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Figure 6 | BMC Medicine

Figure 6

From: Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: a seven case series

Figure 6

Cerebellar MRI findings of patients #1, #2 and #4 Axial T2 weighted MR images of patient #1 at the level of the cerebellum, middle cerebellar peduncles and pons taken at the time of diagnosis (A) one year following diagnosis (B) and four years following diagnosis (C). Note the bilateral hyperintense signals which emerged one year following diagnosis in the pons and peri-dentate regions as well as in the left middle cerebellar peduncle (B). The signal intensity of these processes seems to have decreased during the following three years (C). (D) An axial T2 weighted MR image of patient #2 at the level of the cerebellum demonstrating a unilateral focus of hypointense signal at the left peri-dentate region. (E) This cluster like lesion is better accentuated in SWI sequence. (F) An axial T2 weighted MR image of patient #4 displaying multiple, bilateral, diffuse foci of hyperintense signals involving the brainstem and peridentate areas. Another abnormal finding, adherent to the dura of Meckel’s cave, exhibits radiological similarity to a meningioma. Note the variable MR manifestations of cerebellar lesions in different ECD patients. ECD, Erdheim Chester disease; MR, magnetic resonance; SWI, susceptibility weighted imaging.

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