From: Improved survival among colon cancer patients with increased differentially expressed pathways
Upstream regulator | Molecule type | Predicted activation state | P value of overlap | Genes in dataset (Number of regulators from data in network) |
---|---|---|---|---|
TGFB1 | Growth factor | Activated | 8.14 × 10-46 | 743 (20) |
Beta-estradiol | Chemical drug | Activated | 1.21 × 10-41 | 779 (24) |
TP53 | Transcription regulator | Inhibited | 1.41 × 10-37 | 616 (20) |
CDKN1A | Kinase | Inhibited | 4.35 × 10-35 | 485 (14) |
MYC | Transcription regulator | Activated | 4.59 × 10-36 | 660 (22) |
Calcitriol | Chemical drug | Inhibited | 4.51 × 10-34 | 538 (24) |
E2F1 | Transcription regulator | Activated | 1.71 × 10-30 | 397 (15) |