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Table 3 Summary of evidence for mixed arterial/venous ulcer management

From: Seeking effective interventions to treat complex wounds: an overview of systematic reviews

Outcome Intervention Systematic reviews with MA Systematic reviews without MA
High-quality* Low/moderate quality High-quality** Low/moderate quality
Wound area/size reduction (MAs: 3) [34,65] Silver treatments (topical) and silver-impregnated dressings NA +/− NA NA
Ultrasound NA + NA NA
Ulcer healing (MAs: NA; non-MAs: 6) [80,82-84,101,110] Antimicrobial (topical and oral) NA NA NA
Electromagnetic therapy NA NA NA +
Honey (topical) NA NA NA +/−
  Ketanserin ointment, 2% (topical) NA NA NA +/−
  Standardized wound treatment protocol NA NA NA +
  Silver releasing dressing NA NA NA
Time to healing or rate of healing (MAs: 5) [45,49,55,56] Topical negative pressure NA + NA NA
Four-layer bandage + NA NA NA
Micronized purified flavonoid fraction (oral) NA + NA NA
Micronized purified flavonoid fraction (oral) NA + NA NA
Polyurethane (dressing) NA NA NA
Alginate (beads, paste + dressing, alginate dressing) NA NA NA
Proportion of patients with healed wounds (MAs: 3) [49,50] Silver dressings (topical or impregnated) NA NA NA
Topical negative pressure NA + NA NA
  1. *At least one systematic review with meta-analysis and AMSTAR score ≥8.
  2. **At least one systematic review without meta-analysis and AMSTAR score ≥8.
  3. + Effective (statistically significant difference between interventions and comparators); – No difference (no statistically significant difference between interventions and comparators); +/− Unknown (conflicting evidence between meta-analysis or indeterminate results); NA, No studies available; MA, Meta-analysis.