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Table 2 Previous studies of intratympanic dexamethasone therapy as a salvage treatment

From: A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment

 

No. of patients

PTA recovery

Dexamethasone concentration

Doses

Proportion of recovery (%)

Ho et al. [9]

15

28 dB

4 mg/mL

3 doses, once a week

53%

Choung et al. [10]

34

9 dB

5 mg/mL

4 doses, twice a week

39%

Roebuck et al. [11]

31

12 dB

24 mg/mL

Single

29%

Haynes et al. [12]

40

5 dB

24 mg/mL

Single

27.5%

Plontke et al. [13]

11

14 dB

4 mg/mL

Pump for 14 days

45%

Kakehata et al. [14]

24

17 dB

4 mg/mL

15 doses

58%

Lee et al. [15]

34

NA

4 mg/mL

6 doses for 14 days

21%

Mean (95% CI)

27 (21-33)

   

39% (30%-48%)

  1. PTA, Pure-tone audiometry; NA, Not available; CI, Confidential interval.