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Table 3 Initial antibiotic therapy by randomization group

From: Procalcitonin and pyuria-based algorithm reduces antibiotic use in urinary tract infections: a randomized controlled trial

  Control group PCT/Pyuria group
All patients (intention-to-treat) (n = 64) (n = 61)
First-line antibiotic therapy   
 Ciprofloxacin 25 (39%) 20 (33%)
 Ceftriaxon 18 (28%) 18 (30%)
 TMP-SMZ 9 (14%) 15 (25%)
 Fosfomycin 6 (9%) 3 (5%)
 Amoxicillin-Clavulanate 5 (8%) 1 (2%)
 Other 1 (2%) 3 (5%)
 NSAIDS 0 1 (2%)
Second-line antibiotic therapy   
 Ciprofloxacin 10 (16%) 15 (25%)
 Ceftriaxon 4 (6%) 4 (7%)
 TMP-SMZ 4 (6%) 3 (5%)
 Amoxicillin-Clavulanate 4 (6%) 3 (5%)
 Other 3 (5%) 5 (8%)
Per-protocol population (n = 52) (n = 44)
First-line antibiotic therapy   
 Ciprofloxacin 20 (38%), efficacious in 90% 15 (34%), efficacious in 87%
 Ceftriaxon 17 (33%), efficacious in 76% 14 (32%), efficacious in 64%
 TMP-SMZ 6 (12%), efficacious in 67% 9 (20%), efficacious in 44%
 Fosfomycin 5 (10%), efficacious in 100% 2 (5%), efficacious in 100%
 Amoxicillin-Clavulanate 3 (6%), efficacious in 67% 1 (2%), efficacious in 100%
 Other 1 (2%) 2 (4%)
 NSAIDS 0 1 (2%)
Second-line antibiotic therapy   
 Ciprofloxacin 10 (19%), efficacious in 100% 11 (25%), efficacious in 82%
 Ceftriaxon 3 (6%), efficacious in 67% 4 (9%), efficacious in 100%
 TMP-SMZ 3 (6%), efficacious in 100% 3 (7%), efficacious in 100%
 Amoxicillin-Clavulanate 4 (8%), efficacious in 100% 2 (5%), efficacious in 100%
 Other 5 (10%) 3 (7%)
  1. TMP-SMX, Trimethoprim-sulfamethoxazole; NSAIDs, Non-steroidal anti-inflammatory drugs.