From: The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
Variable (no. of patients) | Proportion (95% CI) with any DDI | Univariate multilevel odds ratio (95% CI) | Adjusted multilevel odds ratio (95% CI) |
---|---|---|---|
Age groups (years) | |||
20–29 (n = 9,976) | 4.5 (4.0–5.0) | Reference | Reference |
30–39 (n = 12,294) | 9.2 (8.6–9.8) | 2.18 (1.5–2.44) | 1.88 (1.68–2.11) |
40–49 (n = 18,805) | 15.8 (14.9–16.6) | 4.05 (3.65–4.49) | 3.05 (2.75–3.39) |
50–59 (n = 23,565) | 25.1 (24.0–26.2) | 7.28 (6.59–8.04) | 4.67 (4.21–5.17) |
60–69 (n = 30,756) | 33.8 (32.8–34.8) | 11.2 (10.1–12.3) | 6.05 (5.47–6.69) |
70–79 (n = 27,240) | 42.5 (41.4–43.6) | 16.2 (14.7–17.9) | 6.98 (6.31–7.72) |
80+ (n = 17,977) | 46.0 (44.8–47.1) | 18.8 (17.0–20.7) | 7.34 (6.62–8.14) |
Sex | |||
Male (n = 58,466) | 30.7 (30.0–31.5) | Reference | Reference |
Female (n = 82,147) | 27.7 (27.0–28.4) | 0.87 (0.85–0.88) | 0.85 (0.83–0.88) |
Place of residence | |||
Living in own home (n = 13,615) | 28.7 (28.1–29.4) | Reference | Reference |
Living in care home (n = 2,998) | 38.0 (36.3–39.7) | 1.51 (1.40–1.63) | 0.51 (0.47–0.56) |
No. of drugs dispensed in last 84 days | |||
2–4 (n = 71,427) | 10.9 (10.4–11.4) | Reference | Reference |
5–9 (n = 50,972) | 40.0 (39.0–40.9) | 5.49 (5.33–5.65) | 4.39 (4.26–4.53) |
10–14 (n = 14,662) | 65.9 (64.9–67.0) | 16.1 (15.5–16.8) | 12.0 (11.5–12.5) |
15+ (n = 3,552) | 80.8 (79.4–82.2) | 35.3 (32.3–38.5) | 26.8 (24.5–29.3) |