Figure 4

Association of the identified omics modules with clinical traits. Results are derived from linear (continuous traits, log-transformed) and logistic (binary traits) regression models adjusted for age, sex, body weight, lipid-lowering medication (overall, statin, fibrates), antihypertensive medication, antidiabetic medication as well as systemic corticoid intake. Significant associations (P <6.9 × 10⁻⁴ corresponding to Bonferroni correction for 72 tests) are denoted as black stars. 2hGlc, glucose two hours post challenge during an oral glucose tolerance test; CRP, C-reactive protein; DBP, diastolic blood pressure; FGlc, fasting glucose; GenM, gene expression module; HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; MetM, metabolite module; metS, metabolic syndrome; MI, myocardial infarction; SBP, systolic blood pressure; TG, trigylcerides. See Table S5 in Additional file 2 for descriptives of clinical traits. For disease definitions, see Methods.