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Table 1 Characteristics of included studies on influenza vaccine effectiveness in patients with end-stage renal disease

From: Influenza vaccination in patients with end-stage renal disease: systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety

Author, country [Ref] Study design, year Age in years Male patients (%) Years on dialysis Patients on hemodialysis (%) Diagnosis of renal disease, identification of patients Predominantly circulating influenza strains Study size
(mean ± SD or range) (mean ± SD or range)
Bond et al., US [25] Cohort, 2005–2006 vacc.: 60.6 ± 15.2 vacc.: 50.8 vacc.: 4.5 ± 3 .6 vacc.: 92.6 USRDS; ICD-9-CM codes Not reported vacc.: n = 14,226
unvacc.: 57.9 ± 15.9 unvacc.: 52.5 unvacc.: 4.8 ± 4.1 unvacc.: 90.4 unvacc.: n = 5,994
Gilbertson et al., US [24]1 Cohort, 1997–1999 vacc.: 40–64: 36.3%; 65+: 53.8% vacc.: 40.3 Proportion > 4 yrs on dialysis: 01 USRDS; ICD-9-CM codes1 Not reported Patients on peritoneal dialysis: n = 13,091
unvacc.: 40–64: 64.7%; 65+: 46.2% unvacc.: 59.7 vacc: 35.9%
unvacc.: 37.7%
McGrath et al., US [26] Cohort, 1997–1999, 2001 vacc.: 62.3–63.92 vacc.: 52.2-53.02 Proportion > 4 yrs on dialysis: 100 USRDS; ICD-9-CM codes H3N2 (all seasons) vacc.: n = 52,287–61,8002
unvacc.: 60.3–61.72 unvacc.: 50.4-51.62 vacc.: 29.2-30.9%2 unvacc.: n = 55,178–64,8992
unvacc.: 32.5-34.1%2
Slinin et al., US [27] Cohort, 1993–1994 all: 60.3 all: 51.1 Proportion < 5 yrs on dialysis: 100 USRDS; ICD-9-CM codes Not reported all: n = 10,635
all: 75.8%
Wang et al., Taiwan [23] Cohort, 1998–2009 vacc.: 70.2 ± 9.96 vacc.: 50.3 Patients with “newly diagnosed” ESRD 100 Universal insurance data, National Health Insurance program Not reported vacc.: n = 831 unvacc.: n = 3,187
unvacc.: 59.4 ± 14.5 unvacc.: 48.7
Total study population        Total: n = 174,6633
  1. ESRD, end-stage renal disease; vacc., vaccinated; unvacc., non-vaccinated.
  2. 1Since Gilbertson et al. and McGrath et al. used the same database, but McGrath included patients on hemodialysis only, patients on peritoneal dialysis were extracted from the study of Gilbertson et al.
  3. 2Range over 4 seasons.
  4. 3Since all US studies used the same database, overlapping of the populations cannot be ruled out.
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