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Table 4 Antibiotic exposure by randomization group with subgroup analysis

From: Procalcitonin and pyuria-based algorithm reduces antibiotic use in urinary tract infections: a randomized controlled trial

  Control group PCT/Pyuria group P value a
Median (IQR), days Median (IQR), days
All patients (intention-to-treat) (n = 64) (n = 61)  
 Duration of initial antibiotic therapy 10.0 (7.0–11.0) 6.0 (4.0–8.0) <0.001
 Antibiotic exposure within 90 days 10.0 (7.0–16.0) 7.0 (5.0–14.0) 0.011
Per-protocol population (n = 52) (n = 44)  
 Duration of initial antibiotic therapy 10.0 (7.0–11.0) 6.0 (4.0–7.0) <0.001
 Antibiotic exposure within 90 days 10.0 (7.5–16.0) 7.0 (5.0–14.5) 0.025
Female patients (n = 52) (n = 43)  
 Duration of initial antibiotic therapy 9.0 (7.0–10.5) 5.0 (4.0–7.0) <0.001
 Antibiotic exposure within 90 days 10.0 (7.0–14.0) 7.0 (4.0–13.0) 0.022
Male patients (n = 12) (n = 18)  
 Duration of initial antibiotic therapy 11.0 (10.5–12.0) 6.5 (5.0–9.0) 0.003
 Antibiotic exposure within 90 days 16.0 (11.0–21.0) 9.0 (6.0–19.0) 0.062
Inpatients (n = 45) (n = 45)  
 Duration of initial antibiotic therapy 10.0 (8.0–11.0) 7.0 (5.0–9.0) <0.001
 Antibiotic exposure within 90 days 11.0 (10.0–18.5) 8.5 (6.5–16.5) 0.023
Uncomplicated simple UTI (n = 6) (n = 2)  
 Duration of initial antibiotic therapy 1.0 (1.0–1.0) 0.5 (0.0–1.0) 0.127
 Antibiotic exposure within 90 days 1.0 (1.0–1.0) 4.0 (1.0–7.0) 0.513
Complicated simple UTI (n = 12) (n = 16)  
 Duration of initial antibiotic therapy 7.0 (7.0–9.0) 4.0 (2.5–5.5) 0.005
 Antibiotic exposure within 90 days 10.0 (8.0–12.0) 5.5 (3.0–14.0) 0.083
Uncomplicated febrile UTI/pyelonephritis (n = 8) (n = 9)  
 Duration of initial antibiotic therapy 7.0 (7.0–7.5) 4.0 (4.0–6.0) 0.009
 Antibiotic exposure within 90 days 7.0 (7.0–10.5) 6.5 (4.0–11.0) 0.238
Complicated febrile UTI/pyelonephritis (n = 34) (n = 33)  
 Duration of initial antibiotic therapy 10.5 (10.0–11.0) 7.0 (6.0–9.0) <0.001
 Antibiotic exposure within 90 days 11.0 (10.0–18.0) 7.5 (6.5–13.5) 0.002
  1. aMann–Whitney U-test.
  2. IQR, Interquartile range.