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Table 3 The levels of thyroid hormone profile in children conceived by natural conception (NC), fresh embryo transfer (ET), and frozen ET

From: Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study

 

NC

Fresh ET

Frozen ET

Fresh ET vs. NC Crude P

Fresh ET vs. Frozen ET Crude P

Frozen ET vs. NC Crude P

(n = 380)

(n = 357)

(n = 212)

(Adjusted P )

(Adjusted P )

(Adjusted P )

T3 (nmol/L)

2.28 ± 0.22

2.31 ± 0.32

2.31 ± 0.41

0.06 (0.09)

0.78 (0.77)

0.25 (0.32)

FT3 (pmol/L)

5.92 ± 0.61

6.01 ± 0.73

5.98 ± 0.91

0.07 (0.07)

0.65 (0.83)

0.36 (0.20)

T4 (nmol/L)

100.1 ± 17.06

105.81 ± 16.82

100.76 ± 15.75

<0.01 (<0.01)

<0.01 (<0.01)

0.64 (0.91)

FT4 (pmol/L)

15.76 ± 1.67

16.55 ± 1.74

16.46 ± 1.61

<0.01 (<0.01)

0.54 (0.69)

<0.01 (<0.01)

TSH (mIU/L)

2.35 ± 0.96

2.69 ± 1.37

2.41 ± 0.98

<0.01 (<0.01)

<0.01 (<0.01)

0.49 (0.51)

  1. Data are shown as mean ± SD.
  2. Log transformations were conducted when the normality assumption was not satisfied. Adjusted P values were calculated by linear regression adjusted for age of child, type of assisted reproduction, sex of child, or maternal variables (obstetric complications).