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Table 2 Hazard ratios (HR) and 95% confidence intervals (95% CIs) for CRC-related and overall mortality among CRC survivors according to categories of the WCRF/AICR score

From: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

  WCRF/AICR score categories
  Category 1 Category 2 Category 3 Category 4 P trend
Score range (men)/(women) (0–2)/(0–3) (2.25–2.75)/ (3.25–3.75) (3–3.75)/(4–4.75) (4–6)/(5–7)  
All      
CRC-related mortality      
No. of deaths (%) 206 (29.1) 260 (27.0) 283 (25.3) 123 (24.5)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 0.92 (0.76–1.11) 0.77 (0.64–0.93) 0.72 (0.57–0.91) 0.001
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.87 (0.72–1.06) 0.74 (0.61–0.90) 0.70 (0.56–0.89) <0.0001
Overall mortality      
No. of deaths (%) 255 (36.1) 330 (34.2) 359 (32.1) 169 (33.6)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 0.94 (0.79–1.10) 0.79 (0.67–0.93) 0.79 (0.65–0.97) 0.002
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.89 (0.75–1.06) 0.77 (0.66–0.92) 0.79 (0.65–0.98) 0.004
Men      
CRC-related mortality      
No. of deaths (%) 94 (31.0) 122 (28.1) 130 (24.5) 62 (27.0)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 1.01 (0.77–1.34) 0.80 (0.60–1.05) 0.79 (0.56–1.12) 0.050
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.92 (0.69–1.22) 0.74 (0.54–0.96) 0.69 (0.48–0.99) 0.009
Overall mortality      
No. of deaths (%) 118 (38.9) 162 (37.3) 164 (30.9) 87 (37.8)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 1.00 (0.79–1.28) 0.76 (0.59–0.97) 0.78 (0.58–1.06) 0.014
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.94 (0.73–1.21) 0.72 (0.56–0.93) 0.71 (0.52–0.97) 0.004
Women      
CRC-related mortality      
No. of deaths (%) 112 (27.7) 138 (26.0) 153 (26.0) 61 (22.3)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 0.86 (0.66–1.11) 0.77 (0.60–0.99) 0.67 (0.48–0.92) 0.008
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.81 (0.62–1.06) 0.75 (0.57–0.97) 0.72 (0.51–1.00) 0.027
Overall mortality      
No. of deaths (%) 137 (33.9) 168 (31.7) 195 (33.2) 82 (30.0)  
Age- and country-adjusteda      
HR (95% CI) 1.00 (reference) 0.88 (0.70–1.11) 0.83 (0.67–1.05) 0.78 (0.59–1.03) 0.062
Multivariate adjustedb      
HR (95% CI) 1.00 (reference) 0.86 (0.68–1.09) 0.82 (0.65–1.04) 0.88 (0.66–1.18) 0.242
  1. aCox regression model, with age at CRC diagnosis as entry time and age at death or censoring as exit time, stratified by country; bMultivariable adjusted models were further adjusted for year of CRC diagnosis, tumor stage, tumor grade, tumor site, sex, educational level, and smoking status.
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