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Table 4 Sex-stratified multilevel Cox models

From: Sex dependent risk factors for mortality after myocardial infarction: individual patient data meta-analysis

 

Female

Male

Inter.

HR*

95% CI

P

HR*

95% CI

P

P †

Demographics

       

Age <50

0.7

(0.4–1.1)

0.087

0.4

(0.3–0.6)

<0.001

0.076‡

Age >70

2.5

(2.0–3.1)

<0.001

2.9

(2.5–3.3)

<0.001

0.17

Heart disease

       

History of MI

1.8

(1.4–2.3)

<0.001

1.7

(1.5–2.0)

<0.001

0.99

LVEF <40%

1.3

(1.1–1.6)

0.018

1.7

(1.5–2.0)

<0.001

0.018‡

Killip class II–IV

2.1

(1.7–2.6)

<0.001

2.1

(1.8–2.4)

<0.001

0.41

Beta-blocker use

0.7

(0.6–0.9)

0.001

0.8

(0.7–0.9)

0.001

0.72

Comorbidity

       

Diabetes

1.8

(1.4–2.2)

<0.001

1.7

(1.5–2.0)

<0.001

0.89

Depression low

0.8

(0.6–1.1)

0.27

0.9

(0.7–1.0)

0.13

0.67

Depression high

1.1

(0.9–1.4)

0.41

1.4

(1.2–1.6)

<0.001

0.054‡

Antidepressant use

1.2

(0.8–1.6)

0.37

1.3

(1.1–1.7)

0.017

0.36

General health

       

Hyperlipidaemia

1.0

(0.8–1.2)

1.0

0.8

(0.7–1.0)

0.037

0.26‡

Smoking

0.9

(0.7–1.2)

0.54

1.2

(1.0–1.4)

0.068

0.48

BMI <20

1.4

(1.0–2.1)

0.071

1.3

(0.9–1.8)

0.14

0.91

BMI >30

0.9

(0.7–1.1)

0.33

0.9

(0.7–1.1)

0.19

0.64

  1. BMI, Body mass index; CI, Confidence interval; HR, Hazard ratio; Inter., Interaction; LVEF, Left ventricular ejection fraction; MI, Myocardial infarction; P, P value.
  2. *HR’s, CI’s and P values for sex-stratified multivariate multilevel Cox models in the training data (n = 8,410).
  3. † P value of two-way interactions between sex and all other risk factors based on addition of the interaction to the unstratified multilevel Cox model (such as in Table 3) one at the time.
  4. ‡ P value of the sex-related interactions selected by Lasso.
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BMC Medicine

ISSN: 1741-7015

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