Skip to main content

Table 4 Association between FT4 and TSH with retinal pigment alterations a

From: Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

Incident pigment alterations versus no pigment alterations Cases N Total N HR (95% CI), model 1 HR (95% CI), model 2 HR (95% CI), model 3
TSH, mIU/L 729 5,401 0.98 (0.90-1.06) 0.97 (0.90-1.06) 0.96 (0.88-1.04)
Normal range TSHb 618 4,591 1.02 (0.87-1.20) 1.05 (0.89-1.23) 1.04 (0.88-1.22)
FT4, pmol/L 720 5,338 1.04 (1.01-1.07) 1.04 (1.01-1.07) 1.04 (1.01-1.07)
Normal range FT4c 697 5,226 1.04 (1.01-1.07) 1.04 (1.01-1.07) 1.04 (1.01-1.07)
Normal range FT4c in normal range TSHb 601 4,500 1.03 (1.00-1.07) 1.03 (0.99-1.06) 1.03 (0.99-1.06)
  1. aParticipants with late AMD were excluded from this analysis.
  2. bNormal range of TSH defined as 0.4-4.0 mIU/L.
  3. cNormal range of FT4 defined as 11–25 pmol/L.
  4. Model 1: Adjusted for sex and age. Model 2: Model 1 + smoking, hypertension, cholesterol, diabetes, BMI. Model 3: Model 2 + thyroid peroxidase antibodies positivity.
  5. Abbreviations: BMI body mass index, CI confidence interval, FT4 free thyroxine, HR hazard ratio, TSH thyroid-stimulating hormone.