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Table 4 Total mg/kg dose administered (median [IQR, (range)]) for artesunate and amodiaquine

From: The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

 

FDC

Co-blistered NFDC

Loose NFDC-30

Loose NFDC-25

Artesunate dose (mg/kg) a

    

<1 y

10.7 [9.4-12.5 , 7.5-16.7]

10.7 [9.6-12.3 , 7.5-20.5]

12.5 [10.6-13.7 , 8.3-17.9]

12.5 [10.7-14.1 , 9.5-15]

1 to <5 y

12.5 [10.7-15 , 5.4-30]

13.4 [11.2-15.2 , 4.8-30]

12.6 [11.5-13.6 , 6.8-30]

12.5 [11.3-13.4 , 10.4-14.1]

5 to <12 y

12.5 [10-15 , 7-20]

11.5 [9.7-13.7 , 5.5-21.4]

11.5 [10-12.5 , 6.8-15]

12.5 [11.9-13 , 11.5-13.4]

≥12 y

10.9 [9.5-13 , 5.8-21.4]

10.9 [9.4-13 , 6-24]

11.5 [10.9-12.1 , 7.5-14]

11.7 [11.2-12 , 7.8-12.5]

Overall

12 [10-14.5 , 5.4-30]

12.0 [10-15 , 4.8-30]

12.5 [11.1-13.5 , 6.8-30]

12.5 [11.5-13.1 , 7.8-15]

Amodiaquine dose (mg/kg) a

    

<1 yb

28.9 [25.3-33.8 , 20.3-45]

32.6 [28.7-36.5 , 22.8-62.9]

33.9 [30.3-37 , 19-50]

22.9 [21.4-25 , 19-30]

1 to <5 y

33.8 [28.9-40.5 , 14.5-81]

38.3 [32.2-45.9 , 14.8-91.8]

33.3 [30-37.5 , 19.7-60]

25.0 [22.7-25 , 21.1-25]

5 to <12 y

33.8 [27-40.5 , 18.9-54]

35.3 [29.5-42 , 16.7-65.6]

34.1 [31.6-39.8 , 27.3-60]

24.1 [23.7-25 , 22.6-26]

≥12 y

29.5 [25.7-35.2 , 15.6-57.9]

33.4 [28.7-39.9 , 18-73.4]

38.9 [33.3-44.2 , 28.1-55.8]

24.0 [23.1-25 , 15.6-26]

Overall

32.4 [27-39 , 14.5-81]

35.3 [30.6-43.7 , 14.8-91.8]

33.7 [30.6-38.1 , 19-60]

25.0 [22.7-25 , 15.6-30]

  1. aThe overall median mg/kg amodiaquine dose administered was 32.1 mg/kg [IQR = 25.9-38.2, range = 14.5-91.8].
  2. The overall median mg/kg artesunate dose administered was 12.5 mg/kg [IQR = 10.7-13.6, range = 4.8-30].
  3. bIn children <1 year, the overall median mg/kg amodiaquine dose administered was 28.9 mg/kg [IQR = 25-35.1, range = 18.9-62.7].