Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

Dora Romaguera; Heather Ward; Petra A Wark; Anne-Claire Vergnaud; Petra H Peeters; Carla H van Gils; Pietro Ferrari; Veronika Fedirko; Mazda Jenab; Marie-Christine Boutron-Ruault; Laure Dossus; Laureen Dartois; Camilla Plambeck Hansen; Christina Catherine Dahm; Genevieve Buckland; María José Sánchez; Miren Dorronsoro; Carmen Navarro; Aurelio Barricarte; Timothy J Key; Antonia Trichopoulou; Christos Tsironis; Pagona Lagiou; Giovanna Masala; Valeria Pala; Rosario Tumino; Paolo Vineis; Salvatore Panico; H Bas Bueno-de-Mesquita; Peter D Siersema; Bodil Ohlsson; Karin Jirström; Maria Wennberg; Lena M Nilsson; Elisabete Weiderpass; Tilman Kühn; Verena Katzke; Kay-Tee Khaw; Nick J Wareham; Anne Tjønneland; Heiner Boeing; José R Quirós; Marc J Gunter; Elio Riboli; Teresa Norat

doi:10.1186/s12916-015-0332-5

Table 2 Hazard ratios (HR) and 95% confidence intervals (95% CIs) for CRC-related and overall mortality among CRC survivors according to categories of the WCRF/AICR score

From: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

	WCRF/AICR score categories
	Category 1	Category 2	Category 3	Category 4	P trend
Score range (men)/(women)	(0–2)/(0–3)	(2.25–2.75)/ (3.25–3.75)	(3–3.75)/(4–4.75)	(4–6)/(5–7)
All
CRC-related mortality
No. of deaths (%)	206 (29.1)	260 (27.0)	283 (25.3)	123 (24.5)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	0.92 (0.76–1.11)	0.77 (0.64–0.93)	0.72 (0.57–0.91)	0.001
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.87 (0.72–1.06)	0.74 (0.61–0.90)	0.70 (0.56–0.89)	<0.0001
Overall mortality
No. of deaths (%)	255 (36.1)	330 (34.2)	359 (32.1)	169 (33.6)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	0.94 (0.79–1.10)	0.79 (0.67–0.93)	0.79 (0.65–0.97)	0.002
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.89 (0.75–1.06)	0.77 (0.66–0.92)	0.79 (0.65–0.98)	0.004
Men
CRC-related mortality
No. of deaths (%)	94 (31.0)	122 (28.1)	130 (24.5)	62 (27.0)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	1.01 (0.77–1.34)	0.80 (0.60–1.05)	0.79 (0.56–1.12)	0.050
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.92 (0.69–1.22)	0.74 (0.54–0.96)	0.69 (0.48–0.99)	0.009
Overall mortality
No. of deaths (%)	118 (38.9)	162 (37.3)	164 (30.9)	87 (37.8)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	1.00 (0.79–1.28)	0.76 (0.59–0.97)	0.78 (0.58–1.06)	0.014
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.94 (0.73–1.21)	0.72 (0.56–0.93)	0.71 (0.52–0.97)	0.004
Women
CRC-related mortality
No. of deaths (%)	112 (27.7)	138 (26.0)	153 (26.0)	61 (22.3)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	0.86 (0.66–1.11)	0.77 (0.60–0.99)	0.67 (0.48–0.92)	0.008
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.81 (0.62–1.06)	0.75 (0.57–0.97)	0.72 (0.51–1.00)	0.027
Overall mortality
No. of deaths (%)	137 (33.9)	168 (31.7)	195 (33.2)	82 (30.0)
Age- and country-adjusted^a
HR (95% CI)	1.00 (reference)	0.88 (0.70–1.11)	0.83 (0.67–1.05)	0.78 (0.59–1.03)	0.062
Multivariate adjusted^b
HR (95% CI)	1.00 (reference)	0.86 (0.68–1.09)	0.82 (0.65–1.04)	0.88 (0.66–1.18)	0.242

^aCox regression model, with age at CRC diagnosis as entry time and age at death or censoring as exit time, stratified by country; ^bMultivariable adjusted models were further adjusted for year of CRC diagnosis, tumor stage, tumor grade, tumor site, sex, educational level, and smoking status.

Back to article page