Figure 4From: Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: a seven case series Histological sample from the tibia of patient #1. (A) H&E. Bony trabeculae separated by fibrosis and sheets of foamy macrophages. (B) Histiocytes demonstrating intense granular staining for CD68. (C) Histiocytes demonstrating patchy staining for factor XIIIa. (D) S-100 protein staining of the biopsy specimen.Back to article page