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Table 1 EGDT protocol and outcome of selected trials

From: Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials

Study EGDT group Control group Survival benefit
Standard EGDT versus usual care
ARISE 2014 [13] ScvO2 ≥ 70% Usual care No: 28d/90d/ICU/in-hospital mortality
CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h
Jing 2010 [8] ScvO2 ≥ 70% CVP ≥ 8-12 mm Hg Yes: 28d/ICU mortality
CVP ≥ 8-12 mm Hg SBP > 100 mm Hg
SBP >100 mm Hg MAP ≥ 65 mm Hg
MAP ≥ 65 mm Hg UO ≥ 0.5 ml/kg/h
UO ≥ 0.5 ml/kg/h
ProCESS 2014 [14] ScvO2 ≥ 70% Usual care No: 60d/in-hospital mortality
CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h
Rivers 2001 [4] ScvO2 ≥ 70% CVP ≥ 8-12 mm Hg Yes: 28d/60d/in-hospital mortality
CVP ≥ 8-12 mm Hg MAP ≥ 65 mm Hg
MAP ≥ 65 mm Hg UO ≥ 0.5 ml/kg/h
UO ≥ 0.5 ml/kg/h
Wang 2006 [25] ScvO2 ≥ 70% Usual care No: 7d/14d mortality
CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h
Modified EGDT versus usual care
Andrews 2014 [21] JVP > 3 cm; Usual care No: 28d/in-hospital mortality
MAP > 65 mm Hg;
Hb > 7 g/dl
Lin 2006 [23] CVP ≥ 8-12 mm Hg; Usual care Yes: ICU/in-hospital mortality
MAP ≥ 65 mm Hg;
UO ≥ 0.5 ml/kg/h
ProCESS 2014 [14] SBP ≥ 100 mm Hg Usual care No: 60d/in-hospital mortality
Hb > 7.5 g/dl
Standard EGDT versus lactate clearance
Jones 2010 [22] ScvO2 ≥ 70% Lactate clearance ≥ 10% No: in-hospital mortality
CVP ≥ 8-12 mm Hg CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h UO ≥ 0.5 ml/kg/h
Wang 2014 [20] ScvO2 ≥ 70% Lactate < 2 mmol/L No: 7d/28d mortality
CVP ≥ 8-12 mm Hg CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h UO ≥ 0.5 ml/kg/h
Yu 2013 [24] ScvO2 ≥ 70% Lactate clearance ≥ 10% No: 28d mortality
CVP ≥ 8-12 mm Hg CVP ≥ 8-12 mm Hg
MAP ≥ 65 mm Hg MAP ≥ 65 mm Hg
UO ≥ 0.5 ml/kg/h UO ≥ 0.5 ml/kg/h
  1. Abbreviations:EGDT early goal-directed therapy, SBP systolic blood pressure, JVP jugular venous pressure, MAP mean artery pressure, Hb hemoglobin, UO urine output.