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Table 2 Blood transfusion guidelines used by clinicians in the FEAST trial

From: Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness

Guidelines Indications for transfusion Volume and speed of transfusion
Haemoglobin level (g/dL)   Clinical symptoms
WHO Pocket Book of Hospital Care for Children (2005)* 4 or less   Not required 20 mL/kg whole blood or 10 mL/kg packed cells over 3 to 4 hours
OR   
6 or less PLUS 1 or more Deep and laboured breathing
Cardiac failure
Clinical dehydration
Shock
Impaired consciousness
Malaria parasitaemia >10%
Kenya Guidelines for Appropriate Use of Blood and Blood Products (2004)* Less than 4   Not required 20 mL/kg whole blood over 3 to 4 hours
OR   
Less than 5 PLUS Respiratory distress
Ugandan National Guidelines (2010)* 4 or less   Not required 20 mL/kg whole blood or 10 mL/kg packed cells over 3 to 4 hours
OR   
6 or less PLUS 1 or more Hypoxia
Cardiac decompensation
Acidosis
Impaired consciousness
Cerebral malaria
Septicaemia
Meningitis
Malaria parasitaemia >20%
Tanzania National Malaria Guidelines (2006)* 4 or less   Not required 20 mL/kg whole blood or 10 mL/kg packed cells over 3 to 4 hours
OR   
6 or less PLUS Cardiac failure
  1. *Version of guidelines available at the time of the FEAST trial.