CRC-related mortality | Overall mortality | |||||||
---|---|---|---|---|---|---|---|---|
No. of deaths (%) | HR b | 95% CI | P for Heter. | No. of deaths (%) | HR b | 95% CI | P for Heter. | |
Age- and country-adjusteda | 872 (26.5) | 0.92 | (0.86–0.98) | 1,113 (33.8) | 0.92 | (0.87–0.97) | ||
Multivariate adjustedb | 872 (26.5) | 0.90 | (0.83–0.97) | 1,113 (33.8) | 0.93 | (0.87–0.99) | ||
Sensitivity analyses c | ||||||||
Excluding deaths within 6 mo of diagnosis | 717 (24.4) | 0.89 | (0.82–0.97) | 858 (29.2) | 0.92 | (0.85–0.99) | ||
Participants with complete CRC stage data | 618 (25.6) | 0.88 | (0.80–0.96) | 783 (32.4) | 0.91 | (0.84–0.98) | ||
Effect modification analyses c | ||||||||
By sex | 0.983 | 0.597 | ||||||
Men | 408 (27.3) | 0.89 | (0.79–1.00) | 531 (35.5) | 0.90 | (0.81–0.99) | ||
Women | 464 (25.8) | 0.91 | (0.82–1.01) | 582 (32.4) | 0.96 | (0.88–1.06) | ||
By mean age at diagnosis | ||||||||
<64.6 years | 425 (26.4) | 0.89 | (0.80–0.99) | 0.985 | 515 (32.0) | 0.91 | (0.82–0.99) | 0.553 |
≥64.6 years | 447 (26.5) | 0.92 | (0.83–1.03) | 598 (35.5) | 0.97 | (0.89–1.07) | ||
By year of diagnosis | ||||||||
1992–2001 | 548 (33.5) | 0.88 | (0.80–0.96) | 0.889 | 691 (42.2) | 0.90 | (0.82–0.98) | 0.415 |
2002–2008 | 324 (19.6) | 0.93 | (0.82–1.06) | 422 (25.5) | 0.96 | (0.86–1.08) | ||
By median ‘lag time’ d | ||||||||
<6.5 years | 550 (33.3) | 0.85 | (0.77–0.94) | 0.251 | 687 (41.6) | 0.88 | (0.81–0.96) | 0.094 |
≥6.5 years | 332 (20.2) | 0.96 | (0.84–1.08) | 426 (26.0) | 0.99 | (0.88–1.10) | ||
By tumor stage | ||||||||
I | 51 (8.5) | 0.86 | (0.62–1.20) | 0.279 | 76 (12.6) | 0.80 | (0.61–1.04) | 0.067 |
II | 78 (12.8) | 0.87 | (0.68–1.12) | 108 (17.7) | 0.85 | (0.69–1.06) | ||
III | 294 (34.1) | 0.87 | (0.75–1.00) | 369 (42.8) | 0.94 | (0.83–1.07) | ||
IV | 195 (57.9) | 0.86 | (0.72–1.04) | 230 (68.2) | 0.85 | (0.72–1.01) | ||
By tumor site | 0.263 | 0.137 | ||||||
Colon | 537 (25.9) | 0.95 | (0.86–1.05) | 693 (33.5) | 0.99 | (0.90–1.07) | ||
Rectum | 355 (29.1) | 0.85 | (0.75–0.97) | 420 (34.4) | 0.86 | (0.77–0.96) | ||
By colon sub-site | 0.490 | 0.168 | ||||||
Proximal | 288 (30.3) | 1.07 | (0.92–1.25) | 310 (32.6) | 1.09 | (0.95–1.24) | ||
Distal | 246 (26.1) | 0.81 | (0.70–0.94) | 301 (31.9) | 0.84 | (0.73–0.96) | ||
By smoking status | 0.892 | 0.773 | ||||||
Never smoker | 365 (26.7) | 0.86 | (0.77–0.97) | 448 (32.7) | 0.94 | (0.84–1.05) | ||
Former smoker | 286 (25.6) | 0.91 | (0.79–1.05) | 372 (33.3) | 0.89 | (0.79–1.01) | ||
Current smoker | 214 (27.6) | 1.00 | (0.86–1.16) | 282 (36.4) | 0.96 | (0.84–1.10) |