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Table 3 Pooled analysis of secondary outcomes

From: Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials

Outcome Comparison Number of studies MD or RR (95% CI) P I 2
Length of ICU stay (d) EGDT versus control group 6 -0.20 (-1.31 to 0.92) 0.73 75%
Length of in-hospital stay (d) EGDT versus control group 4 0.42 (-1.02 to 1.86) 0.57 12%
Mechanical ventilation rate EGDT versus control group 5 0.96 (0.85 to 1.09) 0.53 43%
Mechanical ventilation days (d) EGDT versus control group 4 -0.91 (-2.34 to 0.52) 0.21 95%
Vasopressor support rate EGDT versus control group 6 1.03 (0.93 to 1.15) 0.58 69%
Inotropic agents support EGDT versus control group 5 2.23 (1.06 to 4.67) 0.03 84%
EGDT versus usual care group 4 2.37 (1.02 to 5.51) 0.05  
EGDT versus early lactate clearance 1 1.60 (0.54 to 4.78) 0.40 88%-
Fluid administration in first 6 h (L) EGDT versus control group 7 0.88 (-0.17 to 1.93) 0.10 99%
EGDT versus usual care group 5 1.24 (0 to 2.48) 0.05 99%
EGDT versus early lactate clearance 2 0.02 (-0.46 to 0.49) 0.27 17%
Red cell transfusion rate in first 6 h EGDT versus control group 5 1.76 (1.11 to 2.78) 0.04 76%
EGDT versus usual care group 3 2.26 (1.54 to 3.31) <0.01 71%
EGDT versus early lactate clearance 2 0.72 (0.27 to 1.94) 0.52 37%
  1. Abbreviations:EGDT early goal-directed therapy, MD mean difference, RR relative risk.