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Table 4 Total mg/kg dose administered (median [IQR, (range)]) for artesunate and amodiaquine

From: The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

  FDC Co-blistered NFDC Loose NFDC-30 Loose NFDC-25
Artesunate dose (mg/kg) a     
<1 y 10.7 [9.4-12.5 , 7.5-16.7] 10.7 [9.6-12.3 , 7.5-20.5] 12.5 [10.6-13.7 , 8.3-17.9] 12.5 [10.7-14.1 , 9.5-15]
1 to <5 y 12.5 [10.7-15 , 5.4-30] 13.4 [11.2-15.2 , 4.8-30] 12.6 [11.5-13.6 , 6.8-30] 12.5 [11.3-13.4 , 10.4-14.1]
5 to <12 y 12.5 [10-15 , 7-20] 11.5 [9.7-13.7 , 5.5-21.4] 11.5 [10-12.5 , 6.8-15] 12.5 [11.9-13 , 11.5-13.4]
≥12 y 10.9 [9.5-13 , 5.8-21.4] 10.9 [9.4-13 , 6-24] 11.5 [10.9-12.1 , 7.5-14] 11.7 [11.2-12 , 7.8-12.5]
Overall 12 [10-14.5 , 5.4-30] 12.0 [10-15 , 4.8-30] 12.5 [11.1-13.5 , 6.8-30] 12.5 [11.5-13.1 , 7.8-15]
Amodiaquine dose (mg/kg) a     
<1 yb 28.9 [25.3-33.8 , 20.3-45] 32.6 [28.7-36.5 , 22.8-62.9] 33.9 [30.3-37 , 19-50] 22.9 [21.4-25 , 19-30]
1 to <5 y 33.8 [28.9-40.5 , 14.5-81] 38.3 [32.2-45.9 , 14.8-91.8] 33.3 [30-37.5 , 19.7-60] 25.0 [22.7-25 , 21.1-25]
5 to <12 y 33.8 [27-40.5 , 18.9-54] 35.3 [29.5-42 , 16.7-65.6] 34.1 [31.6-39.8 , 27.3-60] 24.1 [23.7-25 , 22.6-26]
≥12 y 29.5 [25.7-35.2 , 15.6-57.9] 33.4 [28.7-39.9 , 18-73.4] 38.9 [33.3-44.2 , 28.1-55.8] 24.0 [23.1-25 , 15.6-26]
Overall 32.4 [27-39 , 14.5-81] 35.3 [30.6-43.7 , 14.8-91.8] 33.7 [30.6-38.1 , 19-60] 25.0 [22.7-25 , 15.6-30]
  1. aThe overall median mg/kg amodiaquine dose administered was 32.1 mg/kg [IQR = 25.9-38.2, range = 14.5-91.8].
  2. The overall median mg/kg artesunate dose administered was 12.5 mg/kg [IQR = 10.7-13.6, range = 4.8-30].
  3. bIn children <1 year, the overall median mg/kg amodiaquine dose administered was 28.9 mg/kg [IQR = 25-35.1, range = 18.9-62.7].