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Table 1 Characteristics of included guidelines and consensus statements

From: Diagnosis and treatment of hyponatremia: a systematic review of clinical practice guidelines and consensus statements

Developer Year Country Funding source Target population Target users Guideline writers Guideline review Guideline update Methods support Evidence base
NIV 2012 Netherlands Government funding Adults with hyponatremia Clinicians, Internists Multidisciplinary internists, epidemiologist Dutch Association of Internists (NIV), expert peer review In case of breakthrough changes in diagnosis or treatment PROVA – company specialized in Evidence Based Guideline Development Systematic literature review
NHS 2011 UK NS Adults with hyponatremia in primary care Primary care professionals within NHS NS NS Planned in 2015 NS Systematic literature review
GAIN* 2010 Northern Ireland Government funding Adults with hyponatremia NS Multidisciplinary anesthetists, clinical chemist, nephrologist NS 3 years NS NS
AEEH* 2003-2004 Spain NS Patients with cirrhosis NS Gastroenterologists NS NS NS NS
EHN* 2013 Spain NS Hospitalized patients with SIADH NS Multidisciplinary endocrinologists, nephrologists, internists, hospital pharmacist NS NS NS Consensus statements
ERBP/ESE/ESICM 2014 Europe Unrestricted grant from participating societies Adults with hyponatremia Health care professionals dealing with hyponatremia Multidisciplinary nephrologists, endocrinologists, general internists, critical care physicians External review by KHA-CARI, ESA, and members ERA-EDTA 5 years or earlier in case of new evidence requiring changes ERBP methods support team Systematic literature review
North America           
UF 2008-2009 USA NS Neurosurgery patients with hyponatremia NS Multidisciplinary neurosurgeons, nurse practitioners, nephrologists, critical care physician, endocrinologist, pharmacist, nurses NS NS NS Systematic literature review
HEP 2013 USA Funding Unrestricted educational grant from pharmaceutical company Patients with hyponatremia NS Endocrinologist, nephrologists NS NS NS Systematic literature review
RCHM* 2012 Australia NS Children NS NS External review within the hospital where appropriate’ 12 to 24 months NS NS
EAH- ICD* 2007 USA, Canada, UK, Switzer-land, Canada, South Africa, New Zealand, Australia No commercial sponsorship’ People with exercise-associated hyponatremia Medical personnel, athletes, greater public Multidisciplinary endocrinologist, epidemiologist, nephrologists, emergency medicine physician, general practitioner, internist, sports physicians, exercise physiologists NS NS NS Systematic literature review
  1. NIV, Nederlandse Internisten Vereniging [16]; NHS, National Health Service [17]; GAIN, Guidelines and Audit Implementation Network [22]; AEEH, La Asociación Española para el Estudio del Hígado [23]; EHN, European Hyponatremia Network [25]; ERBP, European Renal Best Practice; ESE, European Society of Endocrinology; ESICM, European Society of Intensive Care Medicine [20]; UF, University of Florida [18]; HEP, Hyponatremia Expert Panel [19]; RCH Melbourne, the Royal Children’s Hospital Melbourne [21]; EAH-ICD, International Exercise-Associated Hyponatremia Consensus Development Conference [24]; [Na], Serum sodium concentration; NS, Not stated; KHA-CARI, Kidney Health Australia, Caring for Australasians with Renal Impairment; ESA, Endocrine Society of Australia; ERA-EDTA, European Renal Association; European Dialysis and Transplant Association; *Classified as consensus statement.