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Table 7 Summary of evidence for infected surgical wounds management

From: Seeking effective interventions to treat complex wounds: an overview of systematic reviews

Outcome Intervention Systematic reviews with MA Systematic reviews without MA
High-quality* Low/moderate quality High-quality** Low/moderate quality
Proportion of patients with healed wounds (MAs: 1) [37] Topical negative pressure/vacuum-assisted closure NA + NA NA
Vacuum-assisted closure NA + NA NA
Wound area/size reduction (MAs: NA; non-MAs: 2) [71,108] Alginate dressings NA NA NA
Foam dressings NA NA NA
Time to healing or rate of healing (MAs: NA; non-MAs: 5) [68,71,96,108,109] Alginate dressings NA NA +/− NA
Aloe vera dermal gel (topical) NA NA +/− NA
Dextranomer polysaccharide bead dressings NA NA +/− NA
Foam dressings NA NA NA
  Gauze + Aloe vera dressings NA NA +/− NA
  Honey (topical) NA NA   +
  Hydrocolloid dressings NA NA NA
  Plaster casting NA NA + NA
  Polyurethane foam and sheets dressings NA NA +/− NA
  Silicone elastomer foam dressings and polyurethane foam dressings NA NA NA
  Topical negative pressure NA NA NA
Ulcer healing (MAs: NA; non-MAs: 2) [71,108] Dextranomer polysaccharide bead dressings NA NA +/− NA
Polyurethane foam dressings NA NA +/− NA
  1. *At least one systematic review with meta-analysis and AMSTAR score ≥8.
  2. **At least one systematic review without meta-analysis and AMSTAR score ≥8.
  3. + Effective (statistically significant difference between interventions and comparators); – No difference (no statistically significant difference between interventions and comparators); +/− Unknown (conflicting evidence between meta-analysis or indeterminate results); NA, No studies available; MA, Meta-analysis.