Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

Table 2 Association between TSH, FT4, and risk of AMD

Incident AMD versus no AMD	AMD N	Total N	HR (95% CI), model 1	HR (95% CI), model 2	HR (95% CI), model 3
TSH, mIU/L	805	5,572	0.99 (0.91-1.07)	0.99 (0.91-1.07)	0.99 (0.91-1.07)
TSH in normal range ^a	696	4,756	1.06 (0.91-1.23)	1.09 (0.93-1.27)	1.08 (0.93-1.26)
Normal range TSH ^a
Q1 0.40-1.10	148	1,082	1.04 (0.82-1.32)	1.00 (0.79-1.28)	1.00 (0.79-1.28)
Q2 1.11-1.54	167	990	1.32 (1.04-1.66)	1.29 (1.02-1.62)	1.29 (1.02-1.62)
Q3 1.55-1.99	128	962	reference	reference	reference
Q4 2.00-2.61	117	851	1.09 (0.85-1.40)	1.07 (0.83-1.37)	1.07 (0.83-1.38)
Q5 2.62-3.97	136	871	1.22 (0.96-1.56)	1.22 (0.95-1.55)	1.21 (0.94-1.54)
P interaction			0.648	0.485	0.517
Total	696	4,756
FT4, pmol/L	791	5,504	1.04 (1.01-1.06)	1.04 (1.01-1.06)	1.04 (1.01-1.06)
FT4 in normal range ^b	765	5,382	1.04 (1.01-1.07)	1.04 (1.01-1.07)	1.04 (1.01-1.07)
Normal range FT4 ^b
Q1 11.0-14.0	149	1,090	1.03 (0.82-1.29)	1.04 (0.82-1.31)	1.04 (0.82-1.31)
Q2 14.0-15.1	152	1,001	1.12 (0.89-1.41)	1.17 (0.92-1.47)	1.16 (0.92-1.47)
Q3 15.1-16.2	144	1,094	reference	reference	reference
Q4 16.2-17.5	134	1,060	1.01 (0.80-1.28)	1.03 (0.81-1.30)	1.03 (0.81-1.31)
Q5 17.5-24.9	186	1,137	1.34 (1.07-1.66)	1.35 (1.08-1.69)	1.35 (1.09-1.69)
P interaction	765	5,382	0.066	0.088	0.080
Normal range FT4 ^b in normal range TSH ^a	673	4,658	1.04 (1.01-1.08)	1.04 (1.01-1.08)	1.04 (1.01-1.07)

^aNormal range of TSH defined as 0.4-4.0 mIU/L. ^bNormal range of FT4 defined as 11–25 pmol/L.
Model 1: Adjusted for sex and age. Model 2: Model 1 + smoking, hypertension, cholesterol, diabetes, BMI. Model 3: Model 2 + thyroid peroxidase antibodies positivity.
Abbreviations: AMD age-related macular degeneration, BMI body mass index, CI confidence interval, FT4 free T4, HR hazard ratio, Q quintile, TSH thyroid-stimulating hormone.

ISSN: 1741-7015