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Table 3 Estimated hazard ratios for treatment effect (active treatment versus placebo) and associated 95% confidence intervals, by frailty index

From: No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over

 

Stroke

Cardiovascular events

Total mortality

Frailty index

HR

95% CI

HR

95% CI

HR

95% CI

0.1

0.75

0.40–1.38

0.62

0.42–0.92

0.89

0.63–1.25

0.2

0.66

0.43–1.01

0.60

0.45–0.78

0.84

0.66–1.07

0.3

0.59

0.36–0.96

0.57

0.42–0.79

0.80

0.61–1.04

0.4

0.52

0.25–1.09

0.55

0.34–0.89

0.76

0.50–1.14

0.5

0.47

0.16–1.33

0.53

0.26–1.06

0.72

0.40–1.29

0.6

0.41

0.10–1.65

0.50

0.20–1.27

0.68

0.32–1.48

  1. All models adjusted by age, sex, and interaction between treatment and frailty index, and stratified by region of recruitment.