HR) and the shaded area depicts the 95% confidence intervals. All models are adjusted for age. (Reprinted with permission from Shores et al. J Clin Endocrinol Metab 2014, 99:2061-2068. [23]). DHT, dihydrotestosterone; RCT, randomized controlled trial.

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