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Table 2 Association between TSH, FT4, and risk of AMD

From: Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

Incident AMD versus no AMD AMD N Total N HR (95% CI), model 1 HR (95% CI), model 2 HR (95% CI), model 3
TSH, mIU/L 805 5,572 0.99 (0.91-1.07) 0.99 (0.91-1.07) 0.99 (0.91-1.07)
TSH in normal range a 696 4,756 1.06 (0.91-1.23) 1.09 (0.93-1.27) 1.08 (0.93-1.26)
Normal range TSH a      
Q1 0.40-1.10 148 1,082 1.04 (0.82-1.32) 1.00 (0.79-1.28) 1.00 (0.79-1.28)
Q2 1.11-1.54 167 990 1.32 (1.04-1.66) 1.29 (1.02-1.62) 1.29 (1.02-1.62)
Q3 1.55-1.99 128 962 reference reference reference
Q4 2.00-2.61 117 851 1.09 (0.85-1.40) 1.07 (0.83-1.37) 1.07 (0.83-1.38)
Q5 2.62-3.97 136 871 1.22 (0.96-1.56) 1.22 (0.95-1.55) 1.21 (0.94-1.54)
P interaction    0.648 0.485 0.517
Total 696 4,756    
FT4, pmol/L 791 5,504 1.04 (1.01-1.06) 1.04 (1.01-1.06) 1.04 (1.01-1.06)
FT4 in normal range b 765 5,382 1.04 (1.01-1.07) 1.04 (1.01-1.07) 1.04 (1.01-1.07)
Normal range FT4 b      
Q1 11.0-14.0 149 1,090 1.03 (0.82-1.29) 1.04 (0.82-1.31) 1.04 (0.82-1.31)
Q2 14.0-15.1 152 1,001 1.12 (0.89-1.41) 1.17 (0.92-1.47) 1.16 (0.92-1.47)
Q3 15.1-16.2 144 1,094 reference reference reference
Q4 16.2-17.5 134 1,060 1.01 (0.80-1.28) 1.03 (0.81-1.30) 1.03 (0.81-1.31)
Q5 17.5-24.9 186 1,137 1.34 (1.07-1.66) 1.35 (1.08-1.69) 1.35 (1.09-1.69)
P interaction 765 5,382 0.066 0.088 0.080
Normal range FT4 b in normal range TSH a 673 4,658 1.04 (1.01-1.08) 1.04 (1.01-1.08) 1.04 (1.01-1.07)
  1. aNormal range of TSH defined as 0.4-4.0 mIU/L. bNormal range of FT4 defined as 11–25 pmol/L.
  2. Model 1: Adjusted for sex and age. Model 2: Model 1 + smoking, hypertension, cholesterol, diabetes, BMI. Model 3: Model 2 + thyroid peroxidase antibodies positivity.
  3. Abbreviations: AMD age-related macular degeneration, BMI body mass index, CI confidence interval, FT4 free T4, HR hazard ratio, Q quintile, TSH thyroid-stimulating hormone.