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Table 2 Baseline characteristics of the patients

From: The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis

Variable n All (n = 647) Survived (n = 540) Died (n = 107) P
Age (years) 646 30 (22 to 42) 30 (22 to 40) 34 (26 to 45) 0.003
Sex (% male) 646 483 (75%) 409 (76%) 74 (69%) 0.14
Temperature (°C) 647 38.3 (37.5 to 39.0) 38.3 (37.5 to 39.0) 38 (37 to 39.0) 0.04
Mean arterial pressure (mmHg) 646 76.7 (70 to 86.7) 76.7 (70 to 86.7) 79.2 (66.9 to 90.0) 0.31
Heart rate (beats/minute) 641 106 (96 to 120) 105 (95 to 120) 113 (100 to 123) 0.01
Respiratory rate (breaths/minute) 642 28 (24 to 32) 28 (24 to 32) 32 (28 to 40) <0.001
Glasgow coma scale score 647 10 (8 to 15) 10 (8 to 15) 9 (7 to 13) <0.001
Haematocrit (%) 646 30 (24 to 36) 30 (24 to 36) 30 (23 to 36) 0.95
Reticulocyte count (%) 514 0.8 (0.4 to 1.2) 0.8 (0.4 to 1.2) 0.5 (0.3 to 1.1) 0.008
Reticulocyte index 517 0.5 (0.3 to 0.8) 0.5 (0.3 to 0.9) 0.4 (0.2 to 0.7) 0.01
White cell count (× 109/L) 643 8.7 (6.2 to 12) 8.1 (6 to 11.2) 11.8 (9.1 to 16.3) <0.001
Platelet count (× 109/L) 647 48 (30 to 72) 50 (34 to 78) 30 (22 to 52) <0.001
Mean platelet volume (fL) 34 11.4 (10.4 to 12.4) 11.5 (10.4 to 12.4) 11.3 (11.2 to 12.6) 0.82
Parasite count (parasites/mL) 639 90.4 (18.5 to 327.6) 78.6 (16.1 to 326.7) 101.8 (33.3 to 373.3) 0.09
Sequestration (% blocked capillaries) 107 13.3 (3.3 to 31.5) 10 (2.9 to 26.6) 23.2 (10.0 to 44.0) 0.008
PfHRP2 (ng/mL) 109 2,351 (1,198 to 4,805) 2,187 (976 to 4,216) 3,275 (1,479 to 6,406) 0.07
Lactate (mmol/L) 640 3.5 (2.0 to 4.6) 3.2 (2.0 to 4.6) 5.7 (3.4 to 9.0) <0.001
Base deficit (mEq/L) 395 5 (2 to 10) 5 (2 to 8) 11 (7 to 17) <0.001
Anuric on admission 565 51/565 (9%) 35/483 (7.3%) 16/82 (19.5%) <0.001
Shock on admission 647 47/647 (7.3%) 27/540 (5%) 20/107 (18.7%) <0.001
Pulmonary oedema on admission 646 15/646 (2.3%) 8/539 (1.5%) 7/107 (6.5%) 0.002
Bleeding on admission 646 34/646 (5.2%) 26/539 (4.8%) 8/107 (7.5%) 0.26
Sodium (mmol/L) 460 133 (127 to 138) 133 (127 to 138) 135 (130 to 140) 0.02
Potassium (mmol/L) 525 4.0 (3.6 to 4.5) 4.0 (3.5 to 4.5) 4.2 (3.7 to 4.8) 0.02
Creatinine (μmol/L) 644 176 (123 to 282) 176 (123 to 254) 239 (146 to 441) <0.001
Total bilirubin (μmol/L) 544 57.8 (30.6 to 146.2) 51 (27.2 to 119.0) 146.2 (52.7 to 248.2) <0.001
Direct bilirubin (μmol/L) 420 27.2 (13.6 to 71.4) 23.8 (13.6 to 64.6) 62.9 (20.4 to 127.6) <0.001
Indirect bilirubin (μmol/L) 420 34.8 (17.0 to 74.8) 34 (14.4 to 64.6) 73.1 (40.4 to 102.3) <0.001
Angiopoietin-2 (ng/mL) 152 18.2 (10.2 to 29.8) 13.5 (9.4 to 25.1) 25 (14.8 to 41.0) <0.001
  1. The values represent the median (interquartile range) and absolute number (%). PfHRP2: Plasmodium falciparum histidine rich protein 2.