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Table 2 TB incidence rates during ART stratified according to time-updated anaemia severity and CD4 cell count

From: The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study

 

Overall TB incidence

TB incidence in first 4 months of ART

TB incidence after 4 months of ART

 

Total number

PY at risk

Rate per 100

Total number

PY at risk*

Rate per 100

Total number

PY at risk*

Rate per 100

PYs (95%CI)

PYs (95%CI)

PYs (95%CI)

Updated WHO Anaemia severity

         

None

183

4,199.9

4.4 (3.8-5.1)

17

101.4

16.8 (10.6-28.2)

166

4,098.5

4.1 (3.5-4.7)

Mild

113

1,131.0

10.0 (8.3-12.1)

23

85.1

27.0 (18.1-42.1)

90

1,045.9

8.6 (7.0-10.7)

Moderate

154

578.6

26.6 (22.5-31.7)

39

111.2

35.1 (25.8-48.9)

115

467.4

24.6 (20.2-30.1)

Severe

26

29.6

87.8 (57.0-138.2)

8

11.2

71.7 (36.0-159.2)

18

18.5

97.5 (57.1-171.8)

Updated CD4 cell count (cells/uL)

         

≥500

67

1,763.1

3.8 (3.0-4.9)

0

1.8

0

67

1,761.1

3.8 (3.0-4.9)

200-499

200

3,055.9

6.5 (5.7-7.6)

5

47.8

10.5 (4.4-31.0)

195

3,008.1

6.5 (5.6-7.5)

100-199

104

827.2

12.6 (10.4-15.4)

29

132.1

21.9 (15.4-32.4)

75

695.1

10.8 (8.6-13.7)

<100

105

292.9

35.8 (29.6-43.8)

53

127.0

41.7 (32.0-55.3)

52

165.9

31.3 (23.9-41.6)

Total

476

5,939.1

8.0 (7.3-8.8)

87

308.8

28.2 (22.9-35.0)

389

5,630.0

6.9 (6.2-7.7)

  1. Abbreviations:ART antiretroviral therapy, CI confidence interval, TB tuberculosis; WHO World Health Organization.
  2. *Person-time accrued during treatment of prevalent or incident TB (520.1 PYs) was excluded when calculating TB incidence rates.