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Figure 3 | BMC Medicine

Figure 3

From: DNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma

Figure 3

PAM diagnostic panel model for renal cell carcinoma. (A) ROC curve of best 5 CpG model (Benjamini and Hochberg-adjusted P = 8.10 × 10-31) from PAM diagnostic panel produced via the HudsonAlpha/Stanford data (ROC AUC = 0.991), and applied to the TCGA data (ROC AUC = 0.990). (B) ROC curve of best 5 CpG model applied to TCGA ccRCC and normal kidney tissue data (ROC AUC = 0.98). (C) ROC curve of best 5 CpG model applied to TCGA pRCC and normal kidney tissue data (ROC AUC = 0.97). (D) ROC curve of best 5 CpG model applied to TCGA chRCC and normal kidney tissue data (ROC AUC = 0.99). Random model is 50 random draws of 5 non-significant training set CpGs.

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