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Table 3 Summary of evidence for mixed arterial/venous ulcer management

From: Seeking effective interventions to treat complex wounds: an overview of systematic reviews

Outcome

Intervention

Systematic reviews with MA

Systematic reviews without MA

High-quality*

Low/moderate quality

High-quality**

Low/moderate quality

Wound area/size reduction

(MAs: 3) [34,65]

Silver treatments (topical) and silver-impregnated dressings

NA

+/−

NA

NA

Ultrasound

NA

+

NA

NA

Ulcer healing

(MAs: NA; non-MAs: 6) [80,82-84,101,110]

Antimicrobial (topical and oral)

NA

NA

NA

–

Electromagnetic therapy

NA

NA

NA

+

Honey (topical)

NA

NA

NA

+/−

 

Ketanserin ointment, 2% (topical)

NA

NA

NA

+/−

 

Standardized wound treatment protocol

NA

NA

NA

+

 

Silver releasing dressing

NA

NA

–

NA

Time to healing or rate of healing

(MAs: 5) [45,49,55,56]

Topical negative pressure

NA

+

NA

NA

Four-layer bandage

+

NA

NA

NA

Micronized purified flavonoid fraction (oral)

NA

+

NA

NA

Micronized purified flavonoid fraction (oral)

NA

+

NA

NA

Polyurethane (dressing)

–

NA

NA

NA

Alginate (beads, paste + dressing, alginate dressing)

–

NA

NA

NA

Proportion of patients with healed wounds

(MAs: 3) [49,50]

Silver dressings (topical or impregnated)

NA

–

NA

NA

Topical negative pressure

NA

+

NA

NA

  1. *At least one systematic review with meta-analysis and AMSTAR score ≥8.
  2. **At least one systematic review without meta-analysis and AMSTAR score ≥8.
  3. + Effective (statistically significant difference between interventions and comparators); – No difference (no statistically significant difference between interventions and comparators); +/− Unknown (conflicting evidence between meta-analysis or indeterminate results); NA, No studies available; MA, Meta-analysis.