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Table 4 Top upstream regulators of genes significantly differentially expressed in dataset

From: Improved survival among colon cancer patients with increased differentially expressed pathways

Upstream regulator

Molecule type

Predicted activation state

P value of overlap

Genes in dataset (Number of regulators from data in network)

TGFB1

Growth factor

Activated

8.14 × 10-46

743 (20)

Beta-estradiol

Chemical drug

Activated

1.21 × 10-41

779 (24)

TP53

Transcription regulator

Inhibited

1.41 × 10-37

616 (20)

CDKN1A

Kinase

Inhibited

4.35 × 10-35

485 (14)

MYC

Transcription regulator

Activated

4.59 × 10-36

660 (22)

Calcitriol

Chemical drug

Inhibited

4.51 × 10-34

538 (24)

E2F1

Transcription regulator

Activated

1.71 × 10-30

397 (15)

  1. CDKN1A, Cyclin-dependent kinase inhibitor 1A; E2F1, E2F transcription factor 1; MYC, v-myc avian myelocytomatosis viral oncogene homolog; TGFB1, Transforming growth factor beta 1; TP53, Tumor protein p53.