| FDC | Co-blistered NFDC | Loose NFDC-30 | Loose NFDC-25 |
---|---|---|---|---|
Artesunate dose (mg/kg) a | Â | Â | Â | Â |
<1 y | 10.7 [9.4-12.5 , 7.5-16.7] | 10.7 [9.6-12.3 , 7.5-20.5] | 12.5 [10.6-13.7 , 8.3-17.9] | 12.5 [10.7-14.1 , 9.5-15] |
1 to <5 y | 12.5 [10.7-15 , 5.4-30] | 13.4 [11.2-15.2 , 4.8-30] | 12.6 [11.5-13.6 , 6.8-30] | 12.5 [11.3-13.4 , 10.4-14.1] |
5 to <12 y | 12.5 [10-15 , 7-20] | 11.5 [9.7-13.7 , 5.5-21.4] | 11.5 [10-12.5 , 6.8-15] | 12.5 [11.9-13 , 11.5-13.4] |
≥12 y | 10.9 [9.5-13 , 5.8-21.4] | 10.9 [9.4-13 , 6-24] | 11.5 [10.9-12.1 , 7.5-14] | 11.7 [11.2-12 , 7.8-12.5] |
Overall | 12 [10-14.5 , 5.4-30] | 12.0 [10-15 , 4.8-30] | 12.5 [11.1-13.5 , 6.8-30] | 12.5 [11.5-13.1 , 7.8-15] |
Amodiaquine dose (mg/kg) a | Â | Â | Â | Â |
<1 yb | 28.9 [25.3-33.8 , 20.3-45] | 32.6 [28.7-36.5 , 22.8-62.9] | 33.9 [30.3-37 , 19-50] | 22.9 [21.4-25 , 19-30] |
1 to <5 y | 33.8 [28.9-40.5 , 14.5-81] | 38.3 [32.2-45.9 , 14.8-91.8] | 33.3 [30-37.5 , 19.7-60] | 25.0 [22.7-25 , 21.1-25] |
5 to <12 y | 33.8 [27-40.5 , 18.9-54] | 35.3 [29.5-42 , 16.7-65.6] | 34.1 [31.6-39.8 , 27.3-60] | 24.1 [23.7-25 , 22.6-26] |
≥12 y | 29.5 [25.7-35.2 , 15.6-57.9] | 33.4 [28.7-39.9 , 18-73.4] | 38.9 [33.3-44.2 , 28.1-55.8] | 24.0 [23.1-25 , 15.6-26] |
Overall | 32.4 [27-39 , 14.5-81] | 35.3 [30.6-43.7 , 14.8-91.8] | 33.7 [30.6-38.1 , 19-60] | 25.0 [22.7-25 , 15.6-30] |