Figure 4

Epidemiologic and economic impact of sustained active case finding over 10 years. Panels A-C (top row) shows projected incidence (green) and mortality (red) in communities with a sustained active case finding intervention capable of increasing the cases detected in the first year by 25% of the counterfactual scenario (solid line) and a counterfactual scenario with no intervention (dashed line). Panels D-F (second row) shows the corresponding cost-effectiveness of the intervention as a function of the cost per case detected in year 1 (y-axis) and the time horizon over which costs and effects are considered (x-axis, Note: the time horizon here is equal to the duration of the intervention in this sustained setting). Contour lines are labeled in these plots as the cost per DALY averted, with “highly cost-effective” corresponding to a country’s per-capita GDP.