Profile of time outside therapeutic range in regular medical care and coagulation service.(A) Relative frequency of time below therapeutic range. (B)Relative frequency of time above therapeutic range. Box-plots of profile of time outside therapeutic range of regular medical care and coagulation service. Time outside therapeutic range is presented as median (first quartile/third quartile); mean values are depicted graphically as asterisks within box-plots. Variability of frequency outside therapeutic range is expressed by median absolute deviation, P value for Ansari-Bradley test.