From: Seeking effective interventions to treat complex wounds: an overview of systematic reviews
Outcome | Intervention | Systematic reviews with MA | Systematic reviews without MA | ||
---|---|---|---|---|---|
High-quality* | Low/moderate quality | High-quality** | Low/moderate quality | ||
Wound area/size reduction | Silver treatments (topical) and silver-impregnated dressings | NA | +/− | NA | NA |
Ultrasound | NA | + | NA | NA | |
Ulcer healing | Antimicrobial (topical and oral) | NA | NA | NA | – |
Electromagnetic therapy | NA | NA | NA | + | |
Honey (topical) | NA | NA | NA | +/− | |
 | Ketanserin ointment, 2% (topical) | NA | NA | NA | +/− |
 | Standardized wound treatment protocol | NA | NA | NA | + |
 | Silver releasing dressing | NA | NA | – | NA |
Time to healing or rate of healing | Topical negative pressure | NA | + | NA | NA |
Four-layer bandage | + | NA | NA | NA | |
Micronized purified flavonoid fraction (oral) | NA | + | NA | NA | |
Micronized purified flavonoid fraction (oral) | NA | + | NA | NA | |
Polyurethane (dressing) | – | NA | NA | NA | |
Alginate (beads, paste + dressing, alginate dressing) | – | NA | NA | NA | |
Proportion of patients with healed wounds | Silver dressings (topical or impregnated) | NA | – | NA | NA |
Topical negative pressure | NA | + | NA | NA |