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Table 3 Hazard ratios (HR) and 95% confidence intervals (95% CIs) for CRC-related and overall mortality among CRC survivors associated with 1-point increment in the WCRF/AICR score; sensitivity and effect modification analyses

From: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

  CRC-related mortality Overall mortality
  No. of deaths (%) HR b 95% CI P for Heter. No. of deaths (%) HR b 95% CI P for Heter.
Age- and country-adjusteda 872 (26.5) 0.92 (0.86–0.98)   1,113 (33.8) 0.92 (0.87–0.97)  
Multivariate adjustedb 872 (26.5) 0.90 (0.83–0.97)   1,113 (33.8) 0.93 (0.87–0.99)  
Sensitivity analyses c         
Excluding deaths within 6 mo of diagnosis 717 (24.4) 0.89 (0.82–0.97)   858 (29.2) 0.92 (0.85–0.99)  
Participants with complete CRC stage data 618 (25.6) 0.88 (0.80–0.96)   783 (32.4) 0.91 (0.84–0.98)  
Effect modification analyses c         
By sex     0.983     0.597
  Men 408 (27.3) 0.89 (0.79–1.00)   531 (35.5) 0.90 (0.81–0.99)  
  Women 464 (25.8) 0.91 (0.82–1.01)   582 (32.4) 0.96 (0.88–1.06)  
By mean age at diagnosis         
  <64.6 years 425 (26.4) 0.89 (0.80–0.99) 0.985 515 (32.0) 0.91 (0.82–0.99) 0.553
  ≥64.6 years 447 (26.5) 0.92 (0.83–1.03)   598 (35.5) 0.97 (0.89–1.07)  
By year of diagnosis         
  1992–2001 548 (33.5) 0.88 (0.80–0.96) 0.889 691 (42.2) 0.90 (0.82–0.98) 0.415
  2002–2008 324 (19.6) 0.93 (0.82–1.06)   422 (25.5) 0.96 (0.86–1.08)  
By median ‘lag time’ d         
  <6.5 years 550 (33.3) 0.85 (0.77–0.94) 0.251 687 (41.6) 0.88 (0.81–0.96) 0.094
  ≥6.5 years 332 (20.2) 0.96 (0.84–1.08)   426 (26.0) 0.99 (0.88–1.10)  
By tumor stage         
  I 51 (8.5) 0.86 (0.62–1.20) 0.279 76 (12.6) 0.80 (0.61–1.04) 0.067
  II 78 (12.8) 0.87 (0.68–1.12)   108 (17.7) 0.85 (0.69–1.06)  
  III 294 (34.1) 0.87 (0.75–1.00)   369 (42.8) 0.94 (0.83–1.07)  
  IV 195 (57.9) 0.86 (0.72–1.04)   230 (68.2) 0.85 (0.72–1.01)  
By tumor site     0.263     0.137
  Colon 537 (25.9) 0.95 (0.86–1.05)   693 (33.5) 0.99 (0.90–1.07)  
  Rectum 355 (29.1) 0.85 (0.75–0.97)   420 (34.4) 0.86 (0.77–0.96)  
By colon sub-site     0.490     0.168
  Proximal 288 (30.3) 1.07 (0.92–1.25)   310 (32.6) 1.09 (0.95–1.24)  
  Distal 246 (26.1) 0.81 (0.70–0.94)   301 (31.9) 0.84 (0.73–0.96)  
By smoking status     0.892     0.773
  Never smoker 365 (26.7) 0.86 (0.77–0.97)   448 (32.7) 0.94 (0.84–1.05)  
  Former smoker 286 (25.6) 0.91 (0.79–1.05)   372 (33.3) 0.89 (0.79–1.01)  
  Current smoker 214 (27.6) 1.00 (0.86–1.16)   282 (36.4) 0.96 (0.84–1.10)  
  1. aCox regression model, with age at CRC diagnosis as entry time and age at death or censoring as exit time, stratified by country; bMultivariable adjusted models were further adjusted for year of CRC diagnosis, tumor stage, tumor grade, tumor site, sex, educational level, and smoking status; cSensitivity and stratified analyses were based on multivariable adjusted model; d‘Lag-time’ means years between recruitment and CRC diagnosis.