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Table 1 Comparison of the plasma phospholipid fatty acid changes for treatments that exclusively increase ALA (Jones et al. [8]) vs. those that decrease LA and increase ALA (Hsieh et al. [9])

From: Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)

  Intake (% wt)   Plasma phospholipid DHA (% wt)
Jones et al. [8], BMC Medicine 2015  
n = 20 per group   LA ALA Basal 28 d Diff (%)  
Control S-RUTF 14.9 1.3 2.51 2.23 −11% n.s.
  F-RUTF 14.4 6.2 2.63 2.08 −21% n.s.
Hsieh et al. [9], JPGN 2015  
Control, n = 38; HO-RUTF, n = 43  
Control C-RUTF 21.3 0.4 3.24 2.43 −25% P = 0.04
  HO-RUTF 13.1 13.1 2.84 2.96 4% n.s.
  1. Jones et al. [8]: From entry DHA drops non-significantly from baseline with a 4.7-fold increase in ALA from flax with no change in LA for both standard (S) and flax oil supplemented (F) RUTF. Hsieh et al. [9]: DHA drops dramatically in control (C); the drop in LA in high oleic (HO) prevents the decrease. Units are percent by weight of fatty acids.