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Table 3 Hazard ratios (HR) and 95% confidence intervals (95% CIs) for CRC-related and overall mortality among CRC survivors associated with 1-point increment in the WCRF/AICR score; sensitivity and effect modification analyses

From: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

 

CRC-related mortality

Overall mortality

 

No. of deaths (%)

HR b

95% CI

P for Heter.

No. of deaths (%)

HR b

95% CI

P for Heter.

Age- and country-adjusteda

872 (26.5)

0.92

(0.86–0.98)

 

1,113 (33.8)

0.92

(0.87–0.97)

 

Multivariate adjustedb

872 (26.5)

0.90

(0.83–0.97)

 

1,113 (33.8)

0.93

(0.87–0.99)

 

Sensitivity analyses c

        

Excluding deaths within 6 mo of diagnosis

717 (24.4)

0.89

(0.82–0.97)

 

858 (29.2)

0.92

(0.85–0.99)

 

Participants with complete CRC stage data

618 (25.6)

0.88

(0.80–0.96)

 

783 (32.4)

0.91

(0.84–0.98)

 

Effect modification analyses c

        

By sex

   

0.983

   

0.597

  Men

408 (27.3)

0.89

(0.79–1.00)

 

531 (35.5)

0.90

(0.81–0.99)

 

  Women

464 (25.8)

0.91

(0.82–1.01)

 

582 (32.4)

0.96

(0.88–1.06)

 

By mean age at diagnosis

        

  <64.6 years

425 (26.4)

0.89

(0.80–0.99)

0.985

515 (32.0)

0.91

(0.82–0.99)

0.553

  ≥64.6 years

447 (26.5)

0.92

(0.83–1.03)

 

598 (35.5)

0.97

(0.89–1.07)

 

By year of diagnosis

        

  1992–2001

548 (33.5)

0.88

(0.80–0.96)

0.889

691 (42.2)

0.90

(0.82–0.98)

0.415

  2002–2008

324 (19.6)

0.93

(0.82–1.06)

 

422 (25.5)

0.96

(0.86–1.08)

 

By median ‘lag time’ d

        

  <6.5 years

550 (33.3)

0.85

(0.77–0.94)

0.251

687 (41.6)

0.88

(0.81–0.96)

0.094

  ≥6.5 years

332 (20.2)

0.96

(0.84–1.08)

 

426 (26.0)

0.99

(0.88–1.10)

 

By tumor stage

        

  I

51 (8.5)

0.86

(0.62–1.20)

0.279

76 (12.6)

0.80

(0.61–1.04)

0.067

  II

78 (12.8)

0.87

(0.68–1.12)

 

108 (17.7)

0.85

(0.69–1.06)

 

  III

294 (34.1)

0.87

(0.75–1.00)

 

369 (42.8)

0.94

(0.83–1.07)

 

  IV

195 (57.9)

0.86

(0.72–1.04)

 

230 (68.2)

0.85

(0.72–1.01)

 

By tumor site

   

0.263

   

0.137

  Colon

537 (25.9)

0.95

(0.86–1.05)

 

693 (33.5)

0.99

(0.90–1.07)

 

  Rectum

355 (29.1)

0.85

(0.75–0.97)

 

420 (34.4)

0.86

(0.77–0.96)

 

By colon sub-site

   

0.490

   

0.168

  Proximal

288 (30.3)

1.07

(0.92–1.25)

 

310 (32.6)

1.09

(0.95–1.24)

 

  Distal

246 (26.1)

0.81

(0.70–0.94)

 

301 (31.9)

0.84

(0.73–0.96)

 

By smoking status

   

0.892

   

0.773

  Never smoker

365 (26.7)

0.86

(0.77–0.97)

 

448 (32.7)

0.94

(0.84–1.05)

 

  Former smoker

286 (25.6)

0.91

(0.79–1.05)

 

372 (33.3)

0.89

(0.79–1.01)

 

  Current smoker

214 (27.6)

1.00

(0.86–1.16)

 

282 (36.4)

0.96

(0.84–1.10)

 
  1. aCox regression model, with age at CRC diagnosis as entry time and age at death or censoring as exit time, stratified by country; bMultivariable adjusted models were further adjusted for year of CRC diagnosis, tumor stage, tumor grade, tumor site, sex, educational level, and smoking status; cSensitivity and stratified analyses were based on multivariable adjusted model; d‘Lag-time’ means years between recruitment and CRC diagnosis.