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Table 3 Comparison of the main causes of disability-adjusted life years (DALYs) and years lived with disability (YLDs), in 1990 and 2010, for the Spanish population

From: The burden of disease in Spain: results from the global burden of disease study 2010

YLDs (hundreds)

DALYs (hundreds)

 

1990

2010

% Δ

1990

2010

% Δ

All causes

44,316.8

55,706.6

25.7%

104,615.9

110,269.4

5.4%

Communicable, maternal, neonatal, and nutritional disorders

1,914.7 (1,415.3–2,628.9)

1,942.5 (1,377.8–2,767.8)

1%

6,394.8 (5,773.6–7,126)

5,067.4 (4,450.8–5,848.2)

−21%

HIV/AIDS and tuberculosis

285.4 (202.5–384.5)

183 (128.5–248.3)

−36%

1,532.1 (1,356.2–1,720.5)

738.3 (643.6–844.3)

−52%

  Tuberculosis

114.8 (71.7–171.8)

84.4 (50.8–129.2)

−26%

340.6 (274–409.3)

175.9 (136.8–230.7)

−48%

  HIV/AIDS

170.6 (123.2–223.1)

98.6 (70.8–131.4)

−42%

1,191.6 (1,042–1,360.4)

562.4 (478.8–651.9)

−53%

  HIV disease resulting in mycobacterial infection

12.1 (6.7–19.4)

4.7 (2–8.3)

−62%

59.8 (51.5–69.1)

19.6 (16–24.1)

−67%

  HIV disease resulting in other specified or unspecified diseases

158.4 (114.2–206.7)

93.9 (67.9–125.4)

−41%

1,131.7 (993.6–1,271.3)

542.8 (469.8–629.4)

−52%

Diarrhea, lower respiratory infections, meningitis, and other common infectious diseases

858.5 (590.7–1249)

925.1 (621.7–1339.5)

8%

2,555.5 (2,206.4–3,004.8)

2,358.1 (1,992.4–2,814.4)

−8%

  Diarrheal diseases

306.2 (201.3–440.4)

363.2 (238.6–520.2)

19%

358.6 (252.5–493.1)

428.9 (305.6–585.7)

20%

  Typhoid and paratyphoid fevers

0 (0–0.1)

0 (0–0.1)

27%

1.1 (0.1–2)

1 (0.1–2)

−4%

  Lower respiratory infections

44.3 (29.7–62)

48.4 (33–66.8)

9%

1391.6 (1227.5–1612.5)

1,275.9 (1,096–1,523.9)

−8%

  Upper respiratory infections

219.3 (106.2–390.9)

227.8 (110.9–429.7)

4%

221 (107.8–392.7)

228.4 (111.5–430.3)

3%

  Otitis media

211.6 (127.1–339.9)

211.9 (120.7–361)

0.2%

213.6 (127.9–341.7)

213.3 (123–363.3)

0%

  Meningitis

52.1 (33.7–77.9)

46.8 (29–71.8)

−10%

261.9 (229.8–309)

153.7 (129.1–183.3)

−41%

  Pneumococcal meningitis

10.2 (6.2–15.4)

6.7 (3.8–10.6)

−34%

39.8 (33.2–47.3)

21.8 (17.6–26.7)

−45%

  H influenza type B meningitis

7.4 (4.3–11.8)

3.1 (1.6–5.1)

−58%

33.7 (27.2–42.1)

13.6 (10.8–17.3)

−60%

  Meningococcal infection

16.6 (10.2–25.7)

14.6 (8.4–23.2)

−12%

88.8 (75.5–106.7)

50.1 (40.9–61.3)

−44%

  Other meningitis

17.2 (10.9–26.6)

21.8 (13.3–33.6)

27%

99 (86–116.3)

67.7 (55.6–82.7)

−32%

  Encephalitis

5.6 (3.3–8.7)

5.5 (3.2–9)

−1%

28.5 (24.7–32.7)

17.9 (14.7–21.8)

−37%

  Diphtheria

0 (0–0)

0 (0–0)

−82%

0.9 (0–7.3)

0.3 (0–2.5)

−66%

  Whooping cough

2.4 (1.3–3.8)

0.6 (0.3–1.1)

−74%

47.8 (2.3–221.4)

9.3 (0.6–40.9)

−81%

  Tetanus

0 (0–0)

0 (0–0)

−69%

3.4 (0.4–13)

0.7 (0.1–2.6)

−80%

  Measles

0.8 (0.3–1.4)

0 (0–0.1)

−99%

4 (2.2–6.4)

1.5 (0.7–3.9)

−62%

  Varicella

16.2 (8.2–29.1)

20.8 (10.1–39.2)

29%

23.3 (9.2–63.2)

27.3 (11.6–67.5)

18%

Neglected tropical diseases and malaria

8.5 (2.3–21.8)

15.6 (2.5–51.2)

83%

69.6 (39.7–120.3)

64.9 (35.1–120.1)

−7%

  Malaria

0.5 (0–3.9)

0.1 (0–0.8)

−75%

0.5 (0–3.9)

0.1 (0–0.8)

−75%

  Leishmaniasis

1.3 (0.6–2.7)

1.4 (0.6–2.9)

6%

10.6 (7.4–14.7)

8.4 (5.8–11.5)

−21%

  *Cysticercosis

0 (0–0)

–*

–*

0.6 (0–2.2)

–*

–*

  Echinococcosis

5.3 (0.8–18.1)

7 (1–25.6)

32%

15.6 (2.2–47.7)

12.1 (2.1–35.5)

−22%

  Dengue

0 (0–0)

0 (0–0)

–*

31.8 (9.6–70.5)

30.9 (12.5–68.8)

−3%

  Rabies

0 (0–0)

0 (0–0)

13%

5.6 (2.7–12.4)

2 (1.1–3.9)

−64%

  Food-borne trematodiases

0.1 (0–0.4)

0.1 (0–0.3)

−31%

0.1 (0–0.4)

0.1 (0–0.3)

−31%

  Other neglected tropical diseases

1.3 (0.1–1.6)

7 (0.2–6.2)

425%

4.8 (2.5–7)

11.3 (3–11.7)

133%

Maternal disorders

14.1 (8.9–21.7)

12.5 (7.5–19.6)

−11%

37 (29–47.5)

28.7 (21.7–37.2)

−22%

  Maternal hemorrhage

5.9 (3.4–9.5)

5.3 (3–8.5)

−11%

10.3 (7.4–14)

8.5 (6–11.9)

−17%

  Maternal sepsis

0.3 (0–1)

0.3 (0–1)

−9%

1.3 (0.8–2.1)

0.9 (0.5–1.6)

−33%

  Hypertensive disorders of pregnancy

0.6 (0.3–1.1)

0.7 (0.3–1.2)

9%

3.9 (3–5.1)

2.9 (2.1–3.8)

−26%

  Obstructed labor

1.1 (0–3.4)

1.1 (0–3.4)

−2%

2 (0.9–4.3)

1.8 (0.7–4.2)

−12%

  Abortion

2 (1.1–3.4)

1.4 (0.7–2.5)

−29%

5.2 (3.9–6.8)

3.4 (2.4–4.6)

−35%

  Other maternal disorders

4.1 (2.6–6.2)

3.8 (2.3–5.8)

−8%

14.2 (11.1–18.1)

11.3 (8.4–14.4)

−21%

Neonatal disorders

224.6 (164.9–300.8)

218.4 (162.3–282.8)

−3%

1,468.3 (1,242.3–1,668.6)

1,061.2 (934.7–1,183)

−28%

  Preterm birth complications

96.4 (66.9–136.9)

109.4 (75.9–149.6)

13%

788.4 (627.9–938.5)

533 (433–665.9)

−32%

  Neonatal encephalopathy (birth asphyxia and birth trauma)

126.6 (89.5–172.7)

107 (77.3–143.6)

−15%

425.4 (336.5–527.3)

297.5 (235.6–375)

−30%

  Sepsis and other infectious disorders of the newborn baby

0.1 (0.1–0.3)

0.3 (0.2–0.6)

140%

110.1 (60.9–192.3)

111.2 (60–197.5)

1%

  Other neonatal disorders

1.4 (1–2)

1.7 (1.2–2.3)

16%

144.3 (91.2–262.3)

119.5 (67.1–179.2)

−17%

Nutritional deficiencies

444.6 (269.2–712.5)

507.8 (314.2–801.1)

14%

524.2 (347–797.2)

590.7 (394.4–885)

13%

  Protein-energy malnutrition

14.3 (9.3–21.2)

22.7 (14.8–31.8)

59%

46.2 (38.5–57.6)

75 (52.4–93.8)

62%

  Iodine deficiency

427.1 (251.8–694)

480.5 (285–763.7)

13%

428.8 (253.7–695.7)

482.4 (286.9–765.8)

13%

  Iron-deficiency anemia

1.1 (0.5–2)

3 (1–3.2)

171%

41.8 (35.4–54.5)

27.9 (16.9–33.7)

−33%

  Other nutritional deficiencies

2.2 (1.8–2.8)

1.5 (0.9–2)

−29%

7.5 (6.3–9.8)

5.3 (3.2–6.9)

−29%

Other communicable, maternal, neonatal, and nutritional disorders

79 (38.7–149.3)

80.1 (35.6–168.3)

1%

208 (161.6–281.2)

225.5 (162.4–323.7)

8%

  Sexually transmitted diseases excluding HIV

64.3 (29.6–128.4)

56.9 (26–114)

−11%

91.6 (56.3–157.8)

66.6 (35.2–123.7)

−27%

  Syphilis

3.9 (0.2–8.7)

4.8 (0.3–10.7)

21%

25.4 (15.7–39.3)

10.9 (5–18)

−57%

  Sexually transmitted chlamydial diseases

25.3 (8.7–60)

22.4 (7.6–53.6)

−12%

26.7 (10.1–61.5)

23.2 (8.3–54.3)

−13%

  Gonococcal infection

13.7 (5.2–30.2)

14.5 (5–32.7)

6%

14.8 (6.1–31.3)

15.1 (5.6–33.5)

2%

  Trichomoniasis

13.3 (0.1–41.8)

9.2 (0.1–29.1)

−31%

13.3 (0.1–41.8)

9.2 (0.1–29.1)

−31%

  Other sexually transmitted diseases

8 (2.9–18.1)

6 (2.5–12)

−25%

11.5 (6.2–21.5)

8.2 (4.5–14.2)

−29%

  Hepatitis

12.2 (6–21.9)

12.9 (6.2–22.8)

6%

67.3 (57.9–79)

66 (55.8–77.8)

−2%

  Acute hepatitis A

8.3 (3.9–14.7)

7.5 (3.7–13)

−9%

17 (11.2–24.8)

11 (6.5–17.6)

−35%

  Acute hepatitis B

2.8 (0.2–9.2)

3.4 (0.2–10.6)

21%

42.8 (26.3–55.3)

24 (12.6–43.4)

−44%

  Acute hepatitis C

1 (0.2–2.1)

2 (0.4–4.1)

87%

7.6 (2.8–15.8)

31 (10.5–53.4)

308%

  Leprosy

0.1 (0–0.1)

0 (0–0)

−87%

0.1 (0–0.1)

0 (0–0)

−87%

  Other infectious diseases

2.5 (0–0.3)

10.3 (0–0.4)

314%

49 (37.6–81.3)

92.8 (39.3–114.7)

89%

Non-communicable diseases

38,528.9 (32,278.2–45,503.6)

48,269.1 (40,257.6–56,616.6)

25%

86,260 (79,823.1–93,301.2)

95,239.4 (87,522.2–10,3475.6)

10%

Neoplasms

474.2 (349.1–630.6)

816.4 (597.6–1074.5)

72%

16,917.3 (16,102.7–17,858.3)

19,304.5 (18,003–20,302.6)

14%

  Esophageal cancer

3.2 (1.6–5.3)

3.6 (1.8–6.2)

10%

413.9 (310.3–535.2)

392.1 (290.6–538.8)

−5%

  Stomach cancer

24.3 (15.3–35.6)

21.2 (12.9–33)

−13%

1,443.2 (1,131–1,931.8)

1,007.9 (765–1,402.6)

−30%

  Liver cancer

6.5 (3.9–9.8)

9.6 (5.8–14.8)

47%

720 (581.5–818.5)

846.8 (712.5–1,044.6)

18%

  Liver cancer secondary to hepatitis B

0.9 (0.3–1.8)

1.3 (0.4–2.4)

38%

100.9 (80.1–116.3)

119.2 (97.8–152.4)

18%

  Liver cancer secondary to hepatitis C

2.8 (1.5–4.7)

3.9 (2–6.6)

40%

287.9 (236.3–332.2)

331.9 (277.3–427.1)

15%

  Liver cancer secondary to alcohol use

2.2 (1.1–3.7)

3.6 (1.9–5.9)

64%

253 (201.7–291.3)

301 (253–381)

19%

  Other liver cancer

0.6 (0.1–1.4)

0.8 (0.1–1.6)

26%

78.2 (62.9–90.4)

94.7 (74.6–116.3)

21%

  Larynx cancer

14 (7.3–24.9)

12.3 (6.5–23.3)

−12%

498.7 (252.2–859.6)

373.9 (202.3–685.2)

−25%

  Trachea, bronchus, and lung cancers

34.1 (22.3–49.5)

45.5 (25.9–64.2)

34%

3,138.8 (2,541.8–3,982.3)

3,686.7 (2,408.1–4,161.1)

17%

  Breast cancer

122.7 (80.8–187.9)

188.1 (120.8–277.2)

53%

1,496.8 (1,400.8–1,611.5)

1,469.4 (1,340.6–1,619.2)

−2%

  Cervical cancer

5.4 (2.9–8.7)

5.2 (2.7–8.6)

−4%

226.8 (143.3–321.6)

212.3 (135.6–306.1)

−6%

  Uterine cancer

10.9 (5.7–20.1)

13.6 (5.7–23.1)

24%

174.1 (100.8–316.1)

194.6 (93.5–271.9)

12%

  Prostate cancer

40.2 (27–60)

120.3 (78.9–185.9)

199%

609 (373.5–941.4)

939.3 (572.7–1,489.8)

54%

  Colon and rectum cancers

63.1 (44.8–85.4)

128.7 (90.3–171.7)

104%

1,675.7 (1,476.6–1,895.5)

2,452.4 (2,019.5–2,711)

46%

  Mouth cancer

12.4 (8.2–17.8)

13.8 (8.9–20.3)

12%

307.3 (257.8–337.4)

296.6 (250.1–367.2)

−3%

  Nasopharynx cancer

0.9 (0.3–1.9)

1 (0.3–2)

5%

70.2 (40.1–94.4)

63.2 (40.4–88.2)

−10%

  Cancer of other part of pharynx and oropharynx

4.1 (2–7)

5.8 (2.8–9.4)

42%

172.5 (100.3–251.3)

211.9 (125.8–299.5)

23%

  Gallbladder and biliary tract cancer

3.6 (1.9–6.1)

5.1 (2.5–9)

41%

253.9 (169.6–370.5)

274.3 (193–414.1)

8%

  Pancreatic cancer

3.9 (2–6.5)

6.3 (3.4–10.4)

63%

627.8 (480.8–812.9)

881.8 (646.5–1120.7)

40%

  Malignant melanoma of skin

4.2 (2.3–7.9)

8.6 (4.7–13.7)

103%

140.1 (94.4–223.2)

207.1 (133–294.9)

48%

  Non-melanoma skin cancer

15.6 (10.7–21.9)

38 (25.9–52.8)

143%

89.4 (55.1–125.3)

110.9 (80.5–165.1)

24%

  Ovarian cancer

6.2 (3.6–9.8)

9.4 (5.2–14.5)

52%

336.7 (252.6–453.1)

425.2 (287.4–561.8)

26%

  Testicular cancer

0.8 (0.2–1.6)

1.4 (0.5–2.9)

86%

22.9 (13.7–34.8)

22.7 (12.9–32.9)

−1%

  Kidney and other urinary organ cancers

5.6 (3.1–8.6)

17.7 (10.2–30.6)

218%

255.5 (178.9–327.2)

592.6 (435.2–958.7)

132%

  Bladder cancer

31.7 (21.7–43.9)

49.8 (32.2–69.6)

57%

617 (491.5–789.2)

704.1 (508.2–824.7)

14%

  Brain and nervous system cancers

11.5 (6.6–17.9)

17.4 (8.7–27.2)

51%

716.6 (488.1–1,011.1)

848.3 (492.4–1,050.7)

18%

  Thyroid cancer

2.5 (1.3–4.4)

4.1 (2.2–6.8)

63%

51.9 (40.5–66.8)

61.5 (45.7–78.9)

18%

  Hodgkin’s disease

2.4 (1–4.2)

2.1 (0.9–3.9)

−11%

112.8 (73.1–166.8)

72.3 (47.9–109.7)

−36%

  Non-Hodgkin’s lymphoma

9.4 (6–13.8)

16.1 (10–23.9)

72%

417.3 (366.4–493.7)

503.5 (364.3–578.3)

21%

  Multiple myeloma

5.4 (2.8–9)

8.3 (4.3–13.5)

55%

212.7 (146.8–305.2)

275.6 (182.9–388.8)

30%

  Leukemia

10.4 (6.7–15.4)

16.1 (10–23.5)

55%

705.9 (575.5–880)

688.4 (544.1–817)

−2%

  Other neoplasms

19.2 (12.4–28.5)

47.2 (30–69.8)

145%

1,409.8 (1,108.1–1,845.1)

1,489.3 (1,190.5–2,016.9)

6%

Cardiovascular and circulatory diseases

1,911.6 (1,475.9–2,423)

2,864.9 (2,268.9–3,499.4)

50%

20,076.7 (18,998.5–20,904.2)

17,802 (16,834.2–19,181.8)

−11%

  Rheumatic heart disease

125.4 (77.4–198.2)

139.1 (93.2–207.5)

11%

823.4 (745.2–933.8)

507.3 (429.5–599)

−38%

  Ischemic heart disease

737.6 (477.9–1108)

974.8 (636–1420.7)

32%

9,202.7 (8,705.1–9,952.4)

8,055.8 (7,462.7–8,876.3)

−12%

  Cerebrovascular disease

337.1 (278.1–393.5)

640.5 (529.3–755.2)

90%

6,437.3 (5,648.1–6,783.7)

4,752.8 (4,252.9–5,829.1)

−26%

  Ischemic stroke

271.4 (225–318.7)

515.9 (426.9–609.4)

90%

4,130.9 (3,546.5–4,389.3)

3,011 (2,635.2–4,183.6)

−27%

  Hemorrhagic and other non-ischemic stroke

65.6 (54.3–77.7)

124.6 (102.1–147.8)

90%

2,306.5 (2,058.8–2,601.6)

1,741.8 (1,502.3–1,936)

−24%

  Hypertensive heart disease

28.3 (17.3–42.8)

46.5 (28.8–71.4)

65%

531.9 (432.3–671.4)

613 (490.4–764.1)

15%

  Cardiomyopathy and myocarditis

17.5 (10.3–27.4)

26.6 (16.3–40.9)

52%

537.7 (496.6–569.2)

723.9 (634–857.1)

35%

  Atrial fibrillation and flutter

278.3 (186.1–398)

460.9 (306.5–658)

66%

363.2 (269.6–484.1)

849.2 (631.8–1127.7)

134%

  Aortic aneurysm

0 (0–0)

0 (0–0)

–*

261.2 (199.7–339.1)

308.2 (224.6–403.1)

18%

  Peripheral vascular disease

39.5 (20.1–70.8)

60.7 (30.8–109.7)

54%

83.5 (54.6–124.9)

174.6 (116.3–253.8)

109%

  Endocarditis

4.2 (2.4–6.8)

7.4 (4.5–11.6)

75%

74.6 (64–86.9)

76.3 (59.9–88)

2%

  Other cardiovascular and circulatory diseases

343.8 (182.1–561.1)

508.7 (275.7–807.5)

48%

1,761.1 (1,592.8–1,992.2)

1,740.9 (1,496.8–2,046.5)

−1%

Chronic respiratory diseases

1,935.1 (1,247–2,764.6)

22,17.7 (14,39.4–31,23.6)

15%

5,623.2 (4,907.3–6,436.1)

5,260.3 (4,434.9–6,184.9)

−6%

  Chronic obstructive pulmonary disease

860.7 (5,23.1–1,276.8)

10,99.1 (683–15,94.7)

28%

3,030.1 (2,586.4–3,515.9)

2,916 (2,423.7–3,483.1)

−4%

  Pneumoconiosis

8.3 (5.3–12)

15.9 (10–23.7)

92%

195.7 (134.5–283)

158.8 (112.5–223.2)

−19%

  Asthma

749.4 (411.4–1,203.2)

791.4 (443–1,253.1)

6%

969.4 (632.4–1423.6)

917.8 (564.5–1377.3)

−5%

  Interstitial lung disease and pulmonary sarcoidosis

8.9 (5.9–13.3)

16.1 (10.4–24.3)

81%

158.8 (118.1–251.5)

262.6 (181.8–373)

65%

  Other chronic respiratory diseases

307.9 (187–458.9)

295.2 (183.7–431.1)

−4%

1,269.2 (988–1,483.8)

1,005.2 (819.7–1,264)

−21%

Cirrhosis of the liver

34.4 (21.9–49.6)

37.6 (24.3–54)

9%

2,358.1 (1,931.4–2,609.8)

1,772.7 (1585.9–2,231.2)

−25%

  Cirrhosis of the liver secondary to hepatitis B

1.3 (0.5–2.5)

1.3 (0.5–2.6)

4%

89.4 (70.2–105.5)

67.9 (57–86.1)

−24%

  Cirrhosis of the liver secondary to hepatitis C

13.2 (7.4–21.5)

14.4 (7.7–23.3)

9%

895 (711.6–1049.2)

687.1 (582–870.4)

−23%

  Cirrhosis of the liver secondary to alcohol use

15.8 (8.9–25)

17.5 (9.9–28.4)

11%

1,105.7 (847.2–1295.5)

830.5 (694.9–1,084.7)

−25%

  Other cirrhosis of the liver

4.1 (2–6.9)

4.3 (2.1–7.6)

4%

268 (211.1–313.4)

187.2 (156.9–238.2)

−30%

Digestive diseases (except cirrhosis)

423.2 (248.1–730.7)

492.4 (313.7–755.8)

16%

1,683 (1,452.6–2,012.8)

1,860 (1,610.1–2,164.5)

11%

  Peptic ulcer disease

34 (17.9–64.8)

21.8 (11–46.2)

−36%

251.8 (202.3–293.9)

116.2 (95–164.7)

−54%

  Gastritis and duodenitis

29.9 (19.3–44.6)

38.8 (25.8–56.3)

30%

46.9 (33.4–62.6)

46.5 (32.1–65)

−1%

  Appendicitis

7.8 (2.8–16.7)

8.3 (3–17.8)

6%

43.7 (30.9–65.7)

37.7 (22.8–52.5)

−14%  

  Paralytic ileus and intestinal obstruction without hernia

0.6 (0–2.7)

0.6 (0–2.6)

3%

123.3 (96.4–175.4)

169.4 (106.6–226.9)

37%

  Inguinal or femoral hernia

28.3 (6.6–84)

28.9 (5.7–81.8)

2%

55.8 (33.9–110.3)

48.7 (25.4–101.4)

−13%

  Non-infective inflammatory bowel disease

205.8 (88.9–434.4)

214.3 (109.5–390.4)

4%

243.3 (127.2–473.9)

257 (151.9–435.7)

6%

  Vascular disorders of intestine

1 (0.2–2.4)

1.6 (0.3–3.9)

70%

232.9 (117.1–468.5)

313.5 (166–604)

35%

  Gall bladder and bile duct disease

36.4 (24.5–51.6)

45.6 (30.7–64.3)

25%

189.2 (161.3–229.6)

207.8 (164.8–260.5)

10%

  Pancreatitis

16.3 (5.8–38.3)

37.2 (12.8–83.9)

128%

224.4 (164.8–275.8)

228.1 (177–303.9)

2%

  Other digestive diseases

63.2 (37–108.4)

95.3 (60.6–146.9)

51%

271.7 (228–356.4)

435.1 (337.6–529.1)

60%

Neurological disorders

3,407 (2,631.9–4,321.9)

4,627.9 (3,616.3–5,804.5)

36%

4,581 (3,789.1–5,481.9)

7,372.4 (6,127.5–8,666.4)

61%

  Alzheimer's disease and other dementias

858.3 (612.7–1,136)

1,640.7 (1,185–2,196.8)

91%

1,433.9 (1,138.4–1,754.3)

3,518 (,2707.8–4,334.5)

145%

  Parkinson's disease

71.8 (46–114.3)

115.7 (72.9–189)

61%

230.4 (180.8–300.8)

390 (290.8–496.1)

69%

  Epilepsy

292 (215.3–381.1)

324 (242.9–425.2)

11%

399.4 (320.1–491.9)

432.1 (343–538.1)

8%

  Multiple sclerosis

37.7 (26.5–51)

54.5 (37.3–74.1)

45%

82.1 (67.6–98.9)

109 (86.3–133.8)

33%

  Migraine

1,893.5 (1,198.1–2,731.1)

2,146 (1,339.7–3,101.9)

13%

1893.5 (1198.1–2731.1)

2146 (1339.7–3101.9)

13%

  Tension-type headache

117.1 (65.8–188)

144.1 (82.7–233.9)

23%

117.1 (65.8–188)

144.1 (82.7–233.9)

23%

  Other neurological disorders

136.7 (102.7–176.2)

202.8 (153.7–261.7)

48%

424.5 (336.1–567.1)

633.1 (480.2–802.4)

49%

Mental and behavioral disorders

10,177.2 (8,247.3–12,325.7)

12,464.1 (10,170.8–15,032.3)

22%

10,528.7 (8,600.5–12,716.4)

12,917.2 (10,630.6–15,432.4)

23%

  Schizophrenia

771.1 (443.1–1,144.3)

1,052.2 (583.9–1,591.4)

36%

781.6 (453.6–1,153.9)

1,074.7 (606.8–1,614.1)

37%

  Alcohol use disorders

691 (381.2–1156.4)

757.1 (401.2–1,235.8)

10%

797 (482.4–1,257.7)

882.1 (514.8–1,385.4)

11%

  Drug use disorders

1,644.7 (1,176.5–2,156.1)

1,784.5 (1,277.6–2,334.5)

9%

1,873.5 (1,391–2,416.5)

2,076 (1,536.1–2,677.5)

11%

  Opioid use disorders

746.5 (502.9–1003.1)

844.4 (571.9–1,134.8)

13%

886.9 (629.1–1,165.1)

1,016.2 (728.8–1,339.5)

15%

  Cocaine use disorders

195.6 (112.9–306.5)

216.7 (124.3–335)

11%

199.3 (117.2–313.6)

218.6 (124.8–338.9)

10%

  Amphetamine use disorders

155.2 (86.9–249.2)

162.1 (91.4–255.5)

4%

157.2 (88.8–251.8)

164.5 (92.3–262.9)

5%

  Cannabis use disorders

213.6 (107.1–377.3)

201.5 (100.3–367.1)

−6%

213.6 (107.1–377.3)

201.5 (100.3–367.1)

−6%

  Other drug use disorders

333.8 (205.6–499.4)

359.8 (226.7–523.5)

8%

416.4 (280.9–592.2)

475.1 (327–669.2)

14%

  Unipolar depressive disorders

4,011.1 (2,829.7–5,395.6)

5,308.1 (3,910.9–7,025.8)

32%

4,011.1 (2,829.7–5,395.6)

5,308.1 (3,910.9–7,025.8)

32%

  Major depressive disorder

3,352.4 (2,332.1–4,626.6)

4,521.8 (3,227.7–6,093.6)

35%

3,352.4 (2,332.1–4,626.6)

4,521.8 (3,227.7–6,093.6)

35%

  Dysthymia

658.7 (426.3–922.7)

786.3 (508.1–1,094.9)

19%

658.7 (426.3–922.7)

786.3 (508.1–1,094.9)

19%

  Bipolar affective disorder

696.1 (425.1–1051)

835.3 (510.6–1,251.2)

20%

696.1 (425.1–1051)

835.3 (510.6–1251.2)

20%

  Anxiety disorders

1,213.6 (826.9–1,673.9)

1331.1 (906.8–1,856.4)

10%

1,213.6 (826.9–1,673.9)

1,331.1 (906.8–1,856.4)

10%

  Eating disorders

296.4 (171.5–476.8)

570.1 (334.2–924.9)

92%

298.7 (174.6–479.3)

574.6 (339.7–929.5)

92%

  Pervasive development disorders

399.8 (269.4–578.2)

452.2 (302.8–648.9)

13%

399.8 (269.4–578.2)

452.2 (302.8–648.9)

13%

  Autism

188.8 (122.7–275.7)

216.3 (140.4–317.6)

15%

188.8 (122.7–275.7)

216.3 (140.4–317.6)

15%

  Asperger’s syndrome

211.1 (134.8–319.5)

235.8 (154.4–352.7)

12%

211.1 (134.8–319.5)

235.8 (154.4–352.7)

12%

  Childhood behavioral disorders

291.8 (171.3–450.9)

209.7 (120.2–323.4)

−28%

291.8 (171.3–450.9)

209.7 (120.2–323.4)

−28%

  Attention-deficit hyperactivity disorder

27 (15.2–43.6)

20.8 (11.8–33.8)

−23%

27 (15.2–43.6)

20.8 (11.8–33.8)

−23%

  Conduct disorder

264.7 (151–419.6)

188.9 (105–299.2)

−29%

264.7 (151–419.6)

188.9 (105–299.2)

−29%

  Idiopathic intellectual disability

92 (53.5–142.5)

74.1 (38–123.4)

−19%

92 (53.5–142.5)

74.1 (38–123.4)

−19%

  Other mental and behavioral disorders

69.5 (41–108.2)

89.7 (52–143.5)

29%

73.4 (44.8–112.2)

99.2 (60.1–152.2)

35%

Diabetes, urogenital, blood, and endocrine diseases

4,245.7 (3,050.2–5,693.7)

5,381.9 (3,956.8–7,145.9)

27%

7,013.4 (5,814.5–8,532.3)

8,414.8 (6,968.8–1,0395.6)

20%

  Diabetes mellitus

2,207.8 (1461.1–3173)

2,807.9 (1,906.5–4,022.5)

27%

3,490.7 (2,731.4–4,487.2)

3,954.2 (3,014.9–5,187.7)

13%

  Acute glomerulonephritis

0 (0–0.1)

0 (0–0)

−9%

3.8 (2.4–6.7)

2.5 (1.1–3.9)

−34%

  Chronic kidney diseases

537.1 (370.6–805.8)

770.3 (538.4–1101)

43%

1,371.7 (1,146.5–1,649.9)

1,590.2 (1,313.1–1,967.6)

16%

  Chronic kidney disease due to diabetes mellitus

80.8 (52.9–117.2)

119.3 (78.1–172.1)

48%

214.8 (173.7–261.2)

242 (190.6–308.7)

13%

  Chronic kidney disease due to hypertension

99.2 (66.2–147.1)

143.9 (97.4–204.3)

45%

264.7 (219.2–322.4)

315.3 (257.2–393.6)

19%

  Chronic kidney disease unspecified

357.1 (240.4–547.6)

507.1 (352.2–735)

42%

892.2 (740.5–1101.4)

1,032.9 (841.5–1,303.6)

16%

  Urinary diseases and male infertility

395.5 (254.4–603.1)

541.2 (347.1–812.7)

37%

604.2 (451.8–809.5)

963.5 (717.5–1,265.4)

59%

  Tubulointerstitial nephritis, pyelonephritis, and urinary tract infections

5.9 (2.6–11.2)

7.4 (3.5–14.3)

27%

156.5 (124.4–229.1)

328.8 (177.1–474.9)

110%

  Urolithiasis

50 (27.3–81.3)

72.6 (40.1–114.7)

45%

59.1 (36–91.8)

78.8 (46.4–122.1)

33%

  Benign prostatic hyperplasia

319.6 (201.5–487.1)

431.8 (270.1–654.1)

35%

319.6 (201.5–487.1)

431.8 (270.1–654.1)

35%

  Male infertility

3.2 (1.2–7.1)

4.2 (1.6–9)

32%

3.2 (1.2–7.1)

4.2 (1.6–9)

32%

  Other urinary diseases

16.9 (9.5–27.4)

25.1 (14.1–40.3)

49%

65.9 (51.6–86)

119.8 (87.9–155.5)

82%

  Gynecological diseases

464.2 (258.8–797)

585.2 (325.2–999)

26%

468.9 (263.7–801.4)

590.4 (330–1,004)

26%

  Uterine fibroids

96.8 (43.5–190.7)

139.2 (60.2–268.9)

44%

97.2 (43.9–191.1)

139.7 (60.8–269.4)

44%

  Polycystic ovarian syndrome

142.4 (66.4–265.2)

170.3 (77.9–324.2)

20%

142.4 (66.4–265.2)

170.3 (77.9–324.2)

20%

  Female infertility

2.5 (0.9–5.4)

3.1 (1.1–6.7)

24%

2.5 (0.9–5.4)

3.1 (1.1–6.7)

24%

  Endometriosis

27.1 (9–52.7)

34.3 (12.4–66.5)

27%

27.1 (9–52.7)

34.3 (12.4–66.5)

27%

  Genital prolapse

123.8 (49.5–259.5)

156.3 (62.6–339.3)

26%

124.2 (49.9–259.9)

156.7 (63–339.7)

26%

  Premenstrual syndrome

71.7 (0–200.2)

82.1 (0–213.6)

14%

71.7 (0–200.2)

82.1 (0–213.6)

14%

  Other gynecological diseases

0 (0–0)

0 (0–0)

–*

3.9 (3.4–4.6)

4.2 (3.3–5.4)

10%

  Hemoglobinopathies and hemolytic anemia

498.7 (296.2–1080.4)

477.4 (291.8–935)

−4%

599.4 (393.7–1,169.3)

540.7 (350.5–997.4)

−10%

  Thalassemia

161.4 (102.1–247.1)

156.1 (99.3–254.6)

−3%

174.9 (115.5–260.7)

162.3 (105.8–260.9)

−7%

  Sickle cell disorders

309.9 (171.6–832.4)

296.2 (172.1–703.8)

−4%

338.4 (199.5–859.6)

309.3 (184.8–715.3)

−9%

  G6PD deficiency

24.8 (11.7–93.6)

18.3 (9.3–58.9)

−26%

32.5 (19–101.1)

22.5 (13.2–62.6)

−31%

  Other hemoglobinopathies and hemolytic anemia

2.5 (0.5–1.8)

6.7 (0.9–9.3)

169%

53.6 (36.2–64.7)

46.6 (31.4–79.2)

−13%

  Other endocrine, nutritional, blood, and immune disorders

142.4 (83.1–228.4)

199.8 (115.9–362)

40%

474.8 (329.2–710.6)

773.4 (529.7–1,539.3)

63%

Musculoskeletal disorders

11,220.4 (,8585.2–14,277.6)

14,278.5 (10,905.8–17,775.5)

27%

11,469.4 (88,29.8–14,558.2)

14,654.1 (11,291.8–18,160.2)

28%

  Rheumatoid arthritis

477.5 (345.2–636.5)

665.5 (465.5–881)

39%

519.4 (384.9–684.3)

710.1 (509.5–925.6)

37%

  Osteoarthritis

1,055.3 (648.4–1,604.3)

1,407.1 (877.8–2,066.2)

33%

1,055.3 (648.4–1,604.3)

1,407.1 (877.8–2,066.2)

33%

  Low back and neck pain

7,363.4 (5,148.2–9,886.3)

9,178.1 (6,357.5–12,295.1)

25%

7,363.4 (5,148.2–9,886.3)

9,178.1 (6,357.5–1,2295.1)

25%

  Low back pain

4,784.5 (3,305.8–6,484.6)

6,011.7 (4,104.5–8,080.9)

26%

4,784.5 (3,305.8–6,484.6)

6,011.7 (4,104.5–8,080.9)

26%

  Neck pain

2,578.9 (1,769.5–3,608.8)

3,166.3 (2,193.9–4,438)

23%

2,578.9 (1,769.5–3,608.8)

3,166.3 (2,193.9–4,438)

23%

  Gout

21.6 (13.4–32.1)

30.2 (19–45.1)

40%

21.6 (13.4–32.1)

30.2 (19–45.1)

40%

  Other musculoskeletal disorders

2,302.7 (1,585.5–3,228.6)

2,997.7 (2,089.4–4,136.6)

30%

2,509.7 (1,803.7–3,433.4)

3,328.7 (2,440.8–4,471.4)

33%

Other non-communicable diseases

4,700.2 (3,172.4–6,899.1)

5,087.8 (3,400.3–7,616.6)

8%

6,009.2 (4,467.8–8,218.2)

5,881.5 (4,184.3–8,375.2)

−2%

  Congenital anomalies

130.9 (93.7–182.5)

141 (101.2–201.8)

8%

1,278.3 (1,065.6–1,416.6)

778.7 (685.8–973.5)

−39%

  Neural tube defects

11.6 (6.4–18.7)

8.2 (4.4–13.6)

−29%

99.4 (58.5–126.5)

18.5 (12.5–28)

−81%

  Congenital heart anomalies

34.2 (17.6–66.8)

32.4 (15.9–67.4)

−5%

566.6 (460.8–650.2)

321.4 (254.9–411.9)

−43%

  Cleft lip and cleft palate

5.4 (2.7–9.7)

6 (3.1–10.5)

12%

7.9 (4.9–12.4)

7.4 (4.3–12.1)

−6%

  Down’s syndrome

38.1 (21.6–61.4)

46.5 (27.1–74.6)

22%

104 (69.3–138.5)

104.7 (80.1–136)

1%

  Other chromosomal abnormalities

14.5 (8–23.9)

17.4 (10.1–29.2)

19%

59.4 (41.1–78.5)

55 (39.2–77.1)

−7%

  Other congenital anomalies

27.1 (19.1–38.3)

30.6 (21.8–44.9)

13%

441 (294.4–539.7)

271.6 (215.5–397.8)

−38%

  Skin and subcutaneous diseases

1,989.9 (1,235.6–3,086)

2,206.8 (1,347–3,476.9)

11%

2,058.2 (1,302–3,150.8)

2,301.8 (1,445–3,558.5)

12%

  Eczema

462.2 (233.8–802)

511.7 (252.5–845.6)

11%

462.2 (233.8–802)

511.7 (252.5–845.6)

11%

  Psoriasis

87.3 (42.4–145.8)

105.1 (50–172.9)

20%

87.3 (42.4–145.8)

105.1 (50–172.9)

20%

  Cellulitis

11.1 (1.2–45.6)

11 (1.3–45.3)

−1%

26.2 (15.7–60.2)

29.6 (16.9–63.8)

13%

  Abscess, impetigo, and other bacterial skin diseases

41.8 (16.9–85.1)

49.3 (19.8–101.3)

18%

63.3 (38–107.4)

76 (45.7–129.6)

20%

  Scabies

22.9 (10.1–44.9)

26.2 (11.8–49)

15%

22.9 (10.1–44.9)

26.2 (11.8–49)

15%

  Fungal skin diseases

107.6 (33.8–246.6)

128.2 (39.3–291.8)

19%

107.6 (33.8–246.6)

128.2 (39.3–291.8)

19%

  Viral skin diseases

189.2 (72.5–359.4)

182.5 (66.3–336.4)

−4%

189.2 (72.5–359.4)

182.5 (66.3–336.4)

−4%

  Acne vulgaris

312.6 (139.6–589.8)

237.6 (106.6–469.3)

−24%

312.6 (139.6–589.8)

237.6 (106.6–469.3)

−24%

  Alopecia areata

78.7 (23–158.4)

91.1 (25.1–182.4)

16%

78.7 (23–158.4)

91.1 (25.1–182.4)

16%

  Pruritus

179.4 (82.5–347.4)

244.2 (110.2–489.4)

36%

179.4 (82.5–347.4)

244.2 (110.2–489.4)

36%

  Urticaria

137.4 (55.3–236.9)

159 (65–271)

16%

137.4 (55.3–236.9)

159 (65–271)

16%

  Decubitus ulcer

30 (9.8–69.2)

40.3 (12.9–96.9)

34%

61.5 (39.8–101.6)

89.7 (55–150.1)

46%

  Other skin and subcutaneous diseases

329.6 (155.1–610.6)

420.8 (193.8–806.2)

28%

329.8 (155.2–610.6)

421 (193.9–806.3)

28%

Sense organ diseases

1637 (1164–2335)

1,850.2 (1291.1–2,656.9)

13%

1,637 (1,164–2,335)

1,850.2 (1,291.1–2,656.9)

13%

  Glaucoma

36 (23–54.9)

56.9 (37.6–82.7)

58%

36 (23–54.9)

56.9 (37.6–82.7)

58%

  Cataracts

193.1 (136.8–261.7)

170.7 (116.3–233.8)

−12%

193.1 (136.8–261.7)

170.7 (116.3–233.8)

−12%

  Macular degeneration

58.4 (37.5–87.3)

107.8 (71.8–152.9)

85%

58.4 (37.5–87.3)

107.8 (71.8–152.9)

85%

  Refraction and accommodation disorders

84 (61.3–110.7)

107.9 (77.6–142.3)

28%

84 (61.3–110.7)

107.9 (77.6–142.3)

28%

  Other hearing loss

926.8 (541.4–1480.3)

962.7 (554.5–1598.5)

4%

926.8 (541.4–1,480.3)

962.7 (554.5–1,598.5)

4%

  Other vision loss

329.9 (174.9–586)

433.2 (222–771)

31%

329.9 (174.9–586)

433.2 (222–771)

31%

  Other sense organ diseases

8.8 (3–19.8)

11 (3.7–25.4)

25%

8.8 (3–19.8)

11 (3.7–25.4)

25%

Oral disorders

942.4 (564.3–1507.7)

889.8 (519.4–1403.9)

−6%

942.4 (564.3–1,507.7)

889.8 (519.4–1,403.9)

−6%

Dental caries

110.2 (45–216.1)

130.4 (52.8–250.1)

18%

110.2 (45–216.1)

130.4 (52.8–250.1)

18%

Periodontal disease

143 (54.8–312.3)

193.8 (72.6–400.1)

36%

143 (54.8–312.3)

193.8 (72.6–400.1)

36%

Edentulism

689.2 (394.8–1103.5)

565.6 (322–903)

−18%

689.2 (394.8–1103.5)

565.6 (322–903)

−18%

Sudden infant death syndrome

0 (0–0)

0 (0–0)

–*

93.3 (40.6–150.8)

61 (31.4–111.4)

−35%

Injuries

3,873.3 (2,679.9–5,500.9)

5,495 (3,846.6–7,727.1)

42%

11,961.1 (10,559.1–13,749.9)

9,962.5 (8,154–12,170.7)

−17%

Transport injuries

1,134 (763.2–1,670.3)

1,428.6 (975–2,074.9)

26%

4,925.5 (4,315.5–5,683.5)

3,047.6 (2,494.2–3,809.3)

−38%

  Road injury

982.9 (659–1,450.2)

1,197.1 (810.2–1,745.7)

22%

4,671.5 (4,049.7–5,342.3)

2,692.9 (2,226.1–3,328.1)

−42%

  Pedestrian injury by road vehicle

169 (113.6–248.3)

243.2 (165–350.8)

44%

580.3 (487.4–761.5)

464.4 (372.3–584.4)

−20%

  Pedal cycle vehicle

18.8 (12.7–27.8)

50.5 (34.2–74.1)

169%

71.2 (53.8–110.9)

107.2 (75.3–136.5)

51%

  Motorized vehicle with two wheels

232.4 (155.6–347.3)

172.6 (116.1–252.7)

−26%

1,423.3 (1,009.6–1,638.8)

436 (360.3–539.5)

−69%

  Motorized vehicle with three or more wheels

576.6 (386.6–852.7)

779.7 (527.3–1134.8)

35%

2,579.1 (2,156.9–3,157.2)

1,722.1 (1,368.2–2,279.8)

−33%

  Road injury other

13 (8.8–19.2)

12.1 (8.2–17.4)

−7%

44.6 (31.7–60)

24 (17.7–33.7)

−46%

  Other transport injury

151.1 (102.4–223)

231.5 (157.9–331.2)

53%

254 (189.8–359.6)

354.8 (275.4–460.4)

40%

Unintentional injuries other than transport injuries

2,638 (1,821–3,727.8)

3,944 (2,760.5–5,515.8)

50%

5,486.5 (4,503.8–6,659)

5,472.7 (4,205.3–7,082.7)

0%

  Falls

2,150.2 (1,471.2–3043.3)

3,315.8 (2,316.6–4,644.3)

54%

2,462.8 (1,754.8–3,385.5)

3,763.4 (2,726.7–5,125)

53%

  Drowning

9.7 (6.1–14.5)

11.1 (7–16.8)

14%

404.4 (312.7–497.3)

222.8 (181–295.5)

−45%

  Fire, heat and hot substances

57 (30.5–106.3)

70.2 (37.6–127.1)

23%

158.1 (122.4–213)

141 (105.1–202.2)

−11%

  Poisonings

9.2 (5.6–14.6)

7.1 (4.3–11.3)

−23%

220.6 (153.6–338.5)

165.9 (79.7–233.9)

−25%

  Exposure to mechanical forces

72.6 (45.5–114)

75.2 (47.8–113.9)

4%

269.1 (212.6–366.4)

185.4 (130.8–252.4)

−31%

  Mechanical forces (firearm)

26.9 (17–42.2)

14.6 (9.4–22.2)

−46%

94.8 (56.5–123)

31.6 (22.7–47.7)

−67%

  Mechanical forces (other)

56.5 (35.4–88.2)

79.1 (50.2–119.5)

40%

185.1 (147.6–282.1)

172.3 (131.7–241.7)

−7%

  Adverse effects of medical treatment

45.3 (29.2–68.3)

102.6 (66–151.3)

127%

143.5 (115.6–181.7)

227.3 (174.5–307.9)

58%

  Animal contact

21.9 (14.2–32.8)

11.7 (7.7–17.2)

−47%

35.3 (26.2–47.7)

18.6 (14–25.1)

−47%

  Animal contact (venomous)

14.3 (8.7–22.3)

6.8 (4.3–10.5)

−53%

16.4 (10.6–24.8)

8.3 (5.6–12.2)

−50%

  Animal contact (non-venomous)

7.6 (4.8–11.8)

4.9 (3–7.3)

−36%

18.9 (13.9–24.7)

10.3 (7.8–13.9)

−45%

  Unintentional injuries not classified elsewhere

272.1 (185.1–396.4)

350.3 (232.7–505.7)

29%

1,792.7 (1,054.8–2,031)

748.2 (605.7–955.4)

−58%

Self-harm and interpersonal violence

101.3 (66.6–146.4)

122.3 (81.1–173)

21%

1,549.1 (1,277.2–2,016.4)

1,442.2 (1,051.7–1,690.9)

−7%

  Self-harm

12.6 (7.9–18.3)

15.2 (9.7–23.1)

21%

1,244.6 (9,62.4–1,686.8)

1,154.4 (7,59.7–1,377.5)

−7%

  Interpersonal violence

88.7 (58.4–129.4)

107.1 (70.8–151.4)

21%

304.5 (241.9–403)

287.8 (230.5–369.8)

−5%

  Assault by firearm

23.2 (15–34.3)

30.1 (19.5–42.9)

30%

74.6 (59–105.3)

74.2 (57.3–98.9)

−1%

Assault by sharp object

31.9 (20.9–46.9)

56.2 (37–79.6)

76%

106.7 (79.1–175.7)

143.2 (94.8–186.6)

34%

  Assault by other means

40.1 (26.5–57.7)

31.3 (21–43.8)

−22%

129.7 (98.4–158.1)

80.9 (65.5–106)

−38%

  1. Data are presented as mean values and uncertainty intervals (Lower, Upper).
  2. *– not applicable.