|
Age (years)
|
646
|
30 (22 to 42)
|
30 (22 to 40)
|
34 (26 to 45)
|
0.003
|
|
Sex (% male)
|
646
|
483 (75%)
|
409 (76%)
|
74 (69%)
|
0.14
|
|
Temperature (°C)
|
647
|
38.3 (37.5 to 39.0)
|
38.3 (37.5 to 39.0)
|
38 (37 to 39.0)
|
0.04
|
|
Mean arterial pressure (mmHg)
|
646
|
76.7 (70 to 86.7)
|
76.7 (70 to 86.7)
|
79.2 (66.9 to 90.0)
|
0.31
|
|
Heart rate (beats/minute)
|
641
|
106 (96 to 120)
|
105 (95 to 120)
|
113 (100 to 123)
|
0.01
|
|
Respiratory rate (breaths/minute)
|
642
|
28 (24 to 32)
|
28 (24 to 32)
|
32 (28 to 40)
|
<0.001
|
|
Glasgow coma scale score
|
647
|
10 (8 to 15)
|
10 (8 to 15)
|
9 (7 to 13)
|
<0.001
|
|
Haematocrit (%)
|
646
|
30 (24 to 36)
|
30 (24 to 36)
|
30 (23 to 36)
|
0.95
|
|
Reticulocyte count (%)
|
514
|
0.8 (0.4 to 1.2)
|
0.8 (0.4 to 1.2)
|
0.5 (0.3 to 1.1)
|
0.008
|
|
Reticulocyte index
|
517
|
0.5 (0.3 to 0.8)
|
0.5 (0.3 to 0.9)
|
0.4 (0.2 to 0.7)
|
0.01
|
|
White cell count (× 109/L)
|
643
|
8.7 (6.2 to 12)
|
8.1 (6 to 11.2)
|
11.8 (9.1 to 16.3)
|
<0.001
|
|
Platelet count (× 109/L)
|
647
|
48 (30 to 72)
|
50 (34 to 78)
|
30 (22 to 52)
|
<0.001
|
|
Mean platelet volume (fL)
|
34
|
11.4 (10.4 to 12.4)
|
11.5 (10.4 to 12.4)
|
11.3 (11.2 to 12.6)
|
0.82
|
|
Parasite count (parasites/mL)
|
639
|
90.4 (18.5 to 327.6)
|
78.6 (16.1 to 326.7)
|
101.8 (33.3 to 373.3)
|
0.09
|
|
Sequestration (% blocked capillaries)
|
107
|
13.3 (3.3 to 31.5)
|
10 (2.9 to 26.6)
|
23.2 (10.0 to 44.0)
|
0.008
|
|
PfHRP2 (ng/mL)
|
109
|
2,351 (1,198 to 4,805)
|
2,187 (976 to 4,216)
|
3,275 (1,479 to 6,406)
|
0.07
|
|
Lactate (mmol/L)
|
640
|
3.5 (2.0 to 4.6)
|
3.2 (2.0 to 4.6)
|
5.7 (3.4 to 9.0)
|
<0.001
|
|
Base deficit (mEq/L)
|
395
|
5 (2 to 10)
|
5 (2 to 8)
|
11 (7 to 17)
|
<0.001
|
|
Anuric on admission
|
565
|
51/565 (9%)
|
35/483 (7.3%)
|
16/82 (19.5%)
|
<0.001
|
|
Shock on admission
|
647
|
47/647 (7.3%)
|
27/540 (5%)
|
20/107 (18.7%)
|
<0.001
|
|
Pulmonary oedema on admission
|
646
|
15/646 (2.3%)
|
8/539 (1.5%)
|
7/107 (6.5%)
|
0.002
|
|
Bleeding on admission
|
646
|
34/646 (5.2%)
|
26/539 (4.8%)
|
8/107 (7.5%)
|
0.26
|
|
Sodium (mmol/L)
|
460
|
133 (127 to 138)
|
133 (127 to 138)
|
135 (130 to 140)
|
0.02
|
|
Potassium (mmol/L)
|
525
|
4.0 (3.6 to 4.5)
|
4.0 (3.5 to 4.5)
|
4.2 (3.7 to 4.8)
|
0.02
|
|
Creatinine (μmol/L)
|
644
|
176 (123 to 282)
|
176 (123 to 254)
|
239 (146 to 441)
|
<0.001
|
|
Total bilirubin (μmol/L)
|
544
|
57.8 (30.6 to 146.2)
|
51 (27.2 to 119.0)
|
146.2 (52.7 to 248.2)
|
<0.001
|
|
Direct bilirubin (μmol/L)
|
420
|
27.2 (13.6 to 71.4)
|
23.8 (13.6 to 64.6)
|
62.9 (20.4 to 127.6)
|
<0.001
|
|
Indirect bilirubin (μmol/L)
|
420
|
34.8 (17.0 to 74.8)
|
34 (14.4 to 64.6)
|
73.1 (40.4 to 102.3)
|
<0.001
|
|
Angiopoietin-2 (ng/mL)
|
152
|
18.2 (10.2 to 29.8)
|
13.5 (9.4 to 25.1)
|
25 (14.8 to 41.0)
|
<0.001
|
