|
Incident pigment alterations versus no pigment alterations
|
Cases N
|
Total N
|
HR (95% CI), model 1
|
HR (95% CI), model 2
|
HR (95% CI), model 3
|
|---|
|
TSH, mIU/L
|
729
|
5,401
|
0.98 (0.90-1.06)
|
0.97 (0.90-1.06)
|
0.96 (0.88-1.04)
|
|
Normal range TSHb
|
618
|
4,591
|
1.02 (0.87-1.20)
|
1.05 (0.89-1.23)
|
1.04 (0.88-1.22)
|
|
FT4, pmol/L
|
720
|
5,338
|
1.04 (1.01-1.07)
|
1.04 (1.01-1.07)
|
1.04 (1.01-1.07)
|
|
Normal range FT4c
|
697
|
5,226
|
1.04 (1.01-1.07)
|
1.04 (1.01-1.07)
|
1.04 (1.01-1.07)
|
|
Normal range FT4c in normal range TSHb
|
601
|
4,500
|
1.03 (1.00-1.07)
|
1.03 (0.99-1.06)
|
1.03 (0.99-1.06)
|
- aParticipants with late AMD were excluded from this analysis.
- bNormal range of TSH defined as 0.4-4.0 mIU/L.
- cNormal range of FT4 defined as 11–25 pmol/L.
- Model 1: Adjusted for sex and age. Model 2: Model 1 + smoking, hypertension, cholesterol, diabetes, BMI. Model 3: Model 2 + thyroid peroxidase antibodies positivity.
- Abbreviations: BMI body mass index, CI confidence interval, FT4 free thyroxine, HR hazard ratio, TSH thyroid-stimulating hormone.
